(24 nodes) Lipopolysaccharide-mediated signaling pathway network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	MALT1	MALT1 paracaspase. (825 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (567 aa)
	PTAFR	Platelet activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	H3A8Y5_LATCH	Uncharacterized protein. (477 aa)
	LYN	Tyrosine-protein kinase. (515 aa)
	LTA	Lymphotoxin alpha. (166 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	H3AUI4_LATCH	Uncharacterized protein. (597 aa)
	BPIFB2	Uncharacterized protein. (487 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (673 aa)
	H3B0U4_LATCH	MALT paracaspase 2. (695 aa)
	LOC102357935	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (273 aa)
	H3B316_LATCH	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (332 aa)
	LOC102353021	Uncharacterized protein. (644 aa)
	H3B8S6_LATCH	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (316 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (286 aa)
	IRF3	Interferon regulatory factor 3. (481 aa)
	NFKBIA	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (298 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	IL18	Uncharacterized protein. (200 aa)
	BPIFB4	Uncharacterized protein. (473 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (521 aa)
	LOC102348796	Uncharacterized protein. (497 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H3AUI4_LATCH	IRAK1	ENSLACP00000013305	ENSLACP00000014884	Uncharacterized protein.	Interleukin 1 receptor associated kinase 1.	0.890
H3AUI4_LATCH	LOC102348796	ENSLACP00000013305	ENSLACP00000023619	Uncharacterized protein.	Uncharacterized protein.	0.484
H3AUI4_LATCH	MYD88	ENSLACP00000013305	ENSLACP00000019094	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.988
H3AUI4_LATCH	NFKBIA	ENSLACP00000013305	ENSLACP00000020134	Uncharacterized protein.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.563
H3AUI4_LATCH	RIPK2	ENSLACP00000013305	ENSLACP00000004499	Uncharacterized protein.	Receptor interacting serine/threonine kinase 2.	0.484
H3B0U4_LATCH	LOC102353021	ENSLACP00000015515	ENSLACP00000018014	MALT paracaspase 2.	Uncharacterized protein.	0.906
H3B0U4_LATCH	MALT1	ENSLACP00000015515	ENSLACP00000004155	MALT paracaspase 2.	MALT1 paracaspase.	0.902
H3B0U4_LATCH	NFKBIA	ENSLACP00000015515	ENSLACP00000020134	MALT paracaspase 2.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.506
IL18	IRAK1	ENSLACP00000021930	ENSLACP00000014884	Uncharacterized protein.	Interleukin 1 receptor associated kinase 1.	0.470
IL18	IRF3	ENSLACP00000021930	ENSLACP00000019335	Uncharacterized protein.	Interferon regulatory factor 3.	0.421
IL18	LTA	ENSLACP00000021930	ENSLACP00000007765	Uncharacterized protein.	Lymphotoxin alpha.	0.624
IL18	MYD88	ENSLACP00000021930	ENSLACP00000019094	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.792
IRAK1	H3AUI4_LATCH	ENSLACP00000014884	ENSLACP00000013305	Interleukin 1 receptor associated kinase 1.	Uncharacterized protein.	0.890
IRAK1	IL18	ENSLACP00000014884	ENSLACP00000021930	Interleukin 1 receptor associated kinase 1.	Uncharacterized protein.	0.470
IRAK1	IRF3	ENSLACP00000014884	ENSLACP00000019335	Interleukin 1 receptor associated kinase 1.	Interferon regulatory factor 3.	0.492
IRAK1	LOC102348796	ENSLACP00000014884	ENSLACP00000023619	Interleukin 1 receptor associated kinase 1.	Uncharacterized protein.	0.492
IRAK1	MYD88	ENSLACP00000014884	ENSLACP00000019094	Interleukin 1 receptor associated kinase 1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.990
IRAK1	NFKBIA	ENSLACP00000014884	ENSLACP00000020134	Interleukin 1 receptor associated kinase 1.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.717
IRAK1	RIPK2	ENSLACP00000014884	ENSLACP00000004499	Interleukin 1 receptor associated kinase 1.	Receptor interacting serine/threonine kinase 2.	0.514
IRF3	IL18	ENSLACP00000019335	ENSLACP00000021930	Interferon regulatory factor 3.	Uncharacterized protein.	0.421