(21 nodes) Intracellular steroid hormone receptor signaling pathway network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PGR	Progesterone receptor. (770 aa)
	RBFOX2	RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events. (383 aa)
	RWDD1	RWD domain containing 1. (239 aa)
	CYP7B1	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (480 aa)
	PHB	Prohibitin. (272 aa)
	DDX17	Uncharacterized protein; Belongs to the DEAD box helicase family. (699 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	CALCOCO1	Calcium binding and coiled-coil domain 1. (707 aa)
	TRERF1	Transcriptional regulating factor 1. (1190 aa)
	H3AM65_LATCH	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (472 aa)
	PPARGC1B	PPARG coactivator 1 beta. (986 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1401 aa)
	UBR5	Ubiquitin protein ligase E3 component n-recognin 5. (2787 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (907 aa)
	ESR2	Estrogen receptor 2. (583 aa)
	TMF1	TATA element modulatory factor 1. (1135 aa)
	TRIP4	Thyroid hormone receptor interactor 4. (578 aa)
	DAXX	Death-domain associated protein. (728 aa)
	AR	Androgen receptor. (412 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (512 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (770 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	DAXX	ENSLACP00000017054	ENSLACP00000001216	Androgen receptor.	Death-domain associated protein.	0.509
AR	ESR2	ENSLACP00000017054	ENSLACP00000022358	Androgen receptor.	Estrogen receptor 2.	0.615
AR	H3AM65_LATCH	ENSLACP00000017054	ENSLACP00000010736	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.569
AR	MED1	ENSLACP00000017054	ENSLACP00000013232	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.569
AR	NR3C1	ENSLACP00000017054	ENSLACP00000017638	Androgen receptor.	Nuclear receptor subfamily 3 group C member 1.	0.673
AR	PGR	ENSLACP00000017054	ENSLACP00000022009	Androgen receptor.	Progesterone receptor.	0.697
DAXX	AR	ENSLACP00000001216	ENSLACP00000017054	Death-domain associated protein.	Androgen receptor.	0.509
DAXX	NR3C1	ENSLACP00000001216	ENSLACP00000017638	Death-domain associated protein.	Nuclear receptor subfamily 3 group C member 1.	0.558
DDX17	DDX5	ENSLACP00000007440	ENSLACP00000017080	Uncharacterized protein; Belongs to the DEAD box helicase family.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.920
DDX17	ESR2	ENSLACP00000007440	ENSLACP00000022358	Uncharacterized protein; Belongs to the DEAD box helicase family.	Estrogen receptor 2.	0.747
DDX5	DDX17	ENSLACP00000017080	ENSLACP00000007440	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.920
DDX5	ESR2	ENSLACP00000017080	ENSLACP00000022358	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor 2.	0.747
ESR2	AR	ENSLACP00000022358	ENSLACP00000017054	Estrogen receptor 2.	Androgen receptor.	0.615
ESR2	DDX17	ENSLACP00000022358	ENSLACP00000007440	Estrogen receptor 2.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.747
ESR2	DDX5	ENSLACP00000022358	ENSLACP00000017080	Estrogen receptor 2.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.747
ESR2	GPER1	ENSLACP00000022358	ENSLACP00000008155	Estrogen receptor 2.	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.738
ESR2	H3AM65_LATCH	ENSLACP00000022358	ENSLACP00000010736	Estrogen receptor 2.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.800
ESR2	MED1	ENSLACP00000022358	ENSLACP00000013232	Estrogen receptor 2.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.800
ESR2	NR3C1	ENSLACP00000022358	ENSLACP00000017638	Estrogen receptor 2.	Nuclear receptor subfamily 3 group C member 1.	0.445
ESR2	PGR	ENSLACP00000022358	ENSLACP00000022009	Estrogen receptor 2.	Progesterone receptor.	0.960