(113 nodes) Leading edge membrane network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102349512	Uncharacterized protein. (524 aa)
	LOC102352818	PH domain-containing protein. (249 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (484 aa)
	KCNC2	Ion_trans domain-containing protein; Belongs to the potassium channel family. (322 aa)
	ITGAV	Integrin_alpha2 domain-containing protein. (597 aa)
	H2ZTT6_LATCH	Phosphoinositide phospholipase C. (404 aa)
	C2CD5	C2 calcium dependent domain containing 5. (581 aa)
	H2ZU85_LATCH	DUF659 domain-containing protein. (137 aa)
	LOC102346417	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (604 aa)
	LOC102367488	Uncharacterized protein. (178 aa)
	SHISA7	Shisa family member 7. (469 aa)
	H2ZWE3_LATCH	Uncharacterized protein. (222 aa)
	SH3YL1	SH3 and SYLF domain containing 1. (341 aa)
	GABRA2	Gamma-aminobutyric acid type A receptor alpha2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (380 aa)
	H2ZWN0_LATCH	Reverse transcriptase domain-containing protein. (142 aa)
	H2ZXG6_LATCH	Uncharacterized protein. (135 aa)
	H2ZXP3_LATCH	Uncharacterized protein. (173 aa)
	GABRA4	Gamma-aminobutyric acid type A receptor alpha4 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (562 aa)
	AIF1	Allograft inflammatory factor 1. (119 aa)
	UNC5A	Unc-5 netrin receptor A. (798 aa)
	SHISA9	Uncharacterized protein. (172 aa)
	H3A1D7_LATCH	Uncharacterized protein. (157 aa)
	GABRA5	Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (454 aa)
	LOC102352804	Phosphoinositide phospholipase C. (1172 aa)
	H3A2S1_LATCH	BTB domain-containing protein. (180 aa)
	H3A3T3_LATCH	Uncharacterized protein. (219 aa)
	ATF4	Activating transcription factor 4. (374 aa)
	DDRGK1-2	DUF659 domain-containing protein. (142 aa)
	GABRG3	Gamma-aminobutyric acid type A receptor gamma3 subunit. (223 aa)
	H3A4S8_LATCH	Uncharacterized protein. (2030 aa)
	H3A551_LATCH	Phosphodiesterase. (437 aa)
	PLA2G4F	Phospholipase A2. (785 aa)
	DOCK8	Dedicator of cytokinesis 8; Belongs to the DOCK family. (2039 aa)
	EPS8	Epidermal growth factor receptor pathway substrate 8. (774 aa)
	H3A6W7_LATCH	C2 domain-containing protein. (310 aa)
	APC	APC regulator of WNT signaling pathway. (2802 aa)
	CLASP2	Cytoplasmic linker associated protein 2. (1303 aa)
	H3A900_LATCH	Uncharacterized protein. (166 aa)
	H3AA55_LATCH	Uncharacterized protein. (329 aa)
	H3AAA0_LATCH	Uncharacterized protein. (136 aa)
	EZR	Ezrin. (591 aa)
	LAMP5	Lysosomal associated membrane protein family member 5. (280 aa)
	RPS3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (254 aa)
	H3ABA6_LATCH	Uncharacterized protein. (147 aa)
	JCAD	Junctional cadherin 5 associated. (1240 aa)
	RIPOR2	RHO family interacting cell polarization regulator 2. (1059 aa)
	H3ADH6_LATCH	DUF659 domain-containing protein. (143 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (476 aa)
	EPS8L3	EPS8 like 3. (526 aa)
	PTPRK	Protein tyrosine phosphatase receptor type K. (565 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	SLC39A6	Solute carrier family 39 member 6. (742 aa)
	ARHGEF2	Rho/Rac guanine nucleotide exchange factor 2. (1027 aa)
	PIP5K1A	Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (878 aa)
