(31 nodes) Endosome transport via multivesicular body sorting pathway network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTPN23	Protein tyrosine phosphatase non-receptor type 23. (1414 aa)
	UBXN6	UBX domain protein 6. (439 aa)
	LEPROTL1	Leptin receptor overlapping transcript like 1. (131 aa)
	CHMP1B	Charged multivesicular body protein 1B. (161 aa)
	LYST	Lysosomal trafficking regulator. (3705 aa)
	VTA1	Vta1 domain-containing protein. (43 aa)
	CHMP4A	Charged multivesicular body protein 4A. (221 aa)
	CHMP5	Charged multivesicular body protein 5. (220 aa)
	CHMP2A	Charged multivesicular body protein 2A. (295 aa)
	CHMP4B	Charged multivesicular body protein 4B. (225 aa)
	VPS36	Vacuolar protein sorting 36 homolog. (261 aa)
	LEPROT	Leptin receptor overlapping transcript. (131 aa)
	LAPTM4B	Lysosomal protein transmembrane 4 beta. (117 aa)
	CHMP4C	Uncharacterized protein. (240 aa)
	H3ANE5_LATCH	BRO1 domain-containing protein. (170 aa)
	VCP	Valosin containing protein. (801 aa)
	STAM	Signal transducing adaptor molecule. (537 aa)
	VPS28	VPS28 subunit of ESCRT-I; Belongs to the VPS28 family. (180 aa)
	TMEM50B	Transmembrane protein 50B. (158 aa)
	CHMP2B	Charged multivesicular body protein 2B. (214 aa)
	DENND10	DENN domain containing 10. (352 aa)
	CHMP1A	Charged multivesicular body protein 1A. (206 aa)
	CHMP7	Charged multivesicular body protein 7. (453 aa)
	SORT1	Sortilin. (734 aa)
	CHMP6	Charged multivesicular body protein 6. (146 aa)
	TMEM50A	Transmembrane protein 50A. (159 aa)
	LOC102365663	Zgc:136908; Belongs to the AAA ATPase family. (697 aa)
	MVB12A	Multivesicular body subunit 12A. (273 aa)
	SNF8	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
	LOC102345670	Sortilin. (809 aa)
	RILP	Rab interacting lysosomal protein. (423 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHMP1A	CHMP1B	ENSLACP00000016874	ENSLACP00000003969	Charged multivesicular body protein 1A.	Charged multivesicular body protein 1B.	0.902
CHMP1A	CHMP2A	ENSLACP00000016874	ENSLACP00000005772	Charged multivesicular body protein 1A.	Charged multivesicular body protein 2A.	0.993
CHMP1A	CHMP2B	ENSLACP00000016874	ENSLACP00000016376	Charged multivesicular body protein 1A.	Charged multivesicular body protein 2B.	0.962
CHMP1A	CHMP4A	ENSLACP00000016874	ENSLACP00000005231	Charged multivesicular body protein 1A.	Charged multivesicular body protein 4A.	0.969
CHMP1A	CHMP4B	ENSLACP00000016874	ENSLACP00000006004	Charged multivesicular body protein 1A.	Charged multivesicular body protein 4B.	0.969
CHMP1A	CHMP4C	ENSLACP00000016874	ENSLACP00000009207	Charged multivesicular body protein 1A.	Uncharacterized protein.	0.704
CHMP1A	CHMP5	ENSLACP00000016874	ENSLACP00000005733	Charged multivesicular body protein 1A.	Charged multivesicular body protein 5.	0.991
CHMP1A	CHMP6	ENSLACP00000016874	ENSLACP00000017820	Charged multivesicular body protein 1A.	Charged multivesicular body protein 6.	0.704
CHMP1A	CHMP7	ENSLACP00000016874	ENSLACP00000017181	Charged multivesicular body protein 1A.	Charged multivesicular body protein 7.	0.958
CHMP1A	MVB12A	ENSLACP00000016874	ENSLACP00000018309	Charged multivesicular body protein 1A.	Multivesicular body subunit 12A.	0.511
CHMP1A	SNF8	ENSLACP00000016874	ENSLACP00000018637	Charged multivesicular body protein 1A.	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.	0.684
CHMP1A	VPS28	ENSLACP00000016874	ENSLACP00000015289	Charged multivesicular body protein 1A.	VPS28 subunit of ESCRT-I; Belongs to the VPS28 family.	0.728
CHMP1A	VPS36	ENSLACP00000016874	ENSLACP00000006360	Charged multivesicular body protein 1A.	Vacuolar protein sorting 36 homolog.	0.719
CHMP1A	VTA1	ENSLACP00000016874	ENSLACP00000004525	Charged multivesicular body protein 1A.	Vta1 domain-containing protein.	0.992
CHMP1B	CHMP1A	ENSLACP00000003969	ENSLACP00000016874	Charged multivesicular body protein 1B.	Charged multivesicular body protein 1A.	0.902
CHMP1B	CHMP2A	ENSLACP00000003969	ENSLACP00000005772	Charged multivesicular body protein 1B.	Charged multivesicular body protein 2A.	0.993
CHMP1B	CHMP2B	ENSLACP00000003969	ENSLACP00000016376	Charged multivesicular body protein 1B.	Charged multivesicular body protein 2B.	0.962
CHMP1B	CHMP4A	ENSLACP00000003969	ENSLACP00000005231	Charged multivesicular body protein 1B.	Charged multivesicular body protein 4A.	0.969
CHMP1B	CHMP4B	ENSLACP00000003969	ENSLACP00000006004	Charged multivesicular body protein 1B.	Charged multivesicular body protein 4B.	0.969
CHMP1B	CHMP4C	ENSLACP00000003969	ENSLACP00000009207	Charged multivesicular body protein 1B.	Uncharacterized protein.	0.704