49 items (Latimeria chalumnae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ITGAV	Integrin_alpha2 domain-containing protein. (597 aa)
	LOC102352818	PH domain-containing protein. (249 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (484 aa)
	H2ZTT6_LATCH	Phosphoinositide phospholipase C. (404 aa)
	C2CD5	C2 calcium dependent domain containing 5. (581 aa)
	SH3YL1	SH3 and SYLF domain containing 1. (341 aa)
	LOC102352804	Phosphoinositide phospholipase C. (1172 aa)
	H3A551_LATCH	Phosphodiesterase. (437 aa)
	PLA2G4F	Phospholipase A2. (785 aa)
	EPS8	Epidermal growth factor receptor pathway substrate 8. (774 aa)
	H3A6W7_LATCH	C2 domain-containing protein. (310 aa)
	CLASP2	Cytoplasmic linker associated protein 2. (1303 aa)
	EZR	Ezrin. (591 aa)
	RPS3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (254 aa)
	JCAD	Junctional cadherin 5 associated. (1240 aa)
	LOC102349512	Uncharacterized protein. (524 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (476 aa)
	EPS8L3	EPS8 like 3. (526 aa)
	ARHGEF2	Rho/Rac guanine nucleotide exchange factor 2. (1027 aa)
	PIP5K1A	Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (878 aa)
	MYO6	Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1230 aa)
	H3AM01_LATCH	Integrin beta; Belongs to the integrin beta chain family. (769 aa)
	PDE9A	Phosphodiesterase. (519 aa)
	MTMR9	Myotubularin related protein 9. (554 aa)
	EPHA2	Uncharacterized protein. (979 aa)
	MTSS2	MTSS I-BAR domain containing 2. (674 aa)
	PSD2	Pleckstrin and Sec7 domain containing 2. (646 aa)
	SPRY4	Sprouty RTK signaling antagonist 4. (282 aa)
	PLEKHO1	Pleckstrin homology domain containing O1. (362 aa)
	LOC102363010	Si:ch211-51c14.1. (475 aa)
	SPATA13	Spermatogenesis associated 13. (559 aa)
	ARHGAP45	Rho GTPase activating protein 45. (1026 aa)
	H3B2B0_LATCH	SH3 domain-containing protein. (763 aa)
	EPB41L5	Erythrocyte membrane protein band 4.1 like 5. (506 aa)
	H3B2J7_LATCH	Uncharacterized protein. (575 aa)
	PIP5K1C	Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (646 aa)
	LOC102360622	Phosphodiesterase. (504 aa)
	LOC102362769	Protein tyrosine phosphatase receptor type Jb, tandem duplicate 2. (358 aa)
	PLEK	Pleckstrin. (353 aa)
	PSD	Pleckstrin and Sec7 domain containing. (496 aa)
	CIB1	Calcium and integrin binding 1. (190 aa)
	AIF1L	Allograft inflammatory factor 1 like. (148 aa)
	PACSIN1	Protein kinase C and casein kinase substrate in neurons 1. (490 aa)
	PACSIN2	Protein kinase C and casein kinase substrate in neurons 2. (330 aa)
	CIB3	Calcium and integrin binding family member 3. (209 aa)
	HIP1R	Huntingtin interacting protein 1 related. (1039 aa)
	TIRAP	TIR domain containing adaptor protein. (267 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1219 aa)
	EPS8L2	EPS8 like 2. (761 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APPL2	PLEK	ENSLACP00000000307	ENSLACP00000018332	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Pleckstrin.	0.420
C2CD5	H3A6W7_LATCH	ENSLACP00000000929	ENSLACP00000005388	C2 calcium dependent domain containing 5.	C2 domain-containing protein.	0.928
EPB41L5	LOC102362769	ENSLACP00000016100	ENSLACP00000018269	Erythrocyte membrane protein band 4.1 like 5.	Protein tyrosine phosphatase receptor type Jb, tandem duplicate 2.	0.429
EPS8L3	MTSS2	ENSLACP00000008102	ENSLACP00000013362	EPS8 like 3.	MTSS I-BAR domain containing 2.	0.764
H3A6W7_LATCH	C2CD5	ENSLACP00000005388	ENSLACP00000000929	C2 domain-containing protein.	C2 calcium dependent domain containing 5.	0.928
H3AM01_LATCH	ITGAV	ENSLACP00000010672	ENSLACP00000000513	Integrin beta; Belongs to the integrin beta chain family.	Integrin_alpha2 domain-containing protein.	0.998
H3B2J7_LATCH	SPATA13	ENSLACP00000016118	ENSLACP00000015637	Uncharacterized protein.	Spermatogenesis associated 13.	0.900
INPP5K	PLCG1	ENSLACP00000008065	ENSLACP00000021632	Inositol polyphosphate-5-phosphatase K.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.705
ITGAV	H3AM01_LATCH	ENSLACP00000000513	ENSLACP00000010672	Integrin_alpha2 domain-containing protein.	Integrin beta; Belongs to the integrin beta chain family.	0.998
LOC102362769	EPB41L5	ENSLACP00000018269	ENSLACP00000016100	Protein tyrosine phosphatase receptor type Jb, tandem duplicate 2.	Erythrocyte membrane protein band 4.1 like 5.	0.429
MTSS2	EPS8L3	ENSLACP00000013362	ENSLACP00000008102	MTSS I-BAR domain containing 2.	EPS8 like 3.	0.764
PACSIN1	PACSIN2	ENSLACP00000019394	ENSLACP00000019714	Protein kinase C and casein kinase substrate in neurons 1.	Protein kinase C and casein kinase substrate in neurons 2.	0.913
PACSIN2	PACSIN1	ENSLACP00000019714	ENSLACP00000019394	Protein kinase C and casein kinase substrate in neurons 2.	Protein kinase C and casein kinase substrate in neurons 1.	0.913
PIP5K1A	PLCG1	ENSLACP00000008573	ENSLACP00000021632	Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.917
PIP5K1A	RPS3	ENSLACP00000008573	ENSLACP00000006908	Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha.	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family.	0.409
PIP5K1C	RPS3	ENSLACP00000016495	ENSLACP00000006908	Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma.	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family.	0.409
PLA2G4F	PLCG1	ENSLACP00000004886	ENSLACP00000021632	Phospholipase A2.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.901
PLCG1	INPP5K	ENSLACP00000021632	ENSLACP00000008065	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Inositol polyphosphate-5-phosphatase K.	0.705
PLCG1	PIP5K1A	ENSLACP00000021632	ENSLACP00000008573	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha.	0.917
PLCG1	PLA2G4F	ENSLACP00000021632	ENSLACP00000004886	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	Phospholipase A2.	0.901