STRINGSTRING
H3BEX6_LATCH H3BEX6_LATCH CCN2 CCN2 TAB1 TAB1 CCBE1 CCBE1 LOC102363464 LOC102363464 DNAAF1 DNAAF1 GATA6 GATA6 EPAS1 EPAS1 H2ZZY5_LATCH H2ZZY5_LATCH H3A007_LATCH H3A007_LATCH BAG6 BAG6 ATXN1L ATXN1L RXFP1 RXFP1 GLI3 GLI3 PKD1 PKD1 TGFBR2 TGFBR2 RDH10 RDH10 ITGA3 ITGA3 DLG5 DLG5 TCF21 TCF21 THRB THRB CTSH CTSH LOC102356182 LOC102356182 ERRFI1 ERRFI1 SEC24B SEC24B ELK1 ELK1 FGF8 FGF8 IGFBP5 IGFBP5 PHF14 PHF14 H3AFZ1_LATCH H3AFZ1_LATCH HPS1 HPS1 LOC102352539 LOC102352539 TTC25 TTC25 HSPB11 HSPB11 ADAMTSL2 ADAMTSL2 RBBP9 RBBP9 SLC7A11 SLC7A11 AIMP2 AIMP2 KDR KDR THRA THRA SP3 SP3 LOC102362376 LOC102362376 NUMA1 NUMA1 FBXW9 FBXW9 SAV1 SAV1 FGF1 FGF1 JMJD6 JMJD6 FGF18 FGF18 PTK7 PTK7 MYOCD MYOCD H3B277_LATCH H3B277_LATCH FNDC3B FNDC3B FGF7 FGF7 DAG1 DAG1 HHIP HHIP SRF SRF CTSZ CTSZ BMPR2 BMPR2 CTNNB1 CTNNB1 SPRY1 SPRY1 PKDCC PKDCC WNT2 WNT2 CREB1 CREB1 STK40 STK40 NKX2-8 NKX2-8 FGF2 FGF2 HOXA5 HOXA5 RC3H2 RC3H2 ZFPM2 ZFPM2 ESRP2 ESRP2 LOC102354477 LOC102354477 CCDC40 CCDC40 ITGB6 ITGB6 STRA6 STRA6 TMEM38B TMEM38B FLT4 FLT4 MMP14 MMP14 FBXW7 FBXW7 GLI1 GLI1 TIMELESS TIMELESS H3BI75_LATCH H3BI75_LATCH HSD11B1 HSD11B1 TGFB1 TGFB1 WNT2B WNT2B LOC102363355 LOC102363355
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H3BEX6_LATCHReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (307 aa)
CCN2Cellular communication network factor 2. (344 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (436 aa)
CCBE1Collagen and calcium binding EGF domains 1. (357 aa)
LOC102363464Si:ch211-267e7.3. (924 aa)
DNAAF1Dynein assembly factor 1, axonemal. (263 aa)
GATA6GATA binding protein 6. (503 aa)
EPAS1Endothelial PAS domain protein 1. (861 aa)
H2ZZY5_LATCHUncharacterized protein. (548 aa)
H3A007_LATCHUncharacterized protein. (52 aa)
BAG6BCL2 associated athanogene 6. (995 aa)
ATXN1LAtaxin 1 like. (727 aa)
RXFP1Relaxin family peptide receptor 1. (626 aa)
GLI3GLI family zinc finger 3. (1456 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4241 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (348 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1012 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1821 aa)
TCF21Transcription factor 21. (179 aa)
THRBThyroid hormone receptor beta. (397 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (329 aa)
LOC102356182Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (196 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (468 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1197 aa)
ELK1ETS transcription factor ELK1. (520 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
IGFBP5Insulin like growth factor binding protein 5. (279 aa)
PHF14PHD finger protein 14. (912 aa)
H3AFZ1_LATCHPeptidase S72 domain-containing protein. (633 aa)
HPS1HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. (699 aa)
LOC102352539Uncharacterized protein. (949 aa)
TTC25Tetratricopeptide repeat domain 25. (578 aa)
HSPB11Zgc:158640. (142 aa)
ADAMTSL2ADAMTS like 2. (952 aa)
RBBP9RB binding protein 9, serine hydrolase. (204 aa)
SLC7A11Solute carrier family 7 member 11. (501 aa)
AIMP2Aminoacyl tRNA synthetase complex interacting multifunctional protein 2. (317 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
THRAThyroid hormone receptor alpha. (408 aa)
SP3Sp3 transcription factor. (785 aa)
LOC102362376Protein kinase domain containing, cytoplasmic b. (381 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2155 aa)
FBXW9F-box and WD repeat domain containing 9. (465 aa)
SAV1Salvador family WW domain containing protein 1. (393 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (403 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1067 aa)
MYOCDMyocardin. (963 aa)
H3B277_LATCHUncharacterized protein. (4290 aa)
FNDC3BFibronectin type III domain containing 3B. (944 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
DAG1Dystroglycan 1. (900 aa)
HHIPHedgehog interacting protein. (687 aa)
SRFSerum response factor. (520 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (295 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
CTNNB1Catenin beta 1. (781 aa)
SPRY1Sprouty RTK signaling antagonist 1. (320 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (503 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
CREB1cAMP responsive element binding protein 1. (347 aa)
STK40Serine/threonine kinase 40. (445 aa)
NKX2-8NK2 homeobox 8. (225 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
HOXA5Homeobox A5. (269 aa)
RC3H2RING-type domain-containing protein. (352 aa)
ZFPM2Zinc finger protein, FOG family member 2. (979 aa)
ESRP2Epithelial splicing regulatory protein 2. (721 aa)
LOC102354477Uncharacterized protein. (838 aa)
CCDC40Coiled-coil domain containing 40. (859 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (675 aa)
STRA6Stimulated by retinoic acid 6. (664 aa)
TMEM38BTransmembrane protein 38B. (302 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1394 aa)
MMP14Matrix metallopeptidase 14. (597 aa)
FBXW7F-box and WD repeat domain containing 7. (713 aa)
GLI1GLI family zinc finger 1. (1380 aa)
TIMELESSTimeless circadian regulator. (1272 aa)
H3BI75_LATCHUncharacterized protein. (110 aa)
HSD11B1Hydroxysteroid 11-beta dehydrogenase 1. (293 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
LOC102363355ETS domain-containing protein. (380 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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