(82 nodes) Regulation of macroautophagy network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
	TSC2	TSC complex subunit 2. (1836 aa)
	H2ZSK8_LATCH	TYR_PHOSPHATASE_2 domain-containing protein. (101 aa)
	DCN	Decorin; May affect the rate of fibrils formation. (353 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (145 aa)
	RNF31	Uncharacterized protein. (1087 aa)
	TMEM39A	Transmembrane protein 39A. (318 aa)
	SCFD1	Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (632 aa)
	LOC102357296	FPL domain-containing protein. (365 aa)
	LZTS1	Leucine zipper tumor suppressor 1. (493 aa)
	PAFAH1B3	Platelet activating factor acetylhydrolase 1b catalytic subunit 3. (152 aa)
	NRBP2	Nuclear receptor binding protein 2. (458 aa)
	WAC	WW domain containing adaptor with coiled-coil. (643 aa)
	LOC102354722	Uncharacterized protein. (116 aa)
	H3A1S1_LATCH	RUN domain-containing protein. (1123 aa)
	PIP4K2B	Phosphatidylinositol-5-phosphate 4-kinase type 2 beta. (372 aa)
	CLN3	Battenin. (406 aa)
	STING1	Uncharacterized protein. (380 aa)
	C9orf72	C9orf72-SMCR8 complex subunit. (482 aa)
	POLDIP2	DNA polymerase delta interacting protein 2. (369 aa)
	RAB3GAP1	RAB3 GTPase activating protein catalytic subunit 1. (1006 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (567 aa)
	LOC102365031	ApaG domain-containing protein. (345 aa)
	EPM2A	EPM2A glucan phosphatase, laforin. (228 aa)
	SCOC	Short coiled-coil protein. (82 aa)
	LOC102366142	Uncharacterized protein; Belongs to the synaptobrevin family. (216 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (553 aa)
	HTT	Huntingtin. (3125 aa)
	SPTLC1	Serine palmitoyltransferase long chain base subunit 1. (472 aa)
	FYCO1	FYVE and coiled-coil domain containing 1. (1464 aa)
	SNX4	Sorting nexin 4. (405 aa)
	SIRT1	Sirtuin 1. (729 aa)
	SMG1	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3451 aa)
	SUPT5H	Transcription elongation factor SPT5. (1081 aa)
	TBC1D25	TBC1 domain family member 25. (634 aa)
	LOC102356692	Si:zfos-80g12.1. (503 aa)
	SMCR8	SMCR8-C9orf72 complex subunit. (936 aa)
	CLEC16A	C-type lectin domain containing 16A. (610 aa)
	SNX7	Sorting nexin 7. (426 aa)
	PIK3R4	Phosphoinositide-3-kinase regulatory subunit 4. (1363 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (854 aa)
	UBQLN4	Ubiquilin 4. (636 aa)
	VPS13D	Vacuolar protein sorting 13 homolog D. (4423 aa)
	TMEM39B	Transmembrane protein 39B. (487 aa)
	BAG3	BCL2 associated athanogene 3. (561 aa)
	TSC1	TSC complex subunit 1. (1217 aa)
	SESN3	Sestrin 3. (323 aa)
	LRRK2	Leucine rich repeat kinase 2. (2508 aa)
	RUBCN	Rubicon autophagy regulator. (924 aa)
	PIP4K2A	Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (334 aa)
	BNIP3	BCL2 interacting protein 3. (202 aa)
	RAB3GAP2	RAB3 GTPase activating non-catalytic protein subunit 2. (1290 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	HSPB8	Heat shock protein family B (small) member 8; Belongs to the small heat shock protein (HSP20) family. (201 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
	SEC22B	SEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (215 aa)
	H3B3L3_LATCH	NACHT domain-containing protein. (837 aa)
	SNX30	Sorting nexin family member 30. (513 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (830 aa)
	LRSAM1	Leucine rich repeat and sterile alpha motif containing 1. (732 aa)
	ATP13A2	Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1091 aa)
	WDR24	WD repeat domain 24. (790 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (825 aa)
	H3B8U3_LATCH	Serine/threonine-protein kinase TOR. (1418 aa)
	WIPI1	WD repeat domain, phosphoinositide interacting 1. (450 aa)
