(69 nodes) Regulation of lipid transport network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	ITGAV	Integrin_alpha2 domain-containing protein. (597 aa)
	C1QTNF6	C1q and TNF related 6. (273 aa)
	LPCAT3	Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (430 aa)
	LOC102357051	Galanin receptor 1b; Belongs to the G-protein coupled receptor 1 family. (331 aa)
	GALR1	Galanin receptor 1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	CRH	Corticotropin releasing hormone. (166 aa)
	PTCH1	Patched 1. (1287 aa)
	ABCG1	ATP binding cassette subfamily G member 1. (649 aa)
	YJEFN3	YjeF N-terminal domain containing 3. (202 aa)
	NUS1	NUS1 dehydrodolichyl diphosphate synthase subunit. (276 aa)
	PODN	Podocan. (621 aa)
	PLA2G6	Phospholipase A2 group VI. (815 aa)
	H3ADE5_LATCH	Uncharacterized protein. (642 aa)
	EEPD1	Endonuclease/exonuclease/phosphatase family domain containing 1. (580 aa)
	TTC39A	Tetratricopeptide repeat domain 39A. (557 aa)
	SIRT1	Sirtuin 1. (729 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (169 aa)
	LOC102351706	PRELI domain containing 1b. (213 aa)
	CRY1	Cryptochrome circadian regulator 1. (653 aa)
	ACSL1	Acyl-CoA synthetase long chain family member 1. (702 aa)
	TTC39B	Tetratricopeptide repeat domain 39B. (559 aa)
	H3AM01_LATCH	Integrin beta; Belongs to the integrin beta chain family. (769 aa)
	NAXE	NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (292 aa)
	PCSK9	Proprotein convertase subtilisin/kexin type 9. (672 aa)
	H3AN39_LATCH	Uncharacterized protein. (274 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	LOC102365364	Cryptochrome circadian regulator 3a. (616 aa)
	ACSL5	Acyl-CoA synthetase long chain family member 5. (683 aa)
	BMP6	Bone morphogenetic protein 6. (428 aa)
	LOC102365880	G_PROTEIN_RECEP_F1_2 domain-containing protein. (323 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	POMC	Proopiomelanocortin. (255 aa)
	EPRS1	Glutamyl-prolyl-tRNA synthetase. (1965 aa)
	PRELID1	PRELI domain containing 1. (216 aa)
	LDLRAP1	Low density lipoprotein receptor adaptor protein 1b. (316 aa)
	KDM5B	Lysine demethylase 5B. (1659 aa)
	H3AWN2_LATCH	Cryptochrome circadian regulator 4. (531 aa)
	H3AXK0_LATCH	Uncharacterized protein. (161 aa)
	SURF4	Surfeit 4. (272 aa)
	H3AYF7_LATCH	Zgc:153896. (403 aa)
	DAB2	DAB adaptor protein 2. (745 aa)
	C1QTNF9	C1q domain-containing protein. (198 aa)
	GHRL	Motilin_assoc domain-containing protein. (110 aa)
	PODNL1	Podocan like 1. (599 aa)
	TMF1	TATA element modulatory factor 1. (1135 aa)
	ABCA12	ATP binding cassette subfamily A member 12. (2171 aa)
	LOC102365063	Apolipoprotein A-IV b, tandem duplicate 2. (252 aa)
	APOA4	Apolipoprotein A4. (367 aa)
	ABCG8	ATP binding cassette subfamily G member 8. (677 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (426 aa)
	LOC102349441	Zgc:158403. (426 aa)
	FASLG	Fas ligand. (261 aa)
	ABCG5	ATP binding cassette subfamily G member 5. (438 aa)
	ARV1	ARV1 homolog, fatty acid homeostasis modulator. (232 aa)
	C1QTNF1	C1q and TNF related 1. (229 aa)
	LOC102346019	C1q domain-containing protein. (226 aa)
	NFKBIA	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (298 aa)
	H3BE69_LATCH	PID domain-containing protein. (136 aa)
	ABCG4	ATP binding cassette subfamily G member 4. (653 aa)
	ENPP7	Ectonucleotide pyrophosphatase/phosphodiesterase 7. (476 aa)
