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INO80D INO80D XRCC5 XRCC5 CCT3 CCT3 TFPT TFPT TERF2 TERF2 H3AJV2_LATCH H3AJV2_LATCH LOC102355250 LOC102355250 CCT2 CCT2 ATM ATM NAT10 NAT10 NAF1 NAF1 H3A560_LATCH H3A560_LATCH PARN PARN CCDC174 CCDC174 PPP1R10 PPP1R10 SMG6-2 SMG6-2 TNKS2 TNKS2 MAP3K4 MAP3K4 CCT5 CCT5 GNL3 GNL3 PIF1 PIF1 H2ZUG5_LATCH H2ZUG5_LATCH SMG6 SMG6 DCP2 DCP2 H2ZS42_LATCH H2ZS42_LATCH H2ZRJ8_LATCH H2ZRJ8_LATCH YLPM1 YLPM1 CCT4 CCT4 NFRKB NFRKB POT1 POT1 ERCC4 ERCC4 H3AC16_LATCH H3AC16_LATCH UCHL5 UCHL5 SIRT6 SIRT6 TNKS TNKS PINX1 PINX1 UPF1 UPF1 SMG1 SMG1 RUVBL2 RUVBL2 TEN1 TEN1 MYC MYC EXOSC10 EXOSC10 DHX36 DHX36 CTNNB1 CTNNB1 PNKP PNKP DKC1 DKC1 SLX4 SLX4 MAP2K7 MAP2K7 H3AZT0_LATCH H3AZT0_LATCH RUVBL1 RUVBL1 NEK2 NEK2 MAPKAPK5 MAPKAPK5 SMG5 SMG5 INO80 INO80 ACTR8 ACTR8 GNL3L GNL3L ATRX ATRX ATR ATR TENT4B TENT4B MCRS1 MCRS1 FBXO4 FBXO4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INO80DINO80 complex subunit D. (1051 aa)
XRCC5X-ray repair cross complementing 5. (606 aa)
CCT3T-complex protein 1 subunit gamma. (548 aa)
TFPTTCF3 (E2A) fusion partner. (254 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (489 aa)
H3AJV2_LATCHPHD-type domain-containing protein. (679 aa)
LOC102355250Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (264 aa)
CCT2Chaperonin containing TCP1 subunit 2. (535 aa)
ATMATM serine/threonine kinase. (2375 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1025 aa)
NAF1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (315 aa)
H3A560_LATCHRAD50 homolog, double strand break repair protein. (1193 aa)
PARNPoly(A)-specific ribonuclease. (529 aa)
CCDC174Coiled-coil domain containing 174. (449 aa)
PPP1R10Protein phosphatase 1 regulatory subunit 10. (792 aa)
SMG6-2PINc domain-containing protein. (465 aa)
TNKS2Poly [ADP-ribose] polymerase. (1174 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1425 aa)
CCT5Chaperonin containing TCP1 subunit 5. (554 aa)
GNL3G protein nucleolar 3. (564 aa)
PIF1ATP-dependent DNA helicase; Belongs to the helicase family. (630 aa)
H2ZUG5_LATCHINO80 complex subunit E. (83 aa)
SMG6SMG6 nonsense mediated mRNA decay factor. (803 aa)
DCP2Decapping mRNA 2. (402 aa)
H2ZS42_LATCHAAA_23 domain-containing protein. (88 aa)
H2ZRJ8_LATCHUncharacterized protein. (159 aa)
YLPM1YLP motif containing 1. (1900 aa)
CCT4T-complex protein 1 subunit delta. (535 aa)
NFRKBNuclear factor related to kappaB binding protein. (1198 aa)
POT1Protection of telomeres 1. (791 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (919 aa)
H3AC16_LATCHX-ray repair complementing defective repair in Chinese hamster cells 1. (649 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (329 aa)
SIRT6Sirtuin 6. (375 aa)
TNKSPoly [ADP-ribose] polymerase. (1233 aa)
PINX1Uncharacterized protein. (244 aa)
UPF1UPF1 RNA helicase and ATPase. (697 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3451 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (466 aa)
TEN1TEN1 subunit of CST complex. (123 aa)
MYCTranscriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (412 aa)
EXOSC10Exosome component 10. (910 aa)
DHX36DEAH-box helicase 36. (1001 aa)
CTNNB1Catenin beta 1. (781 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (611 aa)
DKC1Dyskerin pseudouridine synthase 1. (506 aa)
SLX4BTB domain-containing protein. (1393 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (439 aa)
H3AZT0_LATCHUncharacterized protein. (114 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (467 aa)
NEK2NIMA related kinase 2. (445 aa)
MAPKAPK5MAPK activated protein kinase 5. (471 aa)
SMG5SMG5 nonsense mediated mRNA decay factor. (1046 aa)
INO80INO80 complex ATPase subunit. (1542 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (631 aa)
GNL3LG protein nucleolar 3 like. (331 aa)
ATRXATRX chromatin remodeler. (2488 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2654 aa)
TENT4BTerminal nucleotidyltransferase 4B. (682 aa)
MCRS1Microspherule protein 1. (479 aa)
FBXO4F-box protein 4. (348 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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