(90 nodes) Viral process network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ATG16L1	Autophagy related 16 like 1. (597 aa)
	VPS4B	Vacuolar protein sorting 4 homolog B; Belongs to the AAA ATPase family. (448 aa)
	CCNT2	Cyclin T2; Belongs to the cyclin family. (750 aa)
	ITGAV	Integrin_alpha2 domain-containing protein. (597 aa)
	EIF3G	Eukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. (270 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1410 aa)
	H2ZUM6_LATCH	Reverse transcriptase domain-containing protein. (220 aa)
	USF1	Upstream transcription factor 1. (293 aa)
	H2ZWA9_LATCH	Uncharacterized protein. (145 aa)
	EIF3D	Eukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7- methylguanosine cap of a subset of mRNAs. (542 aa)
	H2ZXS4_LATCH	Uncharacterized protein. (226 aa)
	IST1	IST1 factor associated with ESCRT-III. (260 aa)
	H2ZZI7_LATCH	Uncharacterized protein. (556 aa)
	VAMP8	Vesicle associated membrane protein 8. (104 aa)
	H3A160_LATCH	Uncharacterized protein. (290 aa)
	UVRAG	UV radiation resistance associated. (407 aa)
	SMPD1	Sphingomyelin phosphodiesterase 1. (396 aa)
	SIVA1	SIVA1 apoptosis inducing factor. (168 aa)
	VPS18	VPS18 core subunit of CORVET and HOPS complexes. (874 aa)
	VTA1	Vta1 domain-containing protein. (43 aa)
	H3A5G3_LATCH	Uncharacterized protein. (747 aa)
	TBC1D20	TBC1 domain family member 20. (396 aa)
	LOC102349073	Zgc:63863. (409 aa)
	H3A6Q2_LATCH	Reverse transcriptase domain-containing protein. (335 aa)
	LOC102365642	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (213 aa)
	H3A7L3_LATCH	Uncharacterized protein. (645 aa)
	H3A7S9_LATCH	Uncharacterized protein. (1292 aa)
	CHMP5	Charged multivesicular body protein 5. (220 aa)
	LOC102348211	ATG16 domain-containing protein. (243 aa)
	LOC102364659	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (319 aa)
	TRIM62	B30.2/SPRY domain-containing protein. (312 aa)
	H3A9B7_LATCH	Uncharacterized protein. (521 aa)
	JPT2	Uncharacterized protein. (195 aa)
	AGTR1	Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	PHB	Prohibitin. (272 aa)
	H3ACN0_LATCH	Uncharacterized protein. (392 aa)
	LOC102362452	Uncharacterized protein. (176 aa)
	LOC102356960	Charged multivesicular body protein 3. (220 aa)
	H3AFZ1_LATCH	Peptidase S72 domain-containing protein. (633 aa)
	CREB3	cAMP responsive element binding protein 3. (452 aa)
	H3AI21_LATCH	C-type lectin domain-containing protein. (146 aa)
	H3AIL4_LATCH	Uncharacterized protein. (627 aa)
	EIF2D	Eukaryotic translation initiation factor 2D. (596 aa)
	VPS4A	Vacuolar protein sorting 4 homolog A; Belongs to the AAA ATPase family. (437 aa)
	GTF2B	General transcription factor IIB. (316 aa)
	H3AM01_LATCH	Integrin beta; Belongs to the integrin beta chain family. (769 aa)
	SMARCB1	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (384 aa)
	H3ANL8_LATCH	Fibroblast activation protein, alpha; Belongs to the peptidase S9B family. (755 aa)
	TSG101	Tumor susceptibility 101. (392 aa)
	ATG16L2	ATG16 autophagy related 16-like 2 (S. cerevisiae). (340 aa)
	EIF3B	Eukaryotic translation initiation factor 3 subunit B; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome; Belongs to the eIF-3 subunit B family. (684 aa)
	PDCD6IP	Programmed cell death 6 interacting protein. (732 aa)
	TPCN1	Two pore segment channel 1. (708 aa)
	H3AS24_LATCH	Uncharacterized protein. (270 aa)
	H3AT24_LATCH	Uncharacterized protein. (709 aa)
	NECTIN4	Nectin cell adhesion molecule 4. (469 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (163 aa)
	RAB1B	RAB1B, member RAS oncogene family. (203 aa)
	RAB1A	RAB1A, member RAS oncogene family. (229 aa)
	EIF3F	Eukaryotic translation initiation factor 3 subunit F; Belongs to the eIF-3 subunit F family. (227 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (2113 aa)
	USP6NL	USP6 N-terminal like. (765 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
	SSB	Small RNA binding exonuclease protection factor La. (409 aa)
	GAS6	Uncharacterized protein. (681 aa)
	DAG1	Dystroglycan 1. (900 aa)
	NECTIN1	Nectin cell adhesion molecule 1. (498 aa)
