(27 nodes) Pancreas development network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2ZVQ7_LATCH	Peptidase_S8 domain-containing protein. (135 aa)
	DNAAF1	Dynein assembly factor 1, axonemal. (263 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
	GATA6	GATA binding protein 6. (503 aa)
	NKX3-2	NK3 homeobox 2. (282 aa)
	RFX6	Regulatory factor X6. (929 aa)
	IGF2	Insulin like growth factor 2. (207 aa)
	NKX6-2	NK6 homeobox 2. (278 aa)
	PCSK1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (662 aa)
	DLL3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	LOC102346566	Annexin. (343 aa)
	SELENOT	Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (137 aa)
	NKX6-1	NK6 homeobox 1. (316 aa)
	BMP6	Bone morphogenetic protein 6. (428 aa)
	WFS1	Wolframin ER transmembrane glycoprotein. (876 aa)
	MNX1	Motor neuron and pancreas homeobox 1. (313 aa)
	PTF1A	Pancreas associated transcription factor 1a. (266 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	PAX6	Paired box 6. (463 aa)
	BAK1	BCL2 antagonist/killer 1. (239 aa)
	PDX1	Pancreatic and duodenal homeobox 1. (257 aa)
	CCDC40	Coiled-coil domain containing 40. (859 aa)
	SRP54	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
	HNF1A	HNF1 homeobox A. (624 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (958 aa)
	IL6R	Interleukin 6 receptor. (469 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC40	DNAAF1	ENSLACP00000020296	ENSLACP00000002439	Coiled-coil domain containing 40.	Dynein assembly factor 1, axonemal.	0.571
CTNNB1	SMO	ENSLACP00000017209	ENSLACP00000002758	Catenin beta 1.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.483
DLL1	DLL3	ENSLACP00000009351	ENSLACP00000008690	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL3	DLL1	ENSLACP00000008690	ENSLACP00000009351	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DNAAF1	CCDC40	ENSLACP00000002439	ENSLACP00000020296	Dynein assembly factor 1, axonemal.	Coiled-coil domain containing 40.	0.571
EIF2AK3	WFS1	ENSLACP00000022169	ENSLACP00000013099	Eukaryotic translation initiation factor 2 alpha kinase 3.	Wolframin ER transmembrane glycoprotein.	0.418
GATA6	PTF1A	ENSLACP00000002849	ENSLACP00000015592	GATA binding protein 6.	Pancreas associated transcription factor 1a.	0.503
HNF1A	PDX1	ENSLACP00000020387	ENSLACP00000018877	HNF1 homeobox A.	Pancreatic and duodenal homeobox 1.	0.455
HNF1A	PTF1A	ENSLACP00000020387	ENSLACP00000015592	HNF1 homeobox A.	Pancreas associated transcription factor 1a.	0.535
MNX1	PCSK1	ENSLACP00000014098	ENSLACP00000008352	Motor neuron and pancreas homeobox 1.	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	0.425
MNX1	PTF1A	ENSLACP00000014098	ENSLACP00000015592	Motor neuron and pancreas homeobox 1.	Pancreas associated transcription factor 1a.	0.451
MNX1	RFX6	ENSLACP00000014098	ENSLACP00000004542	Motor neuron and pancreas homeobox 1.	Regulatory factor X6.	0.575
NKX6-1	PDX1	ENSLACP00000012246	ENSLACP00000018877	NK6 homeobox 1.	Pancreatic and duodenal homeobox 1.	0.426
NKX6-1	PTF1A	ENSLACP00000012246	ENSLACP00000015592	NK6 homeobox 1.	Pancreas associated transcription factor 1a.	0.418
NKX6-2	PTF1A	ENSLACP00000008144	ENSLACP00000015592	NK6 homeobox 2.	Pancreas associated transcription factor 1a.	0.418
PAX6	PDX1	ENSLACP00000017411	ENSLACP00000018877	Paired box 6.	Pancreatic and duodenal homeobox 1.	0.629
PAX6	PTF1A	ENSLACP00000017411	ENSLACP00000015592	Paired box 6.	Pancreas associated transcription factor 1a.	0.495
PAX6	RFX6	ENSLACP00000017411	ENSLACP00000004542	Paired box 6.	Regulatory factor X6.	0.404
PAX6	SMO	ENSLACP00000017411	ENSLACP00000002758	Paired box 6.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.469
PCSK1	MNX1	ENSLACP00000008352	ENSLACP00000014098	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family.	Motor neuron and pancreas homeobox 1.	0.425