(90 nodes) T cell differentiation network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD3E	CD3e molecule. (191 aa)
	RC3H2	RING-type domain-containing protein. (352 aa)
	H2ZSX8_LATCH	Fibronectin type-III domain-containing protein. (243 aa)
	TMEM98	Transmembrane protein 98. (226 aa)
	NCAPH2	Non-SMC condensin II complex subunit H2. (617 aa)
	H2ZV40_LATCH	Protein kinase domain-containing protein. (266 aa)
	FZD8	Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	IRF1	Interferon regulatory factor. (264 aa)
	GPR183	G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	PTGER4	Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (455 aa)
	GPR18	G protein-coupled receptor 18. (330 aa)
	EOMES	Eomesodermin. (419 aa)
	GATA3	GATA binding protein 3. (447 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (830 aa)
	LIG4	DNA ligase. (911 aa)
	ARMC5	Armadillo repeat containing 5. (811 aa)
	GLI3	GLI family zinc finger 3. (1456 aa)
	CARD11	Caspase recruitment domain family member 11. (1137 aa)
	LOC102358239	TRAF3 interacting protein 2-like. (392 aa)
	KIT	KIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (937 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (567 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1045 aa)
	NRARP	NOTCH regulated ankyrin repeat protein. (112 aa)
	RAG2	Recombination activating 2. (522 aa)
	LEF1	Lymphoid enhancer binding factor 1. (397 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (397 aa)
	LOC102359113	Uncharacterized protein. (455 aa)
	LOC102362196	Ig-like domain-containing protein. (206 aa)
	NHEJ1	Uncharacterized protein. (303 aa)
	ABL2	Tyrosine-protein kinase. (1175 aa)
	CCR9	C-C motif chemokine receptor 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	LEPR	Leptin receptor. (1149 aa)
	ZAP70	Tyrosine-protein kinase. (609 aa)
	H3AGM7_LATCH	Fibronectin type-III domain-containing protein. (234 aa)
	PKNOX1	PBX/knotted 1 homeobox 1. (436 aa)
	IL6	Uncharacterized protein. (149 aa)
	IL18R1	TIR domain-containing protein. (153 aa)
	H3AJR0_LATCH	SRY-box transcription factor 13. (427 aa)
	FADD	Fas associated via death domain. (193 aa)
	RSAD2	Radical S-adenosyl methionine domain containing 2. (360 aa)
	HLX	H2.0 like homeobox. (384 aa)
	LOC102346566	Annexin. (343 aa)
	TOX	Thymocyte selection associated high mobility group box. (392 aa)
	SOX13	Uncharacterized protein. (195 aa)
	PAX1	Paired box 1. (362 aa)
	THEMIS	Thymocyte selection associated. (564 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	SP3	Sp3 transcription factor. (785 aa)
	RHOH	Ras homolog family member H. (189 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (768 aa)
	TSC1	TSC complex subunit 1. (1217 aa)
	IKZF3	IKAROS family zinc finger 3. (507 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (442 aa)
	TRAF3IP2	SEFIR domain-containing protein. (379 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	LOC102348796	Uncharacterized protein. (497 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (688 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1106 aa)
	NKX2-3	NK2 homeobox 3. (334 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	JMJD6	Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (403 aa)
	SASH3	SAM and SH3 domain containing 3. (433 aa)
	SEMA4A	Sema domain-containing protein; Belongs to the semaphorin family. (758 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
	SRF	Serum response factor. (520 aa)
	TESPA1	KRAP_IP3R_bind domain-containing protein. (96 aa)
	H3B480_LATCH	Uncharacterized protein. (567 aa)
	PSMB11	Proteasome subunit beta. (269 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	LOC102358862	Proteasome subunit beta. (272 aa)