	H3AG43_LATCH	Uncharacterized protein. (169 aa)
	H3AH58_LATCH	Uncharacterized protein. (107 aa)
	MYO6	Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1230 aa)
	ATP6AP2	ATPase H+ transporting accessory protein 2. (367 aa)
	H3AI98_LATCH	Uncharacterized protein. (216 aa)
	APC2	APC regulator of WNT signaling pathway 2. (2366 aa)
	H3AJX7_LATCH	DUF659 domain-containing protein. (143 aa)
	H3AL67_LATCH	Uncharacterized protein. (121 aa)
	H3AM01_LATCH	Integrin beta; Belongs to the integrin beta chain family. (769 aa)
	MYO1C	Myosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1036 aa)
	H3ANL8_LATCH	Fibroblast activation protein, alpha; Belongs to the peptidase S9B family. (755 aa)
	GABRA3	Gamma-aminobutyric acid type A receptor alpha3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (398 aa)
	PDE9A	Phosphodiesterase. (519 aa)
	H3AR58_LATCH	Uncharacterized protein. (132 aa)
	MTMR9	Myotubularin related protein 9. (554 aa)
	LOC102350991	Uncharacterized protein. (1471 aa)
	MYO1D	Myosin ID; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (956 aa)
	FAM107A	Family with sequence similarity 107 member A. (150 aa)
	H3AUC6_LATCH	Link domain-containing protein. (405 aa)
	EPHA2	Uncharacterized protein. (979 aa)
	MTSS2	MTSS I-BAR domain containing 2. (674 aa)
	VASP	Vasodilator stimulated phosphoprotein. (444 aa)
	SLC1A2	Amino acid transporter. (566 aa)
	PSD2	Pleckstrin and Sec7 domain containing 2. (646 aa)
	SPRY4	Sprouty RTK signaling antagonist 4. (282 aa)
	PLEKHO1	Pleckstrin homology domain containing O1. (362 aa)
	LOC102363010	Si:ch211-51c14.1. (475 aa)
	SPATA13	Spermatogenesis associated 13. (559 aa)
	ARHGAP45	Rho GTPase activating protein 45. (1026 aa)
	KCNC1	Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family. (511 aa)
	H3B2B0_LATCH	SH3 domain-containing protein. (763 aa)
	GABRG2	Gamma-aminobutyric acid type A receptor gamma2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (476 aa)
	EPB41L5	Erythrocyte membrane protein band 4.1 like 5. (506 aa)
	H3B2J7_LATCH	Uncharacterized protein. (575 aa)
	PIP5K1C	Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (646 aa)
	LOC102358762	Amino acid transporter. (538 aa)
	LOC102360622	Phosphodiesterase. (504 aa)
	GABRA6	Gamma-aminobutyric acid type A receptor alpha6 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (544 aa)
	CDC42	Cell division cycle 42. (156 aa)
	DAGLA	Uncharacterized protein. (147 aa)
	H3B8L7_LATCH	Reverse transcriptase domain-containing protein. (526 aa)
	LOC102362769	Protein tyrosine phosphatase receptor type Jb, tandem duplicate 2. (358 aa)
	PLEK	Pleckstrin. (353 aa)
	PSD	Pleckstrin and Sec7 domain containing. (496 aa)
	CIB1	Calcium and integrin binding 1. (190 aa)
	KCNB1	Potassium voltage-gated channel, Shab-related subfamily, member 1; Belongs to the potassium channel family. (677 aa)
	GABRE	Gamma-aminobutyric acid type A receptor epsilon subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (450 aa)
	AIF1L	Allograft inflammatory factor 1 like. (148 aa)
	PACSIN1	Protein kinase C and casein kinase substrate in neurons 1. (490 aa)
	H3BCB5_LATCH	Uncharacterized protein. (307 aa)
