STRINGSTRING
LOC102356451 LOC102356451 HMGXB4 HMGXB4 WWTR1 WWTR1 LOC102364406 LOC102364406 LOC102356000 LOC102356000 LGR5 LGR5 TSC2 TSC2 LOC102352836 LOC102352836 OTUD5 OTUD5 LOC102359396 LOC102359396 OTULIN OTULIN PTPRO PTPRO CDC73 CDC73 PLPP3 PLPP3 DLX5 DLX5 LOC102346204 LOC102346204 FZD4 FZD4 STK4 STK4 NKD2 NKD2 TNKS2 TNKS2 TRABD2A TRABD2A LZTS2 LZTS2 CCNY CCNY YAP1 YAP1 APCDD1 APCDD1 MCC MCC GLI3 GLI3 WWTR1-2 WWTR1-2 TTC21B TTC21B ITGA3 ITGA3 SOX10 SOX10 FRZB FRZB H3A657_LATCH H3A657_LATCH NLE1 NLE1 NRARP NRARP ARNTL ARNTL TPBG TPBG WLS WLS LOC102358266 LOC102358266 LEF1 LEF1 SFRP4 SFRP4 APC APC CDK14 CDK14 KPNA1 KPNA1 GSC GSC H3A8H2_LATCH H3A8H2_LATCH LOC102358007 LOC102358007 LOC102365523 LOC102365523 ABL2 ABL2 DKK2 DKK2 WNT5A WNT5A WNT11 WNT11 ILK ILK LOC102353587 LOC102353587 ANKRD6 ANKRD6 GREM1 GREM1 SDHAF2 SDHAF2 CAPRIN2 CAPRIN2 LOC102353948 LOC102353948 CTNNBIP1 CTNNBIP1 SFRP2 SFRP2 H3ACF5_LATCH H3ACF5_LATCH GSK3A GSK3A TMEM64 TMEM64 H3ADV1_LATCH H3ADV1_LATCH BAMBI BAMBI HIC1 HIC1 TMEM170B TMEM170B RNF146 RNF146 TLE3 TLE3 TMEM88 TMEM88 SOX7 SOX7 RECK RECK WNT3 WNT3 VGLL4 VGLL4 CSNK1E CSNK1E H3AHH6_LATCH H3AHH6_LATCH CBY1 CBY1 TNKS TNKS ATP6AP2 ATP6AP2 SULF2 SULF2 APC2 APC2 TNN TNN RSPO3 RSPO3 CSNK1A1 CSNK1A1 SFRP1 SFRP1 LYPD6 LYPD6 H3AJR0_LATCH H3AJR0_LATCH LATS2 LATS2 APCDD1L APCDD1L RNF220 RNF220 PBXIP1 PBXIP1 NPHP3 NPHP3 SOX13 SOX13 H3AMA1_LATCH H3AMA1_LATCH TMEM237 TMEM237 H3AMM4_LATCH H3AMM4_LATCH H3AMS7_LATCH H3AMS7_LATCH CYLD CYLD SFRP1-2 SFRP1-2 H3ANG8_LATCH H3ANG8_LATCH LATS1 LATS1 H3ANQ8_LATCH H3ANQ8_LATCH H3AP48_LATCH H3AP48_LATCH BICC1 BICC1 H3API6_LATCH H3API6_LATCH LOC102363322 LOC102363322 USP47 USP47 SOST SOST MDFIC MDFIC NOTUM NOTUM IFT80 IFT80 SOSTDC1 SOSTDC1 EDA EDA DKK3 DKK3 PSEN1 PSEN1 H3AT06_LATCH H3AT06_LATCH GSK3B GSK3B LOC102346563 LOC102346563 STK11 STK11 AXIN1 AXIN1 H3AUD4_LATCH H3AUD4_LATCH NKD1 NKD1 MDFI MDFI TMEM131L TMEM131L LRRK2 LRRK2 LGR4 LGR4 UBR5 UBR5 PPM1B PPM1B CSNK1G2 CSNK1G2 H3AXS1_LATCH H3AXS1_LATCH ZRANB1 ZRANB1 RUVBL1 RUVBL1 DAB2 DAB2 H3AZB0_LATCH H3AZB0_LATCH LOC102356408 LOC102356408 LOC102356682 LOC102356682 FOXL1 FOXL1 PTK7 PTK7 H3B0X9_LATCH H3B0X9_LATCH SFRP5 SFRP5 CSNK1D CSNK1D CTHRC1 CTHRC1 HHEX HHEX FAM53B FAM53B JADE1 JADE1 TLE5 TLE5 PFDN5 PFDN5 DKK4 DKK4 TNFAIP3 TNFAIP3 LOC102346785 LOC102346785 ZNRF3-2 ZNRF3-2 NKX2-5 NKX2-5 WWOX WWOX CSNK1G1 CSNK1G1 RACK1 RACK1 CTNNB1 CTNNB1 H3B5P8_LATCH H3B5P8_LATCH LGR6 LGR6 ZNRF3 ZNRF3 SOX30 SOX30 KREMEN1 KREMEN1 ABL1 ABL1 AMER1 AMER1 AMER2 AMER2 TMEM198 TMEM198 LOC102357497 LOC102357497 SULF1 SULF1 CCNYL1 CCNYL1 PRDM15 PRDM15 TLE4 TLE4 SHISA2 SHISA2 RNF43 RNF43 LOC102356742 LOC102356742 WNK2 WNK2 XIAP XIAP GID8 GID8 IGFBP6 IGFBP6 LOC102355199 LOC102355199 RSPO1 RSPO1 TBL1XR1 TBL1XR1 H3BC72_LATCH H3BC72_LATCH H3BCC2_LATCH H3BCC2_LATCH LOC102354118 LOC102354118 SCYL2 SCYL2 AXIN2 AXIN2 WNT3A WNT3A BARX1 BARX1 TMEM9 TMEM9 H3BDM4_LATCH H3BDM4_LATCH GPC3 GPC3 H3BE69_LATCH H3BE69_LATCH WNT5B WNT5B TAX1BP3 TAX1BP3 RUVBL2 RUVBL2 C12orf43 C12orf43 HNF1A HNF1A LRRK1 LRRK1 NLK NLK G3BP1 G3BP1 IFT20 IFT20 GSKIP GSKIP FRMD8 FRMD8 H3BFW7_LATCH H3BFW7_LATCH H3BFZ2_LATCH H3BFZ2_LATCH USP8 USP8 CAV3 CAV3 USP34 USP34 PPM1A PPM1A ZNF703 ZNF703 MDK MDK SOX9 SOX9 DIXDC1 DIXDC1 DACT1 DACT1 MKS1 MKS1 DDIT3 DDIT3 GLI1 GLI1 NPHP4 NPHP4 TMEM88B TMEM88B DRAXIN DRAXIN LYPD6B LYPD6B DEPDC1B DEPDC1B TLE1 TLE1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102356451Uncharacterized protein. (208 aa)
HMGXB4HMG-box containing 4. (570 aa)
WWTR1WW domain containing transcription regulator 1. (264 aa)
LOC102364406Uncharacterized protein. (530 aa)