	RABL3	RAB, member of RAS oncogene family like 3. (218 aa)
	ABL1	Tyrosine-protein kinase. (1156 aa)
	CD74	CD74 molecule. (279 aa)
	H3B8U3_LATCH	Serine/threonine-protein kinase TOR. (1418 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1123 aa)
	ZBTB1	Zinc finger and BTB domain containing 1. (706 aa)
	LOC102363206	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
	MTOR	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
	TCF7	Transcription factor 7. (343 aa)
	TBX21	T-box transcription factor 21. (570 aa)
	RORA	RAR related orphan receptor A. (468 aa)
	RORC	RAR related orphan receptor C. (502 aa)
	BATF	Basic leucine zipper ATF-like transcription factor. (119 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	H3BH49_LATCH	Ig-like domain-containing protein. (195 aa)
	H3BI75_LATCH	Uncharacterized protein. (110 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
	IL6R	Interleukin 6 receptor. (469 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ABL2	ENSLACP00000017765	ENSLACP00000006377	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
ABL1	CTNNB1	ENSLACP00000017765	ENSLACP00000017209	Tyrosine-protein kinase.	Catenin beta 1.	0.684
ABL1	RHOH	ENSLACP00000017765	ENSLACP00000012746	Tyrosine-protein kinase.	Ras homolog family member H.	0.412
ABL1	TP53	ENSLACP00000017765	ENSLACP00000015915	Tyrosine-protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.448
ABL2	ABL1	ENSLACP00000006377	ENSLACP00000017765	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
ABL2	CTNNB1	ENSLACP00000006377	ENSLACP00000017209	Tyrosine-protein kinase.	Catenin beta 1.	0.684
ABL2	RHOH	ENSLACP00000006377	ENSLACP00000012746	Tyrosine-protein kinase.	Ras homolog family member H.	0.412
ABL2	TP53	ENSLACP00000006377	ENSLACP00000015915	Tyrosine-protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.448
ATG5	FADD	ENSLACP00000015035	ENSLACP00000009943	Autophagy protein 5; Involved in autophagic vesicle formation.	Fas associated via death domain.	0.794
ATG5	H3B8U3_LATCH	ENSLACP00000015035	ENSLACP00000018314	Autophagy protein 5; Involved in autophagic vesicle formation.	Serine/threonine-protein kinase TOR.	0.453
ATG5	MTOR	ENSLACP00000015035	ENSLACP00000018843	Autophagy protein 5; Involved in autophagic vesicle formation.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.453
ATG5	TP53	ENSLACP00000015035	ENSLACP00000015915	Autophagy protein 5; Involved in autophagic vesicle formation.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.434
BATF	EOMES	ENSLACP00000020255	ENSLACP00000003120	Basic leucine zipper ATF-like transcription factor.	Eomesodermin.	0.503
BATF	GATA3	ENSLACP00000020255	ENSLACP00000003446	Basic leucine zipper ATF-like transcription factor.	GATA binding protein 3.	0.480
BATF	H3B480_LATCH	ENSLACP00000020255	ENSLACP00000016701	Basic leucine zipper ATF-like transcription factor.	Uncharacterized protein.	0.607
BATF	RORA	ENSLACP00000020255	ENSLACP00000019843	Basic leucine zipper ATF-like transcription factor.	RAR related orphan receptor A.	0.530
BATF	STAT3	ENSLACP00000020255	ENSLACP00000013656	Basic leucine zipper ATF-like transcription factor.	Signal transducer and activator of transcription.	0.532
BRAF	CTNNB1	ENSLACP00000012774	ENSLACP00000017209	B-Raf proto-oncogene, serine/threonine kinase.	Catenin beta 1.	0.532
BRAF	STAT3	ENSLACP00000012774	ENSLACP00000013656	B-Raf proto-oncogene, serine/threonine kinase.	Signal transducer and activator of transcription.	0.552
BRAF	TP53	ENSLACP00000012774	ENSLACP00000015915	B-Raf proto-oncogene, serine/threonine kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.686