(66 nodes) Endocytic recycling network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SNX27	Sorting nexin 27. (559 aa)
	VPS50	VPS50 subunit of EARP/GARPII complex. (964 aa)
	ATP6AP1	ATPase H+ transporting accessory protein 1. (474 aa)
	RAB11FIP4	RAB11 family interacting protein 4. (530 aa)
	H2ZTQ8_LATCH	Uncharacterized protein. (878 aa)
	LRRC1	Uncharacterized protein. (155 aa)
	PTPN23	Protein tyrosine phosphatase non-receptor type 23. (1414 aa)
	GRIP1	Glutamate receptor interacting protein 1. (938 aa)
	MICALL2	Uncharacterized protein. (800 aa)
	WASHC1	WASH complex subunit 1. (474 aa)
	HGS	Hepatocyte growth factor-regulated tyrosine kinase substrate. (480 aa)
	DENND1A	DENN domain containing 1A. (1001 aa)
	LOC102349333	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (176 aa)
	RAB35	RAB35, member RAS oncogene family. (203 aa)
	EHD2	EH-domain containing 2a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (482 aa)
	EHD1	EH domain containing 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (536 aa)
	ENTR1	Endosome associated trafficking regulator 1. (355 aa)
	EHD4	EH domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (591 aa)
	RAB11FIP3	RAB11 family interacting protein 3. (497 aa)
	RAB11B	RAB11B, member RAS oncogene family. (172 aa)
	LOC102363089	RAB11B, member RAS oncogene family, b. (228 aa)
	SNF8	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
	VPS29	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. (204 aa)
	RAB7A	RAB7A, member RAS oncogene family. (207 aa)
	SNX3	Sorting nexin 3. (108 aa)
	H3B7E6_LATCH	Uncharacterized protein. (237 aa)
	STX6	Syntaxin 6; Belongs to the syntaxin family. (265 aa)
	SNX30	Sorting nexin family member 30. (513 aa)
	STX10	Syntaxin 10. (252 aa)
	TRARG1	Trafficking regulator of GLUT4 (SLC2A4) 1. (181 aa)
	CMTM6	CKLF like MARVEL transmembrane domain containing 6. (186 aa)
	VPS35L	VPS35 endosomal protein sorting factor like. (840 aa)
	VPS52	VPS52 subunit of GARP complex. (528 aa)
	RAB11A	RAB11A, member RAS oncogene family. (215 aa)
	LOC102357106	RAB11a, member RAS oncogene family, like. (217 aa)
	VPS26C	VPS26 endosomal protein sorting factor C. (295 aa)
	RAB14	RAB14, member RAS oncogene family. (234 aa)
	LOC102358523	Uncharacterized protein. (424 aa)
	SNX7	Sorting nexin 7. (426 aa)
	DENND1B	UDENN domain-containing protein. (268 aa)
	VPS53	VPS53 subunit of GARP complex. (831 aa)
	SNX12	Sorting nexin 12. (174 aa)
	H3ANE5_LATCH	BRO1 domain-containing protein. (170 aa)
	H3AN78_LATCH	Ankyrin repeat domain 50-like. (1410 aa)
	VPS35	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (790 aa)
	ANKRD27	Ankyrin repeat domain 27. (888 aa)
	H3ALU1_LATCH	Uncharacterized protein. (1358 aa)
	H3AKJ7_LATCH	DENN/MADD domain containing 1B. (493 aa)
	LOC102352152	Uncharacterized protein. (206 aa)
	SNX4	Sorting nexin 4. (405 aa)
	H3AFQ9_LATCH	Uncharacterized protein. (481 aa)
	VPS26A	VPS26, retromer complex component A. (326 aa)
	VPS51	VPS51 subunit of GARP complex. (756 aa)
	ANKRD50	Ankyrin repeat domain 50. (1418 aa)
	VPS39	VPS39 subunit of HOPS complex. (875 aa)
	ANKRD63	ANK_REP_REGION domain-containing protein. (509 aa)
	EPG5	Ectopic P-granules autophagy protein 5 homolog (C. elegans). (1395 aa)
	ARF6	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
	CCDC22	Coiled-coil domain containing 22. (647 aa)
	EHD3	EH domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (535 aa)
	SNX17	Sorting nexin 17. (455 aa)
	GRIP2	Glutamate receptor interacting protein 2. (1064 aa)
	GGA3	Golgi associated, gamma adaptin ear containing, ARF binding protein 3. (736 aa)
	EIPR1	EARP complex and GARP complex interacting protein 1. (387 aa)
	H2ZYW4_LATCH	ANK_REP_REGION domain-containing protein. (149 aa)
	GRIPAP1	GRIP1 associated protein 1. (826 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD27	VPS29	ENSLACP00000010784	ENSLACP00000017987	Ankyrin repeat domain 27.	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	0.891
ANKRD27	VPS35	ENSLACP00000010784	ENSLACP00000010975	Ankyrin repeat domain 27.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.575
ANKRD50	VPS29	ENSLACP00000007019	ENSLACP00000017987	Ankyrin repeat domain 50.	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	0.513
ANKRD50	VPS35	ENSLACP00000007019	ENSLACP00000010975	Ankyrin repeat domain 50.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.416
ANKRD63	VPS29	ENSLACP00000006289	ENSLACP00000017987	ANK_REP_REGION domain-containing protein.	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	0.513
ANKRD63	VPS35	ENSLACP00000006289	ENSLACP00000010975	ANK_REP_REGION domain-containing protein.	Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.	0.416
ARF6	GGA3	ENSLACP00000005263	ENSLACP00000003686	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	Golgi associated, gamma adaptin ear containing, ARF binding protein 3.	0.876
ARF6	H3ANE5_LATCH	ENSLACP00000005263	ENSLACP00000011166	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	BRO1 domain-containing protein.	0.427
ARF6	LOC102349333	ENSLACP00000005263	ENSLACP00000021262	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.900
ARF6	PTPN23	ENSLACP00000005263	ENSLACP00000000577	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	Protein tyrosine phosphatase non-receptor type 23.	0.427
ARF6	RAB11FIP3	ENSLACP00000005263	ENSLACP00000019925	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	RAB11 family interacting protein 3.	0.637
ARF6	RAB11FIP4	ENSLACP00000005263	ENSLACP00000001170	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	RAB11 family interacting protein 4.	0.501
ARF6	RAB35	ENSLACP00000005263	ENSLACP00000020991	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	RAB35, member RAS oncogene family.	0.512
CCDC22	SNX17	ENSLACP00000005078	ENSLACP00000004532	Coiled-coil domain containing 22.	Sorting nexin 17.	0.418
CCDC22	VPS26C	ENSLACP00000005078	ENSLACP00000012798	Coiled-coil domain containing 22.	VPS26 endosomal protein sorting factor C.	0.870
CCDC22	VPS29	ENSLACP00000005078	ENSLACP00000017987	Coiled-coil domain containing 22.	Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.	0.746
CCDC22	VPS35L	ENSLACP00000005078	ENSLACP00000014228	Coiled-coil domain containing 22.	VPS35 endosomal protein sorting factor like.	0.917
CCDC22	VPS50	ENSLACP00000005078	ENSLACP00000002124	Coiled-coil domain containing 22.	VPS50 subunit of EARP/GARPII complex.	0.426
CMTM6	VPS26A	ENSLACP00000015077	ENSLACP00000008452	CKLF like MARVEL transmembrane domain containing 6.	VPS26, retromer complex component A.	0.418
DENND1A	DENND1B	ENSLACP00000022367	ENSLACP00000011615	DENN domain containing 1A.	UDENN domain-containing protein.	0.642