(48 nodes) Negative regulation of actin filament polymerization network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

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protein homology

Your Input:
	GSN	Gelsolin. (757 aa)
	LOC102350832	Zgc:77748. (293 aa)
	ADD3	Adducin 3. (702 aa)
	SLIT2	Slit guidance ligand 2. (1372 aa)
	H3ASN6_LATCH	HP domain-containing protein. (111 aa)
	LMOD1	Leiomodin 1. (603 aa)
	TMOD4	Tropomodulin 4. (353 aa)
	LMOD2	Leiomodin 2. (544 aa)
	ADD1	Adducin 1. (805 aa)
	SPTBN1	Spectrin beta chain; Belongs to the spectrin family. (2278 aa)
	SPTAN1	Spectrin alpha, non-erythrocytic 1. (2494 aa)
	LMOD3	Leiomodin 3. (551 aa)
	TMOD1	Tropomodulin 1. (361 aa)
	CAPZA2	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
	SSH2	Slingshot protein phosphatase 2. (1443 aa)
	TWF1	Twinfilin actin binding protein 1. (351 aa)
	SVIL	Supervillin. (2196 aa)
	DMTN	Dematin actin binding protein. (406 aa)
	BBS4	Bardet-Biedl syndrome 4. (537 aa)
	MYADM	Myeloid associated differentiation marker. (314 aa)
	CAPZA3	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (285 aa)
	CAPG	Capping actin protein, gelsolin like. (349 aa)
	SSH1	Slingshot protein phosphatase 1. (1000 aa)
	TMOD3	Tropomodulin 3. (352 aa)
	LOC102351334	Scinderin like a. (721 aa)
	MKKS	McKusick-Kaufman syndrome. (575 aa)
	LOC102360693	FERM domain-containing protein. (560 aa)
	LOC102367195	HP domain-containing protein. (741 aa)
	H3AC70_LATCH	LRRNT domain-containing protein. (132 aa)
	FLII	FLII actin remodeling protein. (1259 aa)
	CAPZB	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (277 aa)
	ARFGEF1	ADP ribosylation factor guanine nucleotide exchange factor 1. (1801 aa)
	KANK4	KN motif and ankyrin repeat domains 4. (994 aa)
	FAM49B	Family with sequence similarity 49 member B. (324 aa)
	SSH3	Uncharacterized protein. (590 aa)
	SPTB	Spectrin beta chain; Belongs to the spectrin family. (2351 aa)
	H3BCE9_LATCH	KN motif and ankyrin repeat domains 3. (1268 aa)
	ADD2	Adducin 2. (742 aa)
	H3BDJ8_LATCH	Spectrin beta chain; Belongs to the spectrin family. (2316 aa)
	HIP1R	Huntingtin interacting protein 1 related. (1039 aa)
	SPTBN5	Spectrin beta, non-erythrocytic 5. (3576 aa)
	CAPZA1	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (292 aa)
	AVIL	Advillin. (873 aa)
	SPTBN2	Spectrin beta chain; Belongs to the spectrin family. (2288 aa)
	PFN4	Profilin; Belongs to the profilin family. (128 aa)
	KANK1	KN motif and ankyrin repeat domains 1. (1193 aa)
	SCIN	Scinderin. (632 aa)
	VIL1	Villin 1. (832 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADD1	ADD2	ENSLACP00000014663	ENSLACP00000019654	Adducin 1.	Adducin 2.	0.979
ADD1	ADD3	ENSLACP00000014663	ENSLACP00000001781	Adducin 1.	Adducin 3.	0.968
ADD1	CAPZB	ENSLACP00000014663	ENSLACP00000008482	Adducin 1.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.508
ADD1	DMTN	ENSLACP00000014663	ENSLACP00000019018	Adducin 1.	Dematin actin binding protein.	0.877
ADD1	TMOD1	ENSLACP00000014663	ENSLACP00000016388	Adducin 1.	Tropomodulin 1.	0.465
ADD1	TMOD3	ENSLACP00000014663	ENSLACP00000005031	Adducin 1.	Tropomodulin 3.	0.517
ADD1	TMOD4	ENSLACP00000014663	ENSLACP00000013837	Adducin 1.	Tropomodulin 4.	0.465
ADD2	ADD1	ENSLACP00000019654	ENSLACP00000014663	Adducin 2.	Adducin 1.	0.979
ADD2	CAPZB	ENSLACP00000019654	ENSLACP00000008482	Adducin 2.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.491
ADD2	DMTN	ENSLACP00000019654	ENSLACP00000019018	Adducin 2.	Dematin actin binding protein.	0.885
ADD2	TMOD1	ENSLACP00000019654	ENSLACP00000016388	Adducin 2.	Tropomodulin 1.	0.455
ADD2	TMOD3	ENSLACP00000019654	ENSLACP00000005031	Adducin 2.	Tropomodulin 3.	0.529
ADD2	TMOD4	ENSLACP00000019654	ENSLACP00000013837	Adducin 2.	Tropomodulin 4.	0.455
ADD3	ADD1	ENSLACP00000001781	ENSLACP00000014663	Adducin 3.	Adducin 1.	0.968
ADD3	CAPZB	ENSLACP00000001781	ENSLACP00000008482	Adducin 3.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.491
ADD3	DMTN	ENSLACP00000001781	ENSLACP00000019018	Adducin 3.	Dematin actin binding protein.	0.877
ADD3	TMOD1	ENSLACP00000001781	ENSLACP00000016388	Adducin 3.	Tropomodulin 1.	0.456
ADD3	TMOD3	ENSLACP00000001781	ENSLACP00000005031	Adducin 3.	Tropomodulin 3.	0.510
ADD3	TMOD4	ENSLACP00000001781	ENSLACP00000013837	Adducin 3.	Tropomodulin 4.	0.456
AVIL	TWF1	ENSLACP00000020633	ENSLACP00000018579	Advillin.	Twinfilin actin binding protein 1.	0.491