(96 nodes) Intracellular receptor signaling pathway network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TRIP4	Thyroid hormone receptor interactor 4. (578 aa)
	LOC102349715	Uncharacterized protein. (423 aa)
	LSM14A	LSM14A mRNA processing body assembly factor. (483 aa)
	NR5A2	Nuclear receptor subfamily 5 group A member 2. (394 aa)
	DDX58	DExD/H-box helicase 58. (944 aa)
	H2ZTF8_LATCH	BHLH domain-containing protein. (84 aa)
	OTULIN	OTU deubiquitinase with linear linkage specificity. (225 aa)
	DAXX	Death-domain associated protein. (728 aa)
	LOC102364341	Uncharacterized protein. (271 aa)
	H2ZZF1_LATCH	PAS domain-containing protein. (1038 aa)
	AHR	Aryl hydrocarbon receptor 1a. (868 aa)
	NR1D2	Nuclear receptor subfamily 1 group D member 2. (592 aa)
	H3A246_LATCH	Uncharacterized protein. (920 aa)
	RBFOX2	RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events. (383 aa)
	HNF4G	Hepatocyte nuclear factor 4 gamma. (332 aa)
	H3A2Q0_LATCH	Nuclear receptor domain-containing protein. (83 aa)
	RWDD1	RWD domain containing 1. (239 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (567 aa)
	NR4A3	Nuclear receptor subfamily 4 group A member 3. (592 aa)
	ALPK1	Alpha kinase 1. (1236 aa)
	CYP7B1	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (480 aa)
	FAM120B	Family with sequence similarity 120B. (834 aa)
	THRB	Thyroid hormone receptor beta. (397 aa)
	PHB	Prohibitin. (272 aa)
	RORB	RAR related orphan receptor B. (463 aa)
	RARA	Retinoic acid receptor alpha. (505 aa)
	RARB	NR LBD domain-containing protein. (299 aa)
	PDK3	Protein-serine/threonine kinase. (407 aa)
	DDX17	Uncharacterized protein; Belongs to the DEAD box helicase family. (699 aa)
	RXRB	Retinoid X receptor beta. (453 aa)
	TIFA	TRAF interacting protein with forkhead associated domain. (203 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	LACC1	Laccase (multicopper oxidoreductase) domain containing 1. (442 aa)
	NR2C2	Nuclear receptor subfamily 2 group C member 2. (605 aa)
	CLPB	ClpB homolog, mitochondrial AAA ATPase chaperonin. (425 aa)
	CALCOCO1	Calcium binding and coiled-coil domain 1. (707 aa)
	NR2F2	Nuclear receptor subfamily 2 group F member 2. (418 aa)
	TRERF1	Transcriptional regulating factor 1. (1190 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (403 aa)
	H3AM65_LATCH	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (472 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (614 aa)
	NR1I3	Nuclear receptor subfamily 1 group I member 3. (384 aa)
	ESRRG	Estrogen related receptor gamma. (268 aa)
	AHRR	PAS domain-containing protein. (653 aa)
	THRA	Thyroid hormone receptor alpha. (408 aa)
	NR1I2	Nuclear receptor subfamily 1 group I member 2. (428 aa)
	LOC102367296	Nuclear receptor subfamily 2, group F, member 5. (396 aa)
	NR4A2	Nuclear receptor subfamily 4 group A member 2. (599 aa)
	NR2F6	Nuclear receptor subfamily 2 group F member 6. (390 aa)
	INAVA	Innate immunity activator. (599 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	DHX58	DExH-box helicase 58. (680 aa)
	PPARGC1B	PPARG coactivator 1 beta. (986 aa)
	IFIH1	Interferon induced with helicase C domain 1. (731 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1401 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	UBR5	Ubiquitin protein ligase E3 component n-recognin 5. (2787 aa)
	H3AXK3_LATCH	BHLH domain-containing protein. (73 aa)
	LOC102346373	Uncharacterized protein. (464 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (219 aa)
	SNW1	SNW domain containing 1. (536 aa)
	PTF1A	Pancreas associated transcription factor 1a. (266 aa)
	HNF4A	Hepatocyte nuclear factor 4 alpha. (465 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (907 aa)
	TMF1	TATA element modulatory factor 1. (1135 aa)
	LOC102345440	Nuclear receptor subfamily 1, group D, member 4b. (554 aa)
	AR	Androgen receptor. (412 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (512 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (426 aa)