LOC102356000Uncharacterized protein. (211 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (625 aa)
TSC2TSC complex subunit 2. (1836 aa)
LOC102352836RNF220 domain-containing protein. (296 aa)
OTUD5OTU deubiquitinase 5. (534 aa)
LOC102359396Uncharacterized protein. (483 aa)
OTULINOTU deubiquitinase with linear linkage specificity. (225 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1222 aa)
CDC73Cell division cycle 73. (316 aa)
PLPP3Phospholipid phosphatase 3. (285 aa)
DLX5Distal-less homeobox 5. (290 aa)
LOC102346204Protein kinase domain-containing protein. (227 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (530 aa)
STK4Serine/threonine kinase 4. (488 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (387 aa)
TNKS2Poly [ADP-ribose] polymerase. (1174 aa)
TRABD2ATraB domain containing 2A. (193 aa)
LZTS2Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family. (678 aa)
CCNYCyclin Y; Belongs to the cyclin family. (257 aa)
YAP1Yes associated protein 1. (324 aa)
APCDD1APC down-regulated 1. (516 aa)
MCCMCC regulator of WNT signaling pathway. (765 aa)
GLI3GLI family zinc finger 3. (1456 aa)
WWTR1-2WW domain-containing protein. (159 aa)
TTC21BTetratricopeptide repeat domain 21B. (1311 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1012 aa)
SOX10SRY-box transcription factor 10. (451 aa)
FRZBFrizzled related protein. (318 aa)
H3A657_LATCHPH domain-containing protein. (1101 aa)
NLE1Notchless homolog 1. (488 aa)
NRARPNOTCH regulated ankyrin repeat protein. (112 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (635 aa)
TPBGTrophoblast glycoprotein. (386 aa)
WLSWnt ligand secretion mediator. (541 aa)
LOC102358266Dickkopf WNT signaling pathway inhibitor 1b. (261 aa)
LEF1Lymphoid enhancer binding factor 1. (397 aa)
SFRP4Secreted frizzled related protein 4. (198 aa)
APCAPC regulator of WNT signaling pathway. (2802 aa)
CDK14Cyclin dependent kinase 14; Belongs to the protein kinase superfamily. (469 aa)
KPNA1Importin subunit alpha; Belongs to the importin alpha family. (538 aa)
GSCGoosecoid homeobox. (243 aa)
H3A8H2_LATCHUncharacterized protein. (541 aa)
LOC102358007Thioredoxin domain-containing protein. (421 aa)
LOC102365523Uncharacterized protein; Belongs to the peptidase C19 family. (930 aa)
ABL2Tyrosine-protein kinase. (1175 aa)
DKK2Dickkopf WNT signaling pathway inhibitor 2. (212 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (381 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ILKIntegrin linked kinase. (417 aa)
LOC102353587Uncharacterized protein. (490 aa)
ANKRD6Ankyrin repeat domain 6. (791 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (189 aa)
SDHAF2Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (166 aa)
CAPRIN2Caprin family member 2. (1014 aa)
LOC102353948Nemo-like kinase, type 1. (336 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
H3ACF5_LATCHThioredoxin domain-containing protein. (328 aa)
GSK3AGlycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (463 aa)
TMEM64Transmembrane protein 64. (350 aa)
H3ADV1_LATCHTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (974 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (259 aa)
HIC1HIC ZBTB transcriptional repressor 1. (666 aa)
TMEM170BTransmembrane protein 170B. (153 aa)
RNF146Ring finger protein 146. (347 aa)
TLE3TLE family member 3, transcriptional corepressor. (761 aa)
TMEM88Transmembrane protein 88 b. (177 aa)
SOX7SRY-box transcription factor 7. (369 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (952 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
VGLL4Vestigial like family member 4. (293 aa)
