(28 nodes) Positive regulation of chemokine production network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	SYK	Tyrosine-protein kinase. (616 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (766 aa)
	ADAM17	ADAM metallopeptidase domain 17. (827 aa)
	LOC102349920	Uncharacterized protein. (199 aa)
	IL6	Uncharacterized protein. (149 aa)
	H3AGM7_LATCH	Fibronectin type-III domain-containing protein. (234 aa)
	TIRAP	TIR domain containing adaptor protein. (267 aa)
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	LOC102358678	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (304 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	H2ZSX8_LATCH	Fibronectin type-III domain-containing protein. (243 aa)
	APP	Amyloid beta precursor protein. (652 aa)
	LOC102367457	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (312 aa)
	TRIM32	Tripartite motif containing 32. (647 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (567 aa)
	EIF2AK2	Protein kinase domain-containing protein. (292 aa)
	MBP	Myelin basic protein. (133 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	CARD9	Caspase recruitment domain family member 9. (567 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (286 aa)
	IL18	Uncharacterized protein. (200 aa)
	H3B9K7_LATCH	SEFIR domain-containing protein. (774 aa)
	MCOLN2	Mucolipin 2. (538 aa)
	CD74	CD74 molecule. (279 aa)
	CSF1R	Colony stimulating factor 1 receptor. (968 aa)
	C5	Complement C5. (1691 aa)
	LOC102348796	Uncharacterized protein. (497 aa)
	IL6R	Interleukin 6 receptor. (469 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM17	APP	ENSLACP00000010665	ENSLACP00000001643	ADAM metallopeptidase domain 17.	Amyloid beta precursor protein.	0.457
ADIPOQ	IL6	ENSLACP00000000452	ENSLACP00000009318	Adiponectin, C1Q and collagen domain containing.	Uncharacterized protein.	0.767
APP	ADAM17	ENSLACP00000001643	ENSLACP00000010665	Amyloid beta precursor protein.	ADAM metallopeptidase domain 17.	0.457
APP	CD74	ENSLACP00000001643	ENSLACP00000018188	Amyloid beta precursor protein.	CD74 molecule.	0.700
APP	IL6	ENSLACP00000001643	ENSLACP00000009318	Amyloid beta precursor protein.	Uncharacterized protein.	0.443
APP	MBP	ENSLACP00000001643	ENSLACP00000022061	Amyloid beta precursor protein.	Myelin basic protein.	0.440
CARD9	LOC102348796	ENSLACP00000020146	ENSLACP00000023619	Caspase recruitment domain family member 9.	Uncharacterized protein.	0.936
CARD9	MYD88	ENSLACP00000020146	ENSLACP00000019094	Caspase recruitment domain family member 9.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.547
CARD9	RIPK2	ENSLACP00000020146	ENSLACP00000004499	Caspase recruitment domain family member 9.	Receptor interacting serine/threonine kinase 2.	0.936
CARD9	SYK	ENSLACP00000020146	ENSLACP00000012982	Caspase recruitment domain family member 9.	Tyrosine-protein kinase.	0.970
CD74	APP	ENSLACP00000018188	ENSLACP00000001643	CD74 molecule.	Amyloid beta precursor protein.	0.700
CD74	CSF1R	ENSLACP00000018188	ENSLACP00000016266	CD74 molecule.	Colony stimulating factor 1 receptor.	0.602
CSF1R	CD74	ENSLACP00000016266	ENSLACP00000018188	Colony stimulating factor 1 receptor.	CD74 molecule.	0.602
CSF1R	IL6	ENSLACP00000016266	ENSLACP00000009318	Colony stimulating factor 1 receptor.	Uncharacterized protein.	0.454
CSF1R	TLR3	ENSLACP00000016266	ENSLACP00000012956	Colony stimulating factor 1 receptor.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.450
EIF2AK2	MYD88	ENSLACP00000007014	ENSLACP00000019094	Protein kinase domain-containing protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.417
EIF2AK2	TLR3	ENSLACP00000007014	ENSLACP00000012956	Protein kinase domain-containing protein.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.494
H2ZS97_LATCH	IL6	ENSLACP00000000268	ENSLACP00000009318	TNF_2 domain-containing protein.	Uncharacterized protein.	0.470
H3AEV1_LATCH	IL6	ENSLACP00000008172	ENSLACP00000009318	TNF_2 domain-containing protein.	Uncharacterized protein.	0.470
IL18	IL6	ENSLACP00000021930	ENSLACP00000009318	Uncharacterized protein.	Uncharacterized protein.	0.857