(30 nodes) Protein-hormone receptor activity network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	LGR5	Leucine rich repeat containing G protein-coupled receptor 5. (625 aa)
	LOC102350151	Uncharacterized protein. (383 aa)
	LOC102350837	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	GNRHR1/III	G_PROTEIN_RECEP_F1_2 domain-containing protein. (389 aa)
	ADIPOR2	Adiponectin receptor 2. (372 aa)
	GNRHR2/nmI	Gonadotropin releasing hormone receptor 1; Belongs to the G-protein coupled receptor 1 family. (330 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (689 aa)
	LOC102355121	G_PROTEIN_RECEP_F1_2 domain-containing protein. (310 aa)
	GPR1	G protein-coupled receptor 1. (382 aa)
	INSRR	Tyrosine-protein kinase receptor. (323 aa)
	H3B644_LATCH	Uncharacterized protein. (954 aa)
	LGR6	Leucine rich repeat containing G protein-coupled receptor 6. (893 aa)
	LOC102359601	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (338 aa)
	LOC102356748	Formyl peptide receptor 1. (368 aa)
	LOC102346610	G_PROTEIN_RECEP_F1_2 domain-containing protein. (419 aa)
	GNRHR	Type I gonadotropin-releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (329 aa)
	MCHR1	Melanin concentrating hormone receptor 1. (352 aa)
	LOC102358202	Tyrosine-protein kinase receptor. (838 aa)
	LOC102358168	G_PROTEIN_RECEP_F1_2 domain-containing protein. (352 aa)
	RXFP2	Relaxin family peptide receptor 2. (763 aa)
	IGF1R	Insulin like growth factor 1 receptor. (1170 aa)
	H3AGX2_LATCH	Recep_L_domain domain-containing protein. (179 aa)
	H3AGZ1_LATCH	DDB1 and CUL4 associated factor 8. (618 aa)
	LOC102355680	Melanin-concentrating hormone receptor 1a. (337 aa)
	INSR	Uncharacterized protein. (270 aa)
	LOC102360823	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (348 aa)
	LHCGR	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (593 aa)
	ADIPOR1	Adiponectin receptor 1. (377 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (955 aa)
	GNRHR-2	G_PROTEIN_RECEP_F1_2 domain-containing protein. (338 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOR1	ADIPOR2	ENSLACP00000013484	ENSLACP00000020177	Adiponectin receptor 1.	Adiponectin receptor 2.	0.926
ADIPOR1	LOC102350151	ENSLACP00000013484	ENSLACP00000022900	Adiponectin receptor 1.	Uncharacterized protein.	0.901
ADIPOR2	ADIPOR1	ENSLACP00000020177	ENSLACP00000013484	Adiponectin receptor 2.	Adiponectin receptor 1.	0.926
ADIPOR2	LOC102350151	ENSLACP00000020177	ENSLACP00000022900	Adiponectin receptor 2.	Uncharacterized protein.	0.901
GNRHR	LHCGR	ENSLACP00000002447	ENSLACP00000012918	Type I gonadotropin-releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family.	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.	0.453
GNRHR-2	LHCGR	ENSLACP00000015324	ENSLACP00000012918	G_PROTEIN_RECEP_F1_2 domain-containing protein.	Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.	0.403
H3AGX2_LATCH	IGF1R	ENSLACP00000008893	ENSLACP00000008032	Recep_L_domain domain-containing protein.	Insulin like growth factor 1 receptor.	0.900
H3AGX2_LATCH	INSR	ENSLACP00000008893	ENSLACP00000011313	Recep_L_domain domain-containing protein.	Uncharacterized protein.	0.928
H3AGX2_LATCH	INSRR	ENSLACP00000008893	ENSLACP00000017566	Recep_L_domain domain-containing protein.	Tyrosine-protein kinase receptor.	0.897
H3AGX2_LATCH	LOC102358202	ENSLACP00000008893	ENSLACP00000005349	Recep_L_domain domain-containing protein.	Tyrosine-protein kinase receptor.	0.900
H3B644_LATCH	INSRR	ENSLACP00000017365	ENSLACP00000017566	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.860
IGF1R	H3AGX2_LATCH	ENSLACP00000008032	ENSLACP00000008893	Insulin like growth factor 1 receptor.	Recep_L_domain domain-containing protein.	0.900
INSR	H3AGX2_LATCH	ENSLACP00000011313	ENSLACP00000008893	Uncharacterized protein.	Recep_L_domain domain-containing protein.	0.928
INSR	INSRR	ENSLACP00000011313	ENSLACP00000017566	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.941
INSR	LOC102358202	ENSLACP00000011313	ENSLACP00000005349	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.900
INSRR	H3AGX2_LATCH	ENSLACP00000017566	ENSLACP00000008893	Tyrosine-protein kinase receptor.	Recep_L_domain domain-containing protein.	0.897
INSRR	H3B644_LATCH	ENSLACP00000017566	ENSLACP00000017365	Tyrosine-protein kinase receptor.	Uncharacterized protein.	0.860
INSRR	INSR	ENSLACP00000017566	ENSLACP00000011313	Tyrosine-protein kinase receptor.	Uncharacterized protein.	0.941
LGR4	LGR5	ENSLACP00000013735	ENSLACP00000000237	Leucine rich repeat containing G protein-coupled receptor 4.	Leucine rich repeat containing G protein-coupled receptor 5.	0.734
LGR4	LGR6	ENSLACP00000013735	ENSLACP00000017322	Leucine rich repeat containing G protein-coupled receptor 4.	Leucine rich repeat containing G protein-coupled receptor 6.	0.926