(25 nodes) Muscle cell proliferation network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GATA6	GATA binding protein 6. (503 aa)
	MEGF10	Multiple EGF like domains 10. (1124 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (163 aa)
	SAV1	Salvador family WW domain containing protein 1. (393 aa)
	H3B181_LATCH	Teneurin transmembrane protein 4. (1031 aa)
	NKX2-5	NK2 homeobox 5. (296 aa)
	H3B6N2_LATCH	Teneurin N-terminal domain-containing protein. (214 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	H3B938_LATCH	Teneurin N-terminal domain-containing protein. (181 aa)
	NF1	Neurofibromin 1. (2814 aa)
	LOC102352268	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	DDIT3	DNA damage inducible transcript 3. (256 aa)
	HGF	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (720 aa)
	H2ZZR1_LATCH	Uncharacterized protein. (209 aa)
	CALCRL	Calcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (465 aa)
	POLDIP2	DNA polymerase delta interacting protein 2. (369 aa)
	DIPK2A	Divergent protein kinase domain 2A. (434 aa)
	LOC102365031	ApaG domain-containing protein. (345 aa)
	ARID2	AT-rich interaction domain 2. (1771 aa)
	KPNA1	Importin subunit alpha; Belongs to the importin alpha family. (538 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
	CCN3	Cellular communication network factor 3. (345 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (906 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GATA6	KPNA1	ENSLACP00000002849	ENSLACP00000005797	GATA binding protein 6.	Importin subunit alpha; Belongs to the importin alpha family.	0.423
GATA6	NF1	ENSLACP00000002849	ENSLACP00000019331	GATA binding protein 6.	Neurofibromin 1.	0.401
GATA6	NKX2-5	ENSLACP00000002849	ENSLACP00000016921	GATA binding protein 6.	NK2 homeobox 5.	0.814
H3B181_LATCH	H3B6N2_LATCH	ENSLACP00000015652	ENSLACP00000017553	Teneurin transmembrane protein 4.	Teneurin N-terminal domain-containing protein.	0.900
H3B181_LATCH	H3B938_LATCH	ENSLACP00000015652	ENSLACP00000018409	Teneurin transmembrane protein 4.	Teneurin N-terminal domain-containing protein.	0.900
H3B6N2_LATCH	H3B181_LATCH	ENSLACP00000017553	ENSLACP00000015652	Teneurin N-terminal domain-containing protein.	Teneurin transmembrane protein 4.	0.900
H3B6N2_LATCH	H3B938_LATCH	ENSLACP00000017553	ENSLACP00000018409	Teneurin N-terminal domain-containing protein.	Teneurin N-terminal domain-containing protein.	0.942
H3B938_LATCH	H3B181_LATCH	ENSLACP00000018409	ENSLACP00000015652	Teneurin N-terminal domain-containing protein.	Teneurin transmembrane protein 4.	0.900
H3B938_LATCH	H3B6N2_LATCH	ENSLACP00000018409	ENSLACP00000017553	Teneurin N-terminal domain-containing protein.	Teneurin N-terminal domain-containing protein.	0.942
KPNA1	GATA6	ENSLACP00000005797	ENSLACP00000002849	Importin subunit alpha; Belongs to the importin alpha family.	GATA binding protein 6.	0.423
LOC102352268	TGFB2	ENSLACP00000019574	ENSLACP00000007733	Transforming growth factor beta; Belongs to the TGF-beta family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.901
NF1	GATA6	ENSLACP00000019331	ENSLACP00000002849	Neurofibromin 1.	GATA binding protein 6.	0.401
NKX2-5	GATA6	ENSLACP00000016921	ENSLACP00000002849	NK2 homeobox 5.	GATA binding protein 6.	0.814
TGFB2	LOC102352268	ENSLACP00000007733	ENSLACP00000019574	Transforming growth factor beta; Belongs to the TGF-beta family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.901