(37 nodes) Endocytic vesicle membrane network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H3ACA4_LATCH	Ig-like domain-containing protein. (156 aa)
	RAB22A	RAB22A, member RAS oncogene family. (194 aa)
	RAB31	RAB31, member RAS oncogene family. (195 aa)
	PIP4P1	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (289 aa)
	LOC102352152	Uncharacterized protein. (206 aa)
	INPP5B	Inositol polyphosphate-5-phosphatase B. (1012 aa)
	OCRL	OCRL inositol polyphosphate-5-phosphatase. (815 aa)
	SYT7	Synaptotagmin 7. (286 aa)
	TLR6	Toll like receptor 6; Belongs to the Toll-like receptor family. (793 aa)
	LOC102360588	Uncharacterized protein. (214 aa)
	AP2S1	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (142 aa)
	TLR2	Toll like receptor 2; Belongs to the Toll-like receptor family. (798 aa)
	SLC18A3	Solute carrier family 18 member A3. (530 aa)
	RAB38-2	RAB38b, member of RAS oncogene family. (79 aa)
	SGIP1	SH3 domain GRB2 like endophilin interacting protein 1; Belongs to the adaptor complexes medium subunit family. (644 aa)
	RAB11FIP1	RAB11 family interacting protein 1. (1225 aa)
	PIKFYVE	Phosphoinositide kinase, FYVE-type zinc finger containing. (2113 aa)
	AP2M1	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (434 aa)
	RAB7B	RAB7B, member RAS oncogene family. (201 aa)
	LOC102350366	TIR domain-containing protein. (789 aa)
	RAB7A	RAB7A, member RAS oncogene family. (207 aa)
	AP2A1	Alpha_adaptinC2 domain-containing protein. (737 aa)
	LOC102355189	Toll-like receptor 18; Belongs to the Toll-like receptor family. (797 aa)
	RAB9B	RAB9B, member RAS oncogene family. (213 aa)
	RILP	Rab interacting lysosomal protein. (423 aa)
	RAB32	Uncharacterized protein. (174 aa)
	VAMP7	Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (220 aa)
	LAMP1	Lysosomal associated membrane protein 1. (412 aa)
	LAMP2	Lysosomal associated membrane protein 2. (416 aa)
	LOC102363116	TIR domain-containing protein. (141 aa)
	SCARB2	Scavenger receptor class B member 2; Belongs to the CD36 family. (375 aa)
	PIP4P2	Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
	TYRP1	Tyrosinase related protein 1. (536 aa)
	LOC102357859	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (992 aa)
	ANXA3	Annexin. (323 aa)
	RAB38	RAB38b, member of RAS oncogene family. (112 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (484 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP2A1	AP2M1	ENSLACP00000019999	ENSLACP00000015716	Alpha_adaptinC2 domain-containing protein.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.999
AP2A1	AP2S1	ENSLACP00000019999	ENSLACP00000014068	Alpha_adaptinC2 domain-containing protein.	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.999
AP2A1	APPL2	ENSLACP00000019999	ENSLACP00000000307	Alpha_adaptinC2 domain-containing protein.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.413
AP2A1	LOC102357859	ENSLACP00000019999	ENSLACP00000001698	Alpha_adaptinC2 domain-containing protein.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.660
AP2A1	OCRL	ENSLACP00000019999	ENSLACP00000010968	Alpha_adaptinC2 domain-containing protein.	OCRL inositol polyphosphate-5-phosphatase.	0.413
AP2A1	SGIP1	ENSLACP00000019999	ENSLACP00000014967	Alpha_adaptinC2 domain-containing protein.	SH3 domain GRB2 like endophilin interacting protein 1; Belongs to the adaptor complexes medium subunit family.	0.713
AP2A1	VAMP7	ENSLACP00000019999	ENSLACP00000007050	Alpha_adaptinC2 domain-containing protein.	Vesicle associated membrane protein 7; Belongs to the synaptobrevin family.	0.671
AP2M1	AP2A1	ENSLACP00000015716	ENSLACP00000019999	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Alpha_adaptinC2 domain-containing protein.	0.999
AP2M1	AP2S1	ENSLACP00000015716	ENSLACP00000014068	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	0.999
AP2M1	APPL2	ENSLACP00000015716	ENSLACP00000000307	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.480
AP2M1	LOC102357859	ENSLACP00000015716	ENSLACP00000001698	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.998
AP2M1	SGIP1	ENSLACP00000015716	ENSLACP00000014967	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	SH3 domain GRB2 like endophilin interacting protein 1; Belongs to the adaptor complexes medium subunit family.	0.831
AP2M1	VAMP7	ENSLACP00000015716	ENSLACP00000007050	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	Vesicle associated membrane protein 7; Belongs to the synaptobrevin family.	0.670
AP2S1	AP2A1	ENSLACP00000014068	ENSLACP00000019999	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Alpha_adaptinC2 domain-containing protein.	0.999
AP2S1	AP2M1	ENSLACP00000014068	ENSLACP00000015716	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]	0.999
AP2S1	APPL2	ENSLACP00000014068	ENSLACP00000000307	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.441
AP2S1	LOC102357859	ENSLACP00000014068	ENSLACP00000001698	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]	0.998
AP2S1	SGIP1	ENSLACP00000014068	ENSLACP00000014967	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	SH3 domain GRB2 like endophilin interacting protein 1; Belongs to the adaptor complexes medium subunit family.	0.828
AP2S1	VAMP7	ENSLACP00000014068	ENSLACP00000007050	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.	Vesicle associated membrane protein 7; Belongs to the synaptobrevin family.	0.684
APPL2	AP2A1	ENSLACP00000000307	ENSLACP00000019999	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Alpha_adaptinC2 domain-containing protein.	0.413