(85 nodes) Regulation of transforming growth factor beta receptor signaling pathway network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FBN1	Fibrillin 1. (2872 aa)
	H2ZRM4_LATCH	Uncharacterized protein. (379 aa)
	LOC102350617	Uncharacterized protein. (222 aa)
	LOC102356560	ANK_REP_REGION domain-containing protein. (128 aa)
	LRG1	LRRCT domain-containing protein. (337 aa)
	ADAMTSL2	ADAMTS like 2. (952 aa)
	LOC102363464	Si:ch211-267e7.3. (924 aa)
	LOC102354291	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (169 aa)
	VEPH1-2	Uncharacterized protein. (196 aa)
	RNF111	Ring finger protein 111. (966 aa)
	ITGA3	Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1012 aa)
	WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (575 aa)
	SMAD6	Mothers against decapentaplegic homolog. (485 aa)
	SNX25	Sorting nexin 25. (620 aa)
	ZNF451	Zinc finger protein 451. (1068 aa)
	SMAD7	Mothers against decapentaplegic homolog. (377 aa)
	LOC102352233	Uncharacterized protein. (511 aa)
	TGFBR3	Transforming growth factor beta receptor 3. (808 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (259 aa)
	IL17F	Interleukin 17F. (166 aa)
	LINGO3	Leucine rich repeat and Ig domain containing 3a. (624 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	NRROS	Negative regulator of reactive oxygen species. (691 aa)
	SIRT1	Sirtuin 1. (729 aa)
	FAM89B	Family with sequence similarity 89 member B. (179 aa)
	M3XLP3_LATCH	Uncharacterized protein. (408 aa)
	CREBBP	CREB binding protein. (2411 aa)
	ENG	Endoglin. (674 aa)
	LOC102358988	Mothers against decapentaplegic homolog. (614 aa)
	PRDM16	PR/SET domain 16. (1135 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
	PRDM16-2	Si:ch211-263k4.2. (114 aa)
	ARID4A	AT-rich interaction domain 4A. (1297 aa)
	ZNF703	Zinc finger protein 703. (539 aa)
	PPM1A	Protein phosphatase, Mg2+/Mn2+ dependent 1A. (383 aa)
	SPRED3	Sprouty related EVH1 domain containing 3. (453 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	HSPA5	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
	THBS1	Thrombospondin 1. (1170 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	PMEPA1	Prostate transmembrane protein, androgen induced 1. (284 aa)
	H3BE69_LATCH	PID domain-containing protein. (136 aa)
	BCL9L	BCL9 like. (1514 aa)
	H3BB14_LATCH	Uncharacterized protein. (123 aa)
	GIPC1	GIPC PDZ domain containing family member 1. (333 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (320 aa)
	GIPC3	GIPC PDZ domain containing family member 3. (319 aa)
	SKIL	SKI like proto-oncogene. (691 aa)
	SMURF2	E3 ubiquitin-protein ligase. (754 aa)
	WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (556 aa)
	MYOCD	Myocardin. (963 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
	BBIP1	Uncharacterized protein. (499 aa)
	PBLD	Phenazine biosynthesis like protein domain containing. (288 aa)
	SKI	SKI proto-oncogene. (702 aa)
	VEPH1	Ventricular zone expressed PH domain containing 1. (528 aa)
	SNW1	SNW domain containing 1. (536 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1076 aa)
	GIPC2	GIPC PDZ domain containing family member 2. (327 aa)
	DAB2	DAB adaptor protein 2. (745 aa)
	ING2	Inhibitor of growth protein. (269 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (148 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (163 aa)
	H3AVW8_LATCH	Mothers against decapentaplegic homolog. (369 aa)
	CHST11	Carbohydrate sulfotransferase. (298 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (446 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	C20orf27	Chromosome 20 open reading frame 27. (106 aa)
	HTRA3	HtrA serine peptidase 3. (460 aa)
	SMAD3	Mothers against decapentaplegic homolog. (358 aa)
	LDLRAD4	Low density lipoprotein receptor class A domain containing 4. (310 aa)
	ZBTB7A	Zinc finger and BTB domain containing 7A. (518 aa)
	LEMD3	LEM domain containing 3. (705 aa)
	LATS1	Large tumor suppressor kinase 1. (1140 aa)
	IL17RD	Interleukin 17 receptor D. (698 aa)
	MPP5	Membrane palmitoylated protein 5; Belongs to the MAGUK family. (678 aa)
	EMILIN1	Elastin microfibril interfacer 1. (1047 aa)
	FLCN	Folliculin. (576 aa)
	ADAM17	ADAM metallopeptidase domain 17. (827 aa)
	LOC102352539	Uncharacterized protein. (949 aa)
	SMAD4	MH2 domain-containing protein. (412 aa)
	STRAP	Serine/threonine kinase receptor associated protein. (329 aa)
	LATS2	Large tumor suppressor kinase 2. (1108 aa)
	SLC2A10	Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (535 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM17	SNW1	ENSLACP00000010665	ENSLACP00000015061	ADAM metallopeptidase domain 17.	SNW domain containing 1.	0.465
ARID4A	FBN1	ENSLACP00000021481	ENSLACP00000010136	AT-rich interaction domain 4A.	Fibrillin 1.	0.471
ARID4A	ING2	ENSLACP00000021481	ENSLACP00000014384	AT-rich interaction domain 4A.	Inhibitor of growth protein.	0.750
ARID4A	TGFBR3	ENSLACP00000021481	ENSLACP00000007244	AT-rich interaction domain 4A.	Transforming growth factor beta receptor 3.	0.471
ARID4A	THBS1	ENSLACP00000021481	ENSLACP00000020712	AT-rich interaction domain 4A.	Thrombospondin 1.	0.471
BAMBI	H3AVW8_LATCH	ENSLACP00000007870	ENSLACP00000013789	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.722
BAMBI	LOC102358988	ENSLACP00000007870	ENSLACP00000022115	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.583
BAMBI	SMAD2	ENSLACP00000007870	ENSLACP00000008339	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.519
BAMBI	SMAD3	ENSLACP00000007870	ENSLACP00000011989	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.519
BAMBI	SMAD4	ENSLACP00000007870	ENSLACP00000009312	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	MH2 domain-containing protein.	0.583
BAMBI	SMAD6	ENSLACP00000007870	ENSLACP00000006043	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.763
BAMBI	SMAD7	ENSLACP00000007870	ENSLACP00000006551	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.930
BAMBI	TGFB1	ENSLACP00000007870	ENSLACP00000020652	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.739
CAV1	CAV2	ENSLACP00000014173	ENSLACP00000014086	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.933
CAV1	LOC102354291	ENSLACP00000014173	ENSLACP00000002046	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.564
CAV2	CAV1	ENSLACP00000014086	ENSLACP00000014173	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.933
CAV2	CAV3	ENSLACP00000014086	ENSLACP00000020888	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.976
CAV2	LOC102354291	ENSLACP00000014086	ENSLACP00000002046	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.982
CAV2	LOC102356560	ENSLACP00000014086	ENSLACP00000001382	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	ANK_REP_REGION domain-containing protein.	0.407
CAV3	CAV2	ENSLACP00000020888	ENSLACP00000014086	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.976