(28 nodes) Osteoclast differentiation network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2ZTF7_LATCH	Fam20C domain-containing protein. (511 aa)
	JUNB	JunB proto-oncogene, AP-1 transcription factor subunit. (311 aa)
	ATP6AP1	ATPase H+ transporting accessory protein 1. (474 aa)
	GPR183	G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	GLO1	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (186 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (559 aa)
	FAM20C	Fam20C domain-containing protein. (305 aa)
	GAB2	GRB2 associated binding protein 2. (550 aa)
	TMEM64	Transmembrane protein 64. (350 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (169 aa)
	FARP2	FERM, ARH/RhoGEF and pleckstrin domain protein 2. (697 aa)
	LOC102358523	Uncharacterized protein. (424 aa)
	EPHA2	Uncharacterized protein. (979 aa)
	SH3PXD2A	SH3 and PX domains 2A. (1118 aa)
	EFNA2	Ephrin A2; Belongs to the ephrin family. (139 aa)
	CSF1R	Colony stimulating factor 1 receptor. (968 aa)
	SNX10	Sorting nexin 10. (203 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	CREB1	cAMP responsive element binding protein 1. (347 aa)
	H3BAX4_LATCH	DC_STAMP domain-containing protein. (450 aa)
	LOC102356247	Uncharacterized protein. (636 aa)
	TCTA	T-cell leukemia translocation-altered gene protein homolog. (102 aa)
	LRRK1	Leucine rich repeat kinase 1. (1987 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (391 aa)
	NF1	Neurofibromin 1. (2814 aa)
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREB1	CTNNB1	ENSLACP00000018100	ENSLACP00000017209	cAMP responsive element binding protein 1.	Catenin beta 1.	0.677
CREB1	FOS	ENSLACP00000018100	ENSLACP00000020665	cAMP responsive element binding protein 1.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.805
CREB1	JUNB	ENSLACP00000018100	ENSLACP00000001704	cAMP responsive element binding protein 1.	JunB proto-oncogene, AP-1 transcription factor subunit.	0.476
CSF1R	LOC102356247	ENSLACP00000016266	ENSLACP00000022371	Colony stimulating factor 1 receptor.	Uncharacterized protein.	0.951
CSF1R	TNFSF11	ENSLACP00000016266	ENSLACP00000009224	Colony stimulating factor 1 receptor.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.706
CTNNB1	CREB1	ENSLACP00000017209	ENSLACP00000018100	Catenin beta 1.	cAMP responsive element binding protein 1.	0.677
CTNNB1	EPHA2	ENSLACP00000017209	ENSLACP00000013291	Catenin beta 1.	Uncharacterized protein.	0.402
CTNNB1	TGFB1	ENSLACP00000017209	ENSLACP00000020652	Catenin beta 1.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.540
EFNA2	EPHA2	ENSLACP00000014778	ENSLACP00000013291	Ephrin A2; Belongs to the ephrin family.	Uncharacterized protein.	0.889
EPHA2	CTNNB1	ENSLACP00000013291	ENSLACP00000017209	Uncharacterized protein.	Catenin beta 1.	0.402
EPHA2	EFNA2	ENSLACP00000013291	ENSLACP00000014778	Uncharacterized protein.	Ephrin A2; Belongs to the ephrin family.	0.889
FAM20C	LOC102356247	ENSLACP00000004001	ENSLACP00000022371	Fam20C domain-containing protein.	Uncharacterized protein.	0.540
FOS	CREB1	ENSLACP00000020665	ENSLACP00000018100	Fos proto-oncogene, AP-1 transcription factor subunit.	cAMP responsive element binding protein 1.	0.805
FOS	JUNB	ENSLACP00000020665	ENSLACP00000001704	Fos proto-oncogene, AP-1 transcription factor subunit.	JunB proto-oncogene, AP-1 transcription factor subunit.	0.987
FOS	TNFSF11	ENSLACP00000020665	ENSLACP00000009224	Fos proto-oncogene, AP-1 transcription factor subunit.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.544
H2ZTF7_LATCH	LOC102356247	ENSLACP00000000678	ENSLACP00000022371	Fam20C domain-containing protein.	Uncharacterized protein.	0.540
H3AEV1_LATCH	TNFSF11	ENSLACP00000008172	ENSLACP00000009224	TNF_2 domain-containing protein.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.448
JUNB	CREB1	ENSLACP00000001704	ENSLACP00000018100	JunB proto-oncogene, AP-1 transcription factor subunit.	cAMP responsive element binding protein 1.	0.476
JUNB	FOS	ENSLACP00000001704	ENSLACP00000020665	JunB proto-oncogene, AP-1 transcription factor subunit.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.987
LOC102356247	CSF1R	ENSLACP00000022371	ENSLACP00000016266	Uncharacterized protein.	Colony stimulating factor 1 receptor.	0.951