CSNK1ECasein kinase 1, epsilon; Belongs to the protein kinase superfamily. (418 aa)
H3AHH6_LATCHRHD domain-containing protein. (288 aa)
CBY1Uncharacterized protein. (127 aa)
TNKSPoly [ADP-ribose] polymerase. (1233 aa)
ATP6AP2ATPase H+ transporting accessory protein 2. (367 aa)
SULF2Extracellular sulfatase. (877 aa)
APC2APC regulator of WNT signaling pathway 2. (2366 aa)
TNNTenascin N. (831 aa)
RSPO3R-spondin 3. (213 aa)
CSNK1A1Casein kinase 1 alpha 1. (287 aa)
SFRP1NTR domain-containing protein. (128 aa)
LYPD6LY6/PLAUR domain containing 6. (171 aa)
H3AJR0_LATCHSRY-box transcription factor 13. (427 aa)
LATS2Large tumor suppressor kinase 2. (1108 aa)
APCDD1LAPC down-regulated 1 like. (497 aa)
RNF220Ring finger protein 220. (231 aa)
PBXIP1Uncharacterized protein. (891 aa)
NPHP3Nephronophthisis 3. (1314 aa)
SOX13Uncharacterized protein. (195 aa)
H3AMA1_LATCHUncharacterized protein. (612 aa)
TMEM237Transmembrane protein 237. (400 aa)
H3AMM4_LATCHHomeobox domain-containing protein. (194 aa)
H3AMS7_LATCHUncharacterized protein. (149 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (959 aa)
SFRP1-2FZ domain-containing protein. (203 aa)
H3ANG8_LATCHUncharacterized protein. (321 aa)
LATS1Large tumor suppressor kinase 1. (1140 aa)
H3ANQ8_LATCHMCC-bdg_PDZ domain-containing protein. (754 aa)
H3AP48_LATCHDickkopf_N domain-containing protein. (253 aa)
BICC1BicC family RNA binding protein 1. (869 aa)
H3API6_LATCHUncharacterized protein. (109 aa)
LOC102363322Uncharacterized protein. (509 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1381 aa)
SOSTSclerostin. (210 aa)
MDFICUncharacterized protein. (250 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (506 aa)
IFT80Intraflagellar transport 80. (780 aa)
SOSTDC1Sclerostin domain containing 1. (213 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (223 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (349 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
H3AT06_LATCHUncharacterized protein. (88 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
LOC102346563Protein tyrosine phosphatase receptor type Ua. (913 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
AXIN1Axin 1. (880 aa)
H3AUD4_LATCHPPM-type phosphatase domain-containing protein. (321 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (370 aa)
MDFIMyoD family inhibitor. (156 aa)
TMEM131LTransmembrane 131 like. (1522 aa)
LRRK2Leucine rich repeat kinase 2. (2508 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (955 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2787 aa)
PPM1BPPM-type phosphatase domain-containing protein. (474 aa)
CSNK1G2Casein kinase 1 gamma 2; Belongs to the protein kinase superfamily. (458 aa)
H3AXS1_LATCHProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (313 aa)
ZRANB1Zinc finger RANBP2-type containing 1. (709 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (467 aa)
DAB2DAB adaptor protein 2. (745 aa)
H3AZB0_LATCHGlypican 5c; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (263 aa)
LOC102356408Uncharacterized protein. (711 aa)
LOC102356682TLE family member 2, transcriptional corepressor b. (743 aa)
FOXL1Forkhead box L1. (463 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1067 aa)
H3B0X9_LATCHUncharacterized protein. (786 aa)
SFRP5Secreted frizzled related protein 5. (309 aa)
CSNK1DCasein kinase 1 delta. (417 aa)
CTHRC1Collagen triple helix repeat containing 1. (151 aa)
HHEXHematopoietically expressed homeobox. (276 aa)
FAM53BFamily with sequence similarity 53 member B. (292 aa)
JADE1Jade family PHD finger 1. (864 aa)
TLE5TLE family member 5, transcriptional modulator. (202 aa)
PFDN5Prefoldin subunit 5. (155 aa)
