(77 nodes) Hindbrain development network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EN1	Homeobox protein engrailed-like. (271 aa)
	BMP7	Bone morphogenetic protein 7. (425 aa)
	HNF1A	HNF1 homeobox A. (624 aa)
	LHX1	LIM homeobox 1. (406 aa)
	HSPA5	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
	MDK	Midkine. (141 aa)
	DIXDC1	DIX domain containing 1. (695 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
	GLI1	GLI family zinc finger 1. (1380 aa)
	TTLL1	Tubulin tyrosine ligase like 1. (423 aa)
	RPGRIP1L	RPGRIP1 like. (1318 aa)
	SEZ6L	Seizure related 6 homolog like. (776 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (1197 aa)
	H3AC16_LATCH	X-ray repair complementing defective repair in Chinese hamster cells 1. (649 aa)
	NAGLU	N-acetyl-alpha-glucosaminidase. (614 aa)
	ABL2	Tyrosine-protein kinase. (1175 aa)
	AGTPBP1	ATP/GTP binding protein 1. (1243 aa)
	GBX2	Gastrulation brain homeobox 2. (344 aa)
	LOC102359111	Nanos homolog 1; Belongs to the nanos family. (224 aa)
	LEF1	Lymphoid enhancer binding factor 1. (397 aa)
	AARS1	Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. (968 aa)
	PHOX2B	Paired like homeobox 2B. (287 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (403 aa)
	SEZ6L2	Seizure related 6 homolog like 2. (870 aa)
	LHX5	LIM homeobox 5. (402 aa)
	H3A478_LATCH	PDZ domain-containing protein. (297 aa)
	TTC21B	Tetratricopeptide repeat domain 21B. (1311 aa)
	TBR1	T-box brain transcription factor 1. (673 aa)
	KLHL5	Kelch like family member 5. (751 aa)
	CNTN1	Contactin 1. (1009 aa)
	CLP1	Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (424 aa)
	H3A0S5_LATCH	Uncharacterized protein. (547 aa)
	KLHL4	Kelch like family member 4. (590 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
	FZD4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (530 aa)
	PTBP2	Polypyrimidine tract binding protein 2. (535 aa)
	EN2	Homeobox protein engrailed-like. (262 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	LOC102364341	Uncharacterized protein. (271 aa)
	TTBK2	Tau tubulin kinase 2. (1233 aa)
	DLL3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
	PHOX2A	Paired like homeobox 2A. (285 aa)
	ARL13B	ADP ribosylation factor like GTPase 13B. (343 aa)
	LRRC1	Uncharacterized protein. (155 aa)
	GAS1	Growth arrest specific 1. (259 aa)
	H3AIG1_LATCH	Uncharacterized protein. (317 aa)
	CDK5	Cyclin dependent kinase 5. (290 aa)
	UQCRQ	Ubiquinol-cytochrome c reductase complex III subunit VII. (82 aa)
	ATF5	Activating transcription factor 5. (340 aa)
	PDSS2	Decaprenyl diphosphate synthase subunit 2; Belongs to the FPP/GGPP synthase family. (384 aa)
	LOC102345793	Si:dkeyp-92c9.2. (294 aa)
	KIF14	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1644 aa)
	H3ALU1_LATCH	Uncharacterized protein. (1358 aa)
	NCSTN	Nicastrin. (680 aa)
	GSX2	GS homeobox 2. (279 aa)
	H3APE8_LATCH	Uncharacterized protein. (135 aa)
	KNDC1	Uncharacterized protein. (1728 aa)
	CRK	CRK proto-oncogene, adaptor protein. (310 aa)
	CDK5R1	Cyclin-dependent kinase 5 activator. (306 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	MECP2	Methyl-CpG binding protein 2. (459 aa)
	KLHL1	Kelch like family member 1. (411 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (219 aa)
	PTF1A	Pancreas associated transcription factor 1a. (266 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
	KCNE1	Uncharacterized protein. (122 aa)
	HOXB1	Homeobox B1. (309 aa)
	HOXB2	Homeobox B2. (362 aa)
	HOXB3	Homeobox B3. (404 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	NANOS1	Nanos C2HC-type zinc finger 1; Belongs to the nanos family. (213 aa)
	ABL1	Tyrosine-protein kinase. (1156 aa)
	GNPAT	Glyceronephosphate O-acyltransferase; Belongs to the GPAT/DAPAT family. (686 aa)
	H3B9R0_LATCH	Uncharacterized protein. (128 aa)
	CDK5R2	Cyclin-dependent kinase 5 activator. (325 aa)
	OTX1	Orthodenticle homeobox 1. (339 aa)
	HOXA2	Homeobox A2b. (366 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ABL2	ENSLACP00000017765	ENSLACP00000006377	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
ABL1	CDK5	ENSLACP00000017765	ENSLACP00000009607	Tyrosine-protein kinase.	Cyclin dependent kinase 5.	0.495
ABL1	CRK	ENSLACP00000017765	ENSLACP00000011971	Tyrosine-protein kinase.	CRK proto-oncogene, adaptor protein.	0.853
ABL1	CRKL	ENSLACP00000017765	ENSLACP00000014901	Tyrosine-protein kinase.	CRK like proto-oncogene, adaptor protein.	0.961
ABL1	CTNNB1	ENSLACP00000017765	ENSLACP00000017209	Tyrosine-protein kinase.	Catenin beta 1.	0.684
ABL1	LOC102364341	ENSLACP00000017765	ENSLACP00000001390	Tyrosine-protein kinase.	Uncharacterized protein.	0.961
ABL1	TP53	ENSLACP00000017765	ENSLACP00000015915	Tyrosine-protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.448
ABL2	ABL1	ENSLACP00000006377	ENSLACP00000017765	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
ABL2	CDK5	ENSLACP00000006377	ENSLACP00000009607	Tyrosine-protein kinase.	Cyclin dependent kinase 5.	0.495
ABL2	CRK	ENSLACP00000006377	ENSLACP00000011971	Tyrosine-protein kinase.	CRK proto-oncogene, adaptor protein.	0.853
ABL2	CRKL	ENSLACP00000006377	ENSLACP00000014901	Tyrosine-protein kinase.	CRK like proto-oncogene, adaptor protein.	0.961
ABL2	CTNNB1	ENSLACP00000006377	ENSLACP00000017209	Tyrosine-protein kinase.	Catenin beta 1.	0.684
ABL2	LOC102364341	ENSLACP00000006377	ENSLACP00000001390	Tyrosine-protein kinase.	Uncharacterized protein.	0.961
ABL2	TP53	ENSLACP00000006377	ENSLACP00000015915	Tyrosine-protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.448
ARL13B	GLI1	ENSLACP00000008225	ENSLACP00000021691	ADP ribosylation factor like GTPase 13B.	GLI family zinc finger 1.	0.420
ARL13B	H3A0S5_LATCH	ENSLACP00000008225	ENSLACP00000003246	ADP ribosylation factor like GTPase 13B.	Uncharacterized protein.	0.624
ARL13B	RPGRIP1L	ENSLACP00000008225	ENSLACP00000022895	ADP ribosylation factor like GTPase 13B.	RPGRIP1 like.	0.592
ARL13B	SMO	ENSLACP00000008225	ENSLACP00000002758	ADP ribosylation factor like GTPase 13B.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.623
ATF5	HSPA5	ENSLACP00000009869	ENSLACP00000020775	Activating transcription factor 5.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.425
BMP7	SMAD1	ENSLACP00000019986	ENSLACP00000012771	Bone morphogenetic protein 7.	Mothers against decapentaplegic homolog.	0.516