	CYP26B1	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa)
	ESRRB	Estrogen related receptor beta. (174 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (770 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (477 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (396 aa)
	RARG	Retinoic acid receptor gamma. (389 aa)
	NR2F1	Nuclear receptor subfamily 2 group F member 1. (435 aa)
	RORA	RAR related orphan receptor A. (468 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (456 aa)
	NFKBIA	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (298 aa)
	RORC	RAR related orphan receptor C. (502 aa)
	ESRRA	Estrogen-related receptor gamma b. (416 aa)
	LOC102361847	Uncharacterized protein. (517 aa)
	RNF34	Ring finger protein 34. (384 aa)
	NR5A1	Nuclear receptor subfamily 5 group A member 1. (196 aa)
	H3BH94_LATCH	PAS domain-containing protein. (733 aa)
	RXRA	Retinoid X receptor alpha. (363 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (375 aa)
	NR4A1	Nuclear receptor subfamily 4 group A member 1. (580 aa)
	NR2E3	Nuclear receptor subfamily 2 group E member 3. (408 aa)
	PGR	Progesterone receptor. (770 aa)
	ESR2	Estrogen receptor 2. (583 aa)
	LOC102351060	Uncharacterized protein. (459 aa)
	VDR	Vitamin D receptor. (427 aa)
	M3XKI0_LATCH	Nuclear receptor domain-containing protein. (49 aa)
	NR6A1	Nuclear receptor subfamily 6 group A member 1. (444 aa)
	LOC102348796	Uncharacterized protein. (497 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALPK1	LOC102348796	ENSLACP00000005110	ENSLACP00000023619	Alpha kinase 1.	Uncharacterized protein.	0.505
ALPK1	RIPK2	ENSLACP00000005110	ENSLACP00000004499	Alpha kinase 1.	Receptor interacting serine/threonine kinase 2.	0.599
ALPK1	TIFA	ENSLACP00000005110	ENSLACP00000008014	Alpha kinase 1.	TRAF interacting protein with forkhead associated domain.	0.873
AR	DAXX	ENSLACP00000017054	ENSLACP00000001216	Androgen receptor.	Death-domain associated protein.	0.509
AR	ESR2	ENSLACP00000017054	ENSLACP00000022358	Androgen receptor.	Estrogen receptor 2.	0.615
AR	H3AM65_LATCH	ENSLACP00000017054	ENSLACP00000010736	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.569
AR	MED1	ENSLACP00000017054	ENSLACP00000013232	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.569
AR	NR3C1	ENSLACP00000017054	ENSLACP00000017638	Androgen receptor.	Nuclear receptor subfamily 3 group C member 1.	0.673
AR	NR5A1	ENSLACP00000017054	ENSLACP00000021263	Androgen receptor.	Nuclear receptor subfamily 5 group A member 1.	0.427
AR	PGR	ENSLACP00000017054	ENSLACP00000022009	Androgen receptor.	Progesterone receptor.	0.697
AR	STAT3	ENSLACP00000017054	ENSLACP00000013656	Androgen receptor.	Signal transducer and activator of transcription.	0.595
CLPB	PDK3	ENSLACP00000009565	ENSLACP00000007419	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Protein-serine/threonine kinase.	0.435
CLPB	PHB	ENSLACP00000009565	ENSLACP00000006862	ClpB homolog, mitochondrial AAA ATPase chaperonin.	Prohibitin.	0.411
CRKL	LOC102364341	ENSLACP00000014901	ENSLACP00000001390	CRK like proto-oncogene, adaptor protein.	Uncharacterized protein.	0.902
CYP26B1	CYP7B1	ENSLACP00000017241	ENSLACP00000005456	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.	0.633
CYP26B1	RARB	ENSLACP00000017241	ENSLACP00000007216	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	NR LBD domain-containing protein.	0.438
CYP7B1	CYP26B1	ENSLACP00000005456	ENSLACP00000017241	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	0.633
CYP7B1	LOC102361847	ENSLACP00000005456	ENSLACP00000021031	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.445
CYP7B1	NR1H4	ENSLACP00000005456	ENSLACP00000020088	Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family.	Nuclear receptor subfamily 1 group H member 4.	0.572
DAXX	AR	ENSLACP00000001216	ENSLACP00000017054	Death-domain associated protein.	Androgen receptor.	0.509