(37 nodes) Negative regulation of actin filament depolymerization network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SCIN	Scinderin. (632 aa)
	VIL1	Villin 1. (832 aa)
	ADD3	Adducin 3. (702 aa)
	CAPZA3	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (285 aa)
	CAPG	Capping actin protein, gelsolin like. (349 aa)
	TMOD3	Tropomodulin 3. (352 aa)
	LOC102351334	Scinderin like a. (721 aa)
	LOC102360693	FERM domain-containing protein. (560 aa)
	LOC102367195	HP domain-containing protein. (741 aa)
	FLII	FLII actin remodeling protein. (1259 aa)
	CAPZB	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (277 aa)
	LIMA1	LIM domain and actin binding 1. (545 aa)
	GSN	Gelsolin. (757 aa)
	H3ASN6_LATCH	HP domain-containing protein. (111 aa)
	LMOD1	Leiomodin 1. (603 aa)
	LOC102351332	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1067 aa)
	TMOD4	Tropomodulin 4. (353 aa)
	LMOD2	Leiomodin 2. (544 aa)
	ADD1	Adducin 1. (805 aa)
	SPTBN1	Spectrin beta chain; Belongs to the spectrin family. (2278 aa)
	SPTAN1	Spectrin alpha, non-erythrocytic 1. (2494 aa)
	LMOD3	Leiomodin 3. (551 aa)
	TMOD1	Tropomodulin 1. (361 aa)
	CAPZA2	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
	PLEKHH2	Pleckstrin homology, MyTH4 and FERM domain containing H2. (1509 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	DEF6	DEF6 guanine nucleotide exchange factor. (624 aa)
	TWF1	Twinfilin actin binding protein 1. (351 aa)
	SVIL	Supervillin. (2196 aa)
	DMTN	Dematin actin binding protein. (406 aa)
	SPTB	Spectrin beta chain; Belongs to the spectrin family. (2351 aa)
	ADD2	Adducin 2. (742 aa)
	H3BDJ8_LATCH	Spectrin beta chain; Belongs to the spectrin family. (2316 aa)
	SPTBN5	Spectrin beta, non-erythrocytic 5. (3576 aa)
	CAPZA1	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (292 aa)
	AVIL	Advillin. (873 aa)
	SPTBN2	Spectrin beta chain; Belongs to the spectrin family. (2288 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADD1	ADD2	ENSLACP00000014663	ENSLACP00000019654	Adducin 1.	Adducin 2.	0.979
ADD1	ADD3	ENSLACP00000014663	ENSLACP00000001781	Adducin 1.	Adducin 3.	0.968
ADD1	CAPZB	ENSLACP00000014663	ENSLACP00000008482	Adducin 1.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.508
ADD1	DMTN	ENSLACP00000014663	ENSLACP00000019018	Adducin 1.	Dematin actin binding protein.	0.877
ADD1	TMOD1	ENSLACP00000014663	ENSLACP00000016388	Adducin 1.	Tropomodulin 1.	0.465
ADD1	TMOD3	ENSLACP00000014663	ENSLACP00000005031	Adducin 1.	Tropomodulin 3.	0.517
ADD1	TMOD4	ENSLACP00000014663	ENSLACP00000013837	Adducin 1.	Tropomodulin 4.	0.465
ADD2	ADD1	ENSLACP00000019654	ENSLACP00000014663	Adducin 2.	Adducin 1.	0.979
ADD2	CAPZB	ENSLACP00000019654	ENSLACP00000008482	Adducin 2.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.491
ADD2	DMTN	ENSLACP00000019654	ENSLACP00000019018	Adducin 2.	Dematin actin binding protein.	0.885
ADD2	TMOD1	ENSLACP00000019654	ENSLACP00000016388	Adducin 2.	Tropomodulin 1.	0.455
ADD2	TMOD3	ENSLACP00000019654	ENSLACP00000005031	Adducin 2.	Tropomodulin 3.	0.529
ADD2	TMOD4	ENSLACP00000019654	ENSLACP00000013837	Adducin 2.	Tropomodulin 4.	0.455
ADD3	ADD1	ENSLACP00000001781	ENSLACP00000014663	Adducin 3.	Adducin 1.	0.968
ADD3	CAPZB	ENSLACP00000001781	ENSLACP00000008482	Adducin 3.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.491
ADD3	DMTN	ENSLACP00000001781	ENSLACP00000019018	Adducin 3.	Dematin actin binding protein.	0.877
ADD3	TMOD1	ENSLACP00000001781	ENSLACP00000016388	Adducin 3.	Tropomodulin 1.	0.456
ADD3	TMOD3	ENSLACP00000001781	ENSLACP00000005031	Adducin 3.	Tropomodulin 3.	0.510
ADD3	TMOD4	ENSLACP00000001781	ENSLACP00000013837	Adducin 3.	Tropomodulin 4.	0.456
AVIL	TWF1	ENSLACP00000020633	ENSLACP00000018579	Advillin.	Twinfilin actin binding protein 1.	0.491