STRINGSTRING
PBLD PBLD BBIP1 BBIP1 TP53 TP53 WFIKKN1 WFIKKN1 SMURF2 SMURF2 SPRY1 SPRY1 H3BB14_LATCH H3BB14_LATCH BCL9L BCL9L PMEPA1 PMEPA1 HSPA5 HSPA5 CAV3 CAV3 SPRED3 SPRED3 PPM1A PPM1A ARID4A ARID4A PRDM16-2 PRDM16-2 WNT1 WNT1 PRDM16 PRDM16 M3XLP3_LATCH M3XLP3_LATCH SKIL SKIL H2ZRM4_LATCH H2ZRM4_LATCH LOC102350617 LOC102350617 LOC102363464 LOC102363464 LOC102354291 LOC102354291 VEPH1-2 VEPH1-2 WFIKKN2 WFIKKN2 SMAD6 SMAD6 SNX25 SNX25 ZNF451 ZNF451 SMAD7 SMAD7 LOC102352233 LOC102352233 BAMBI BAMBI LINGO3 LINGO3 NRROS NRROS SIRT1 SIRT1 STRAP STRAP SLC2A10 SLC2A10 FBN1 FBN1 ADAMTSL2 ADAMTSL2 FAM89B FAM89B ADAM17 ADAM17 EMILIN1 EMILIN1 IL17RD IL17RD LEMD3 LEMD3 ZBTB7A ZBTB7A LDLRAD4 LDLRAD4 HTRA3 HTRA3 PPARA PPARA SPRED1 SPRED1 CHST11 CHST11 H3AVW8_LATCH H3AVW8_LATCH CAV2 CAV2 VEPH1 VEPH1 SKI SKI
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PBLDPhenazine biosynthesis like protein domain containing. (288 aa)
BBIP1Uncharacterized protein. (499 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (556 aa)
SMURF2E3 ubiquitin-protein ligase. (754 aa)
SPRY1Sprouty RTK signaling antagonist 1. (320 aa)
H3BB14_LATCHUncharacterized protein. (123 aa)
BCL9LBCL9 like. (1514 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (284 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
SPRED3Sprouty related EVH1 domain containing 3. (453 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (383 aa)
ARID4AAT-rich interaction domain 4A. (1297 aa)
PRDM16-2Si:ch211-263k4.2. (114 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
PRDM16PR/SET domain 16. (1135 aa)
M3XLP3_LATCHUncharacterized protein. (408 aa)
SKILSKI like proto-oncogene. (691 aa)
H2ZRM4_LATCHUncharacterized protein. (379 aa)
LOC102350617Uncharacterized protein. (222 aa)
LOC102363464Si:ch211-267e7.3. (924 aa)
LOC102354291Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (169 aa)
VEPH1-2Uncharacterized protein. (196 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (575 aa)
SMAD6Mothers against decapentaplegic homolog. (485 aa)
SNX25Sorting nexin 25. (620 aa)
ZNF451Zinc finger protein 451. (1068 aa)
SMAD7Mothers against decapentaplegic homolog. (377 aa)
LOC102352233Uncharacterized protein. (511 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (259 aa)
LINGO3Leucine rich repeat and Ig domain containing 3a. (624 aa)
NRROSNegative regulator of reactive oxygen species. (691 aa)
SIRT1Sirtuin 1. (729 aa)
STRAPSerine/threonine kinase receptor associated protein. (329 aa)
SLC2A10Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (535 aa)
FBN1Fibrillin 1. (2872 aa)
ADAMTSL2ADAMTS like 2. (952 aa)
FAM89BFamily with sequence similarity 89 member B. (179 aa)
ADAM17ADAM metallopeptidase domain 17. (827 aa)
EMILIN1Elastin microfibril interfacer 1. (1047 aa)
IL17RDInterleukin 17 receptor D. (698 aa)
LEMD3LEM domain containing 3. (705 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (518 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (310 aa)
HTRA3HtrA serine peptidase 3. (460 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
SPRED1Sprouty related EVH1 domain containing 1. (446 aa)
CHST11Carbohydrate sulfotransferase. (298 aa)
H3AVW8_LATCHMothers against decapentaplegic homolog. (369 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (163 aa)
VEPH1Ventricular zone expressed PH domain containing 1. (528 aa)
SKISKI proto-oncogene. (702 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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