	FEZ1	Fasciculation and elongation protein zeta 1. (393 aa)
	MTOR	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
	SESN2	Sestrin 2. (463 aa)
	SESN1	Sestrin 1. (463 aa)
	FEZ2	Fasciculation and elongation protein zeta 2. (391 aa)
	GPSM1	G protein signaling modulator 1. (644 aa)
	RNF41	Ring finger protein 41. (319 aa)
	PINK1	PTEN induced kinase 1. (467 aa)
	TIGAR	TP53 induced glycolysis regulatory phosphatase. (212 aa)
	ATG2A	Autophagy related 2A. (1899 aa)
	PIP4K2C	Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (305 aa)
	ULK1	Unc-51 like autophagy activating kinase 1. (1046 aa)
	LARP1	La ribonucleoprotein domain family member 1. (933 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (1195 aa)
	PAFAH1B2	Platelet activating factor acetylhydrolase 1b catalytic subunit 2. (231 aa)
	ATG14	Autophagy related 14. (499 aa)
	LOC102348796	Uncharacterized protein. (497 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBRA1	ATG12	ENSLACP00000021333	ENSLACP00000001446	Autophagy and beclin 1 regulator 1.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.731
AMBRA1	ATG14	ENSLACP00000021333	ENSLACP00000021664	Autophagy and beclin 1 regulator 1.	Autophagy related 14.	0.969
AMBRA1	ATG5	ENSLACP00000021333	ENSLACP00000015035	Autophagy and beclin 1 regulator 1.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.665
AMBRA1	PIK3C3	ENSLACP00000021333	ENSLACP00000018243	Autophagy and beclin 1 regulator 1.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.882
AMBRA1	PIK3R4	ENSLACP00000021333	ENSLACP00000011766	Autophagy and beclin 1 regulator 1.	Phosphoinositide-3-kinase regulatory subunit 4.	0.886
AMBRA1	PRKAA2	ENSLACP00000021333	ENSLACP00000006413	Autophagy and beclin 1 regulator 1.	Non-specific serine/threonine protein kinase.	0.502
AMBRA1	RUBCN	ENSLACP00000021333	ENSLACP00000013888	Autophagy and beclin 1 regulator 1.	Rubicon autophagy regulator.	0.497
AMBRA1	ULK1	ENSLACP00000021333	ENSLACP00000021180	Autophagy and beclin 1 regulator 1.	Unc-51 like autophagy activating kinase 1.	0.801
AMBRA1	WIPI1	ENSLACP00000021333	ENSLACP00000018467	Autophagy and beclin 1 regulator 1.	WD repeat domain, phosphoinositide interacting 1.	0.454
ATG12	AMBRA1	ENSLACP00000001446	ENSLACP00000021333	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy and beclin 1 regulator 1.	0.731
ATG12	ATG14	ENSLACP00000001446	ENSLACP00000021664	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy related 14.	0.946
ATG12	ATG2A	ENSLACP00000001446	ENSLACP00000020478	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy related 2A.	0.543
ATG12	ATG5	ENSLACP00000001446	ENSLACP00000015035	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	BNIP3	ENSLACP00000001446	ENSLACP00000014880	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	BCL2 interacting protein 3.	0.426
ATG12	H3B8U3_LATCH	ENSLACP00000001446	ENSLACP00000018314	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Serine/threonine-protein kinase TOR.	0.469
ATG12	LOC102354722	ENSLACP00000001446	ENSLACP00000003501	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Uncharacterized protein.	0.426
ATG12	MTOR	ENSLACP00000001446	ENSLACP00000018843	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.469
ATG12	NOD2	ENSLACP00000001446	ENSLACP00000011767	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Nucleotide binding oligomerization domain containing 2.	0.908
ATG12	PIK3C3	ENSLACP00000001446	ENSLACP00000018243	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.982
ATG12	PIK3R4	ENSLACP00000001446	ENSLACP00000011766	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Phosphoinositide-3-kinase regulatory subunit 4.	0.981