(33 nodes) Peptidase activator activity network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PSME2	Proteasome activator subunit 2. (241 aa)
	CTSC	Cathepsin C; Belongs to the peptidase C1 family. (461 aa)
	CASP8AP2	Caspase 8 associated protein 2. (1555 aa)
	PSME4	Proteasome activator subunit 4. (1848 aa)
	LOC102354291	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (169 aa)
	PSME3	Proteasome activator subunit 3. (257 aa)
	PSME1	Proteasome activator subunit 1. (252 aa)
	PSMD14	Proteasome 26S subunit, non-ATPase 14. (314 aa)
	EBAG9	Estrogen receptor binding site associated antigen 9; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. (213 aa)
	BCL2L13	BCL2 like 13. (455 aa)
	FN1	Fibronectin 1. (2295 aa)
	CTSH	Cathepsin H; Belongs to the peptidase C1 family. (329 aa)
	SFRP2	Secreted frizzled related protein 2. (294 aa)
	WDR48	WD repeat domain 48. (677 aa)
	H3AJI4_LATCH	Uncharacterized protein. (272 aa)
	ADRM1	Adhesion regulating molecule 1. (438 aa)
	PSENEN	Presenilin enhancer, gamma-secretase subunit. (101 aa)
	BAD	Uncharacterized protein. (175 aa)
	LOC102360420	Uncharacterized protein. (264 aa)
	H3ASA2_LATCH	Ig-like domain-containing protein. (290 aa)
	PCOLCE2	Procollagen C-endopeptidase enhancer 2. (471 aa)
	APH1B	Aph-1 homolog B, gamma-secretase subunit. (258 aa)
	NLRC4	NLR family CARD domain containing 4. (1032 aa)
	APAF1	Apoptotic peptidase activating factor 1. (1202 aa)
	H3B0U5_LATCH	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (436 aa)
	RACK1	Receptor for activated C kinase 1. (317 aa)
	FBLN1	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (701 aa)
	TMEM198	Transmembrane protein 198. (365 aa)
	LOC102357497	DUF4203 domain-containing protein. (354 aa)
	CLPX	Caseinolytic mitochondrial matrix peptidase chaperone subunit. (633 aa)
	LOC102367479	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (992 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	TANK	Uncharacterized protein. (72 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRM1	PSMD14	ENSLACP00000010042	ENSLACP00000004737	Adhesion regulating molecule 1.	Proteasome 26S subunit, non-ATPase 14.	0.991
ADRM1	PSME1	ENSLACP00000010042	ENSLACP00000003183	Adhesion regulating molecule 1.	Proteasome activator subunit 1.	0.708
ADRM1	PSME2	ENSLACP00000010042	ENSLACP00000001049	Adhesion regulating molecule 1.	Proteasome activator subunit 2.	0.708
ADRM1	PSME3	ENSLACP00000010042	ENSLACP00000002555	Adhesion regulating molecule 1.	Proteasome activator subunit 3.	0.731
ADRM1	PSME4	ENSLACP00000010042	ENSLACP00000001966	Adhesion regulating molecule 1.	Proteasome activator subunit 4.	0.934
APAF1	LOC102357497	ENSLACP00000014568	ENSLACP00000017947	Apoptotic peptidase activating factor 1.	DUF4203 domain-containing protein.	0.790
APAF1	RACK1	ENSLACP00000014568	ENSLACP00000017186	Apoptotic peptidase activating factor 1.	Receptor for activated C kinase 1.	0.448
APAF1	TMEM198	ENSLACP00000014568	ENSLACP00000017893	Apoptotic peptidase activating factor 1.	Transmembrane protein 198.	0.790
APH1B	LOC102360420	ENSLACP00000013738	ENSLACP00000011952	Aph-1 homolog B, gamma-secretase subunit.	Uncharacterized protein.	0.901
APH1B	PSENEN	ENSLACP00000013738	ENSLACP00000010134	Aph-1 homolog B, gamma-secretase subunit.	Presenilin enhancer, gamma-secretase subunit.	0.988
CAV3	LOC102354291	ENSLACP00000020888	ENSLACP00000002046	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.572
CTSC	CTSH	ENSLACP00000001648	ENSLACP00000006375	Cathepsin C; Belongs to the peptidase C1 family.	Cathepsin H; Belongs to the peptidase C1 family.	0.403
CTSH	CTSC	ENSLACP00000006375	ENSLACP00000001648	Cathepsin H; Belongs to the peptidase C1 family.	Cathepsin C; Belongs to the peptidase C1 family.	0.403
CTSH	H3B0U5_LATCH	ENSLACP00000006375	ENSLACP00000015516	Cathepsin H; Belongs to the peptidase C1 family.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.403
H3AJI4_LATCH	PSENEN	ENSLACP00000009805	ENSLACP00000010134	Uncharacterized protein.	Presenilin enhancer, gamma-secretase subunit.	0.946
H3B0U5_LATCH	CTSH	ENSLACP00000015516	ENSLACP00000006375	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Cathepsin H; Belongs to the peptidase C1 family.	0.403
LOC102354291	CAV3	ENSLACP00000002046	ENSLACP00000020888	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.572
LOC102357497	APAF1	ENSLACP00000017947	ENSLACP00000014568	DUF4203 domain-containing protein.	Apoptotic peptidase activating factor 1.	0.790
LOC102360420	APH1B	ENSLACP00000011952	ENSLACP00000013738	Uncharacterized protein.	Aph-1 homolog B, gamma-secretase subunit.	0.901
LOC102360420	PSENEN	ENSLACP00000011952	ENSLACP00000010134	Uncharacterized protein.	Presenilin enhancer, gamma-secretase subunit.	0.988