STRINGSTRING
UNG UNG LOC102360187 LOC102360187 H2ZTU8_LATCH H2ZTU8_LATCH H2ZX83_LATCH H2ZX83_LATCH LIG4 LIG4 MSH3 MSH3 RAG1 RAG1 RAG2 RAG2 ATM ATM LEF1 LEF1 KIAA1841 KIAA1841 NHEJ1 NHEJ1 EXOSC3 EXOSC3 RNF8 RNF8 H3AFK9_LATCH H3AFK9_LATCH MLH1 MLH1 NBN NBN AICDA AICDA XRCC4 XRCC4 PRKDC PRKDC POLB POLB H3B480_LATCH H3B480_LATCH MSH6 MSH6 DEF6 DEF6 CD40LG CD40LG DCAF1 DCAF1 TCF7 TCF7 ATAD5 ATAD5 EXO1 EXO1 BATF BATF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UNGUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (315 aa)
LOC102360187MutS homolog 2 (E. coli). (447 aa)
H2ZTU8_LATCHUncharacterized protein. (60 aa)
H2ZX83_LATCHMutS homolog 2 (E. coli). (360 aa)
LIG4DNA ligase. (911 aa)
MSH3MutS homolog 3; Component of the post-replicative DNA mismatch repair system (MMR). (798 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1045 aa)
RAG2Recombination activating 2. (522 aa)
ATMATM serine/threonine kinase. (2375 aa)
LEF1Lymphoid enhancer binding factor 1. (397 aa)
KIAA1841KIAA1841. (734 aa)
NHEJ1Uncharacterized protein. (303 aa)
EXOSC3Exosome component 3. (244 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (542 aa)
H3AFK9_LATCHRING-type domain-containing protein. (482 aa)
MLH1MutL homolog 1. (821 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (772 aa)
AICDAActivation-induced cytidine deaminase. (149 aa)
XRCC4X-ray repair cross complementing 4. (331 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4083 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
H3B480_LATCHUncharacterized protein. (567 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
DEF6DEF6 guanine nucleotide exchange factor. (624 aa)
CD40LGCD40 ligand; Belongs to the tumor necrosis factor family. (284 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1510 aa)
TCF7Transcription factor 7. (343 aa)
ATAD5ATPase family AAA domain containing 5. (1828 aa)
EXO1Exonuclease 1. (805 aa)
BATFBasic leucine zipper ATF-like transcription factor. (119 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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