DKK4Dickkopf WNT signaling pathway inhibitor 4. (222 aa)
TNFAIP3TNF alpha induced protein 3. (785 aa)
LOC102346785Trophoblast glycoprotein a. (373 aa)
ZNRF3-2Uncharacterized protein. (79 aa)
NKX2-5NK2 homeobox 5. (296 aa)
WWOXWW domain containing oxidoreductase. (353 aa)
CSNK1G1Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (456 aa)
RACK1Receptor for activated C kinase 1. (317 aa)
CTNNB1Catenin beta 1. (781 aa)
H3B5P8_LATCHZNRF_3_ecto domain-containing protein. (60 aa)
LGR6Leucine rich repeat containing G protein-coupled receptor 6. (893 aa)
ZNRF3Zinc and ring finger 3. (698 aa)
SOX30SRY-box transcription factor 30. (596 aa)
KREMEN1Kringle containing transmembrane protein 1. (249 aa)
ABL1Tyrosine-protein kinase. (1156 aa)
AMER1APC membrane recruitment protein 1. (900 aa)
AMER2APC membrane recruitment protein 2. (641 aa)
TMEM198Transmembrane protein 198. (365 aa)
LOC102357497DUF4203 domain-containing protein. (354 aa)
SULF1Sulfatase 1. (1129 aa)
CCNYL1Cyclin Y like 1; Belongs to the cyclin family. (343 aa)
PRDM15PR/SET domain 15. (1169 aa)
TLE4Uncharacterized protein. (734 aa)
SHISA2Shisa family member 2. (295 aa)
RNF43RING-type domain-containing protein. (626 aa)
LOC102356742Sizzled. (295 aa)
WNK2WNK lysine deficient protein kinase 2. (1994 aa)
XIAPX-linked inhibitor of apoptosis. (606 aa)
GID8GID complex subunit 8 homolog. (190 aa)
IGFBP6Insulin like growth factor binding protein 6. (271 aa)
LOC102355199Uncharacterized protein. (301 aa)
RSPO1R-spondin 1. (249 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (515 aa)
H3BC72_LATCHUncharacterized protein. (193 aa)
H3BCC2_LATCHUncharacterized protein. (314 aa)
LOC102354118Dickkopf_N domain-containing protein. (243 aa)
SCYL2SCY1 like pseudokinase 2. (939 aa)
AXIN2Axin 2. (841 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
BARX1BARX homeobox 1. (250 aa)
TMEM9Transmembrane protein 9. (191 aa)
H3BDM4_LATCHUncharacterized protein. (109 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (270 aa)
H3BE69_LATCHPID domain-containing protein. (136 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
TAX1BP3Tax1 binding protein 3. (123 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (466 aa)
C12orf43Chromosome 12 open reading frame 43. (282 aa)
HNF1AHNF1 homeobox A. (624 aa)
LRRK1Leucine rich repeat kinase 1. (1987 aa)
NLKMitogen-activated protein kinase. (382 aa)
G3BP1G3BP stress granule assembly factor 1. (481 aa)
IFT20Intraflagellar transport 20. (132 aa)
GSKIPGSK3B interacting protein. (144 aa)
FRMD8FERM domain containing 8. (465 aa)
H3BFW7_LATCHBHLH domain-containing protein. (161 aa)
H3BFZ2_LATCHBHLH domain-containing protein. (165 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1102 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
USP34Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (2994 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (383 aa)
ZNF703Zinc finger protein 703. (539 aa)
MDKMidkine. (141 aa)
SOX9SRY-box transcription factor 9. (475 aa)
DIXDC1DIX domain containing 1. (695 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (815 aa)
MKS1MKS transition zone complex subunit 1. (561 aa)
DDIT3DNA damage inducible transcript 3. (256 aa)
GLI1GLI family zinc finger 1. (1380 aa)
NPHP4Nephrocystin 4. (1207 aa)
TMEM88BUncharacterized protein. (143 aa)
DRAXINDorsal inhibitory axon guidance protein. (347 aa)
LYPD6BLY6/PLAUR domain containing 6B. (134 aa)
DEPDC1BDEP domain containing 1B. (529 aa)
TLE1Uncharacterized protein. (655 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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