	THBS1	Thrombospondin 1. (1170 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
	CRY2	Cryptochrome circadian regulator 2. (434 aa)
	PLTP	Phospholipid transfer protein. (495 aa)
	LOC102365447	Uncharacterized protein. (521 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (375 aa)
	PTGES	Prostaglandin E synthase. (146 aa)
	APOA1	Uncharacterized protein. (237 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA12	LOC102365063	ENSLACP00000016181	ENSLACP00000016264	ATP binding cassette subfamily A member 12.	Apolipoprotein A-IV b, tandem duplicate 2.	0.549
ABCA12	PCSK9	ENSLACP00000016181	ENSLACP00000011043	ATP binding cassette subfamily A member 12.	Proprotein convertase subtilisin/kexin type 9.	0.446
ABCG1	ABCG5	ENSLACP00000004101	ENSLACP00000017950	ATP binding cassette subfamily G member 1.	ATP binding cassette subfamily G member 5.	0.848
ABCG1	LOC102365063	ENSLACP00000004101	ENSLACP00000016264	ATP binding cassette subfamily G member 1.	Apolipoprotein A-IV b, tandem duplicate 2.	0.646
ABCG1	PLTP	ENSLACP00000004101	ENSLACP00000021320	ATP binding cassette subfamily G member 1.	Phospholipid transfer protein.	0.418
ABCG4	ABCG5	ENSLACP00000020332	ENSLACP00000017950	ATP binding cassette subfamily G member 4.	ATP binding cassette subfamily G member 5.	0.836
ABCG4	LOC102365063	ENSLACP00000020332	ENSLACP00000016264	ATP binding cassette subfamily G member 4.	Apolipoprotein A-IV b, tandem duplicate 2.	0.646
ABCG4	PLTP	ENSLACP00000020332	ENSLACP00000021320	ATP binding cassette subfamily G member 4.	Phospholipid transfer protein.	0.418
ABCG5	ABCG1	ENSLACP00000017950	ENSLACP00000004101	ATP binding cassette subfamily G member 5.	ATP binding cassette subfamily G member 1.	0.848
ABCG5	ABCG4	ENSLACP00000017950	ENSLACP00000020332	ATP binding cassette subfamily G member 5.	ATP binding cassette subfamily G member 4.	0.836
ABCG5	ABCG8	ENSLACP00000017950	ENSLACP00000016915	ATP binding cassette subfamily G member 5.	ATP binding cassette subfamily G member 8.	0.999
ABCG5	APOA4	ENSLACP00000017950	ENSLACP00000016757	ATP binding cassette subfamily G member 5.	Apolipoprotein A4.	0.415
ABCG5	LOC102365063	ENSLACP00000017950	ENSLACP00000016264	ATP binding cassette subfamily G member 5.	Apolipoprotein A-IV b, tandem duplicate 2.	0.592
ABCG5	NR1H2	ENSLACP00000017950	ENSLACP00000017222	ATP binding cassette subfamily G member 5.	Nuclear receptor subfamily 1 group H member 2.	0.437
ABCG5	NR1H3	ENSLACP00000017950	ENSLACP00000021584	ATP binding cassette subfamily G member 5.	Nuclear receptor subfamily 1 group H member 3.	0.437
ABCG8	ABCG5	ENSLACP00000016915	ENSLACP00000017950	ATP binding cassette subfamily G member 8.	ATP binding cassette subfamily G member 5.	0.999
ABCG8	LOC102365063	ENSLACP00000016915	ENSLACP00000016264	ATP binding cassette subfamily G member 8.	Apolipoprotein A-IV b, tandem duplicate 2.	0.564
ABCG8	NR1H2	ENSLACP00000016915	ENSLACP00000017222	ATP binding cassette subfamily G member 8.	Nuclear receptor subfamily 1 group H member 2.	0.414
ABCG8	NR1H3	ENSLACP00000016915	ENSLACP00000021584	ATP binding cassette subfamily G member 8.	Nuclear receptor subfamily 1 group H member 3.	0.414
ABCG8	PLTP	ENSLACP00000016915	ENSLACP00000021320	ATP binding cassette subfamily G member 8.	Phospholipid transfer protein.	0.422