	H3B4J8_LATCH	Uncharacterized protein. (114 aa)
	EIF3A	Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (1319 aa)
	LRSAM1	Leucine rich repeat and sterile alpha motif containing 1. (732 aa)
	CLDN1	Claudin 1. (210 aa)
	H3B6R7_LATCH	Ion_trans domain-containing protein. (303 aa)
	H3B6Z0_LATCH	Uncharacterized protein. (675 aa)
	CHMP6	Charged multivesicular body protein 6. (146 aa)
	MVB12A	Multivesicular body subunit 12A. (273 aa)
	MVB12B	Multivesicular body subunit 12B. (291 aa)
	LOC102347960	Two pore segment channel 3. (743 aa)
	H3BD64_LATCH	Xenotropic and polytropic retrovirus receptor 1b. (669 aa)
	DDB1	Damage specific DNA binding protein 1. (1142 aa)
	DHX9	DExH-box helicase 9. (1249 aa)
	AXL	AXL receptor tyrosine kinase. (872 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	H3BG98_LATCH	Uncharacterized protein. (688 aa)
	H3BGI4_LATCH	Si:ch211-288d18.1. (622 aa)
	PC	Pyruvate carboxylase. (722 aa)
	M3XGJ3_LATCH	TNFR-Cys domain-containing protein. (163 aa)
	M3XKF3_LATCH	Uncharacterized protein. (55 aa)
	LOC102352322	Aamy domain-containing protein. (520 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (928 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG16L1	ATG5	ENSLACP00000000194	ENSLACP00000015035	Autophagy related 16 like 1.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.990
ATG16L2	ATG5	ENSLACP00000011690	ENSLACP00000015035	ATG16 autophagy related 16-like 2 (S. cerevisiae).	Autophagy protein 5; Involved in autophagic vesicle formation.	0.995
ATG5	ATG16L1	ENSLACP00000015035	ENSLACP00000000194	Autophagy protein 5; Involved in autophagic vesicle formation.	Autophagy related 16 like 1.	0.990
ATG5	ATG16L2	ENSLACP00000015035	ENSLACP00000011690	Autophagy protein 5; Involved in autophagic vesicle formation.	ATG16 autophagy related 16-like 2 (S. cerevisiae).	0.995
ATG5	H3AS24_LATCH	ENSLACP00000015035	ENSLACP00000012445	Autophagy protein 5; Involved in autophagic vesicle formation.	Uncharacterized protein.	0.549
ATG5	LOC102348211	ENSLACP00000015035	ENSLACP00000005950	Autophagy protein 5; Involved in autophagic vesicle formation.	ATG16 domain-containing protein.	0.972
ATG5	PHB	ENSLACP00000015035	ENSLACP00000006862	Autophagy protein 5; Involved in autophagic vesicle formation.	Prohibitin.	0.556
ATG5	TP53	ENSLACP00000015035	ENSLACP00000015915	Autophagy protein 5; Involved in autophagic vesicle formation.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.434
ATG5	UVRAG	ENSLACP00000015035	ENSLACP00000003796	Autophagy protein 5; Involved in autophagic vesicle formation.	UV radiation resistance associated.	0.549
ATG5	VAMP8	ENSLACP00000015035	ENSLACP00000003273	Autophagy protein 5; Involved in autophagic vesicle formation.	Vesicle associated membrane protein 8.	0.463
AXL	GAS6	ENSLACP00000020423	ENSLACP00000016134	AXL receptor tyrosine kinase.	Uncharacterized protein.	0.704
CAV2	CAV3	ENSLACP00000014086	ENSLACP00000020888	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.976
CAV3	CAV2	ENSLACP00000020888	ENSLACP00000014086	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.976
CAV3	H3ANL8_LATCH	ENSLACP00000020888	ENSLACP00000011239	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Fibroblast activation protein, alpha; Belongs to the peptidase S9B family.	0.715
CCNT2	DDB1	ENSLACP00000000256	ENSLACP00000020033	Cyclin T2; Belongs to the cyclin family.	Damage specific DNA binding protein 1.	0.524
CCNT2	GTF2B	ENSLACP00000000256	ENSLACP00000010617	Cyclin T2; Belongs to the cyclin family.	General transcription factor IIB.	0.736
CHMP5	CHMP6	ENSLACP00000005733	ENSLACP00000017820	Charged multivesicular body protein 5.	Charged multivesicular body protein 6.	0.901
CHMP5	IST1	ENSLACP00000005733	ENSLACP00000002797	Charged multivesicular body protein 5.	IST1 factor associated with ESCRT-III.	0.965
CHMP5	LOC102356960	ENSLACP00000005733	ENSLACP00000008539	Charged multivesicular body protein 5.	Charged multivesicular body protein 3.	0.996
CHMP5	MVB12B	ENSLACP00000005733	ENSLACP00000019252	Charged multivesicular body protein 5.	Multivesicular body subunit 12B.	0.486