(57 nodes) Chromatin DNA binding network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DHX9	DExH-box helicase 9. (1249 aa)
	LOC102346978	WBP2 N-terminal like. (202 aa)
	H1-0	H1 histone family member 0. (197 aa)
	WBP2	WW domain binding protein 2. (260 aa)
	CEBPB	CCAAT/enhancer-binding protein. (291 aa)
	EOMES	Eomesodermin. (419 aa)
	H3A3L7_LATCH	Uncharacterized protein. (392 aa)
	TBR1	T-box brain transcription factor 1. (673 aa)
	H3A552_LATCH	H15 domain-containing protein. (172 aa)
	PRDM14	PR/SET domain 14. (599 aa)
	THRB	Thyroid hormone receptor beta. (397 aa)
	KDM6A	Lysine (K)-specific demethylase 6A. (1452 aa)
	GRHL2	Grainyhead like transcription factor 2. (623 aa)
	KDM3A	Lysine demethylase 3A. (1319 aa)
	LOC102356872	H15 domain-containing protein. (199 aa)
	EP300	E1A binding protein p300. (1119 aa)
	KDM6B	Lysine demethylase 6B. (1638 aa)
	SIRT6	Sirtuin 6. (375 aa)
	LOC102352539	Uncharacterized protein. (949 aa)
	APEX1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (314 aa)
	H3AJV2_LATCH	PHD-type domain-containing protein. (679 aa)
	GATA1	GATA binding protein 1b. (432 aa)
	TOX	Thymocyte selection associated high mobility group box. (392 aa)
	NUP50	Nucleoporin 50. (469 aa)
	LEMD3	LEM domain containing 3. (705 aa)
	ATRX	ATRX chromatin remodeler. (2488 aa)
	THRA	Thyroid hormone receptor alpha. (408 aa)
	JMJD1C	Jumonji domain containing 1C. (2422 aa)
	LOC102359339	Uncharacterized protein. (107 aa)
	MACROH2A1	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (370 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	TOX2	TOX high mobility group box family member 2. (461 aa)
	KDM5A	Lysine demethylase 5A. (1695 aa)
	SBNO2	Strawberry notch homolog 2. (681 aa)
	TOX3	TOX high mobility group box family member 3. (540 aa)
	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase. (1048 aa)
	ZNF276	Zinc finger protein 276. (544 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (783 aa)
	H3B2C8_LATCH	Uncharacterized protein. (389 aa)
	TOX4	TOX high mobility group box family member 4. (626 aa)
	SRF	Serum response factor. (520 aa)
	MYOD1	Myogenic factor. (251 aa)
	MYOG	Myogenin. (242 aa)
	MACROH2A2	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (376 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (426 aa)
	PAX6	Paired box 6. (463 aa)
	LOC102353709	H1 histone family, member X. (214 aa)
	LEMD2	LEM domain containing 2. (416 aa)
	SUZ12	SUZ12 polycomb repressive complex 2 subunit. (711 aa)
	SBNO1	Strawberry notch homolog 1. (1396 aa)
	RCC1	Regulator of chromosome condensation 1. (422 aa)
	KDM3B	Lysine demethylase 3B. (1770 aa)
	RUVBL2	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (466 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (375 aa)
	POLE3	Polymerase (DNA directed), epsilon 3 (p17 subunit). (170 aa)
	CREBBP	CREB binding protein. (2411 aa)
	LOC102353964	H15 domain-containing protein. (332 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APEX1	CREBBP	ENSLACP00000009774	ENSLACP00000023096	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	CREB binding protein.	0.501
APEX1	EP300	ENSLACP00000009774	ENSLACP00000007844	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	E1A binding protein p300.	0.417
APEX1	LOC102352539	ENSLACP00000009774	ENSLACP00000009233	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Uncharacterized protein.	0.683
APEX1	POLE3	ENSLACP00000009774	ENSLACP00000022736	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Polymerase (DNA directed), epsilon 3 (p17 subunit).	0.700
ATRX	CREBBP	ENSLACP00000011544	ENSLACP00000023096	ATRX chromatin remodeler.	CREB binding protein.	0.438
ATRX	KDM6A	ENSLACP00000011544	ENSLACP00000006801	ATRX chromatin remodeler.	Lysine (K)-specific demethylase 6A.	0.449
ATRX	MACROH2A1	ENSLACP00000011544	ENSLACP00000013357	ATRX chromatin remodeler.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.518
ATRX	MACROH2A2	ENSLACP00000011544	ENSLACP00000016927	ATRX chromatin remodeler.	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.	0.477
ATRX	POLE3	ENSLACP00000011544	ENSLACP00000022736	ATRX chromatin remodeler.	Polymerase (DNA directed), epsilon 3 (p17 subunit).	0.408
ATRX	RUVBL2	ENSLACP00000011544	ENSLACP00000020365	ATRX chromatin remodeler.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.504
CEBPB	CREBBP	ENSLACP00000002325	ENSLACP00000023096	CCAAT/enhancer-binding protein.	CREB binding protein.	0.753
CEBPB	EP300	ENSLACP00000002325	ENSLACP00000007844	CCAAT/enhancer-binding protein.	E1A binding protein p300.	0.683
CEBPB	LOC102352539	ENSLACP00000002325	ENSLACP00000009233	CCAAT/enhancer-binding protein.	Uncharacterized protein.	0.847
CEBPB	PPARGC1A	ENSLACP00000002325	ENSLACP00000015962	CCAAT/enhancer-binding protein.	PPARG coactivator 1 alpha.	0.610
CEBPB	STAT3	ENSLACP00000002325	ENSLACP00000013656	CCAAT/enhancer-binding protein.	Signal transducer and activator of transcription.	0.823
CREBBP	APEX1	ENSLACP00000023096	ENSLACP00000009774	CREB binding protein.	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	0.501
CREBBP	ATRX	ENSLACP00000023096	ENSLACP00000011544	CREB binding protein.	ATRX chromatin remodeler.	0.438
CREBBP	CEBPB	ENSLACP00000023096	ENSLACP00000002325	CREB binding protein.	CCAAT/enhancer-binding protein.	0.753
CREBBP	DHX9	ENSLACP00000023096	ENSLACP00000020215	CREB binding protein.	DExH-box helicase 9.	0.529
CREBBP	GATA1	ENSLACP00000023096	ENSLACP00000010139	CREB binding protein.	GATA binding protein 1b.	0.714