	PACSIN2	Protein kinase C and casein kinase substrate in neurons 2. (330 aa)
	CIB3	Calcium and integrin binding family member 3. (209 aa)
	HIP1R	Huntingtin interacting protein 1 related. (1039 aa)
	TIRAP	TIR domain containing adaptor protein. (267 aa)
	KCNC4	Potassium voltage-gated channel subfamily C member 4; Belongs to the potassium channel family. (599 aa)
	GRIA1	Glutamate ionotropic receptor AMPA type subunit 1. (835 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1219 aa)
	LOC102355574	Potassium voltage-gated channel, Shaw-related subfamily, member 3b; Belongs to the potassium channel family. (609 aa)
	EPS8L2	EPS8 like 2. (761 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APC	H3B2J7_LATCH	ENSLACP00000005734	ENSLACP00000016118	APC regulator of WNT signaling pathway.	Uncharacterized protein.	0.458
APC	SPATA13	ENSLACP00000005734	ENSLACP00000015637	APC regulator of WNT signaling pathway.	Spermatogenesis associated 13.	0.458
APC2	H3B2J7_LATCH	ENSLACP00000009395	ENSLACP00000016118	APC regulator of WNT signaling pathway 2.	Uncharacterized protein.	0.458
APC2	SPATA13	ENSLACP00000009395	ENSLACP00000015637	APC regulator of WNT signaling pathway 2.	Spermatogenesis associated 13.	0.458
APPL2	PLEK	ENSLACP00000000307	ENSLACP00000018332	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Pleckstrin.	0.420
ARHGAP45	CDC42	ENSLACP00000015659	ENSLACP00000018010	Rho GTPase activating protein 45.	Cell division cycle 42.	0.623
ARHGEF2	CDC42	ENSLACP00000008231	ENSLACP00000018010	Rho/Rac guanine nucleotide exchange factor 2.	Cell division cycle 42.	0.667
C2CD5	H3A6W7_LATCH	ENSLACP00000000929	ENSLACP00000005388	C2 calcium dependent domain containing 5.	C2 domain-containing protein.	0.928
CDC42	ARHGAP45	ENSLACP00000018010	ENSLACP00000015659	Cell division cycle 42.	Rho GTPase activating protein 45.	0.623
CDC42	ARHGEF2	ENSLACP00000018010	ENSLACP00000008231	Cell division cycle 42.	Rho/Rac guanine nucleotide exchange factor 2.	0.667
CDC42	DOCK8	ENSLACP00000018010	ENSLACP00000004917	Cell division cycle 42.	Dedicator of cytokinesis 8; Belongs to the DOCK family.	0.976
CDC42	EPHA2	ENSLACP00000018010	ENSLACP00000013291	Cell division cycle 42.	Uncharacterized protein.	0.615
CDC42	EPS8	ENSLACP00000018010	ENSLACP00000005029	Cell division cycle 42.	Epidermal growth factor receptor pathway substrate 8.	0.476
CDC42	EZR	ENSLACP00000018010	ENSLACP00000006611	Cell division cycle 42.	Ezrin.	0.595
CDC42	H2ZTT6_LATCH	ENSLACP00000018010	ENSLACP00000000807	Cell division cycle 42.	Phosphoinositide phospholipase C.	0.458
CDC42	H3AUC6_LATCH	ENSLACP00000018010	ENSLACP00000013247	Cell division cycle 42.	Link domain-containing protein.	0.602
CDC42	H3B2J7_LATCH	ENSLACP00000018010	ENSLACP00000016118	Cell division cycle 42.	Uncharacterized protein.	0.740
CDC42	LOC102352804	ENSLACP00000018010	ENSLACP00000003859	Cell division cycle 42.	Phosphoinositide phospholipase C.	0.447
CDC42	MYO6	ENSLACP00000018010	ENSLACP00000009303	Cell division cycle 42.	Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.474
CDC42	PLCG1	ENSLACP00000018010	ENSLACP00000021632	Cell division cycle 42.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.458