(37 nodes) Tetrapyrrole metabolic process network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HMOX1	Heme oxygenase 1. (300 aa)
	LOC102358857	Cytochrome c oxidase assembly homolog 15 (yeast). (251 aa)
	BDH2	3-hydroxybutyrate dehydrogenase 2. (249 aa)
	H2ZVR1_LATCH	Uncharacterized protein. (167 aa)
	TCN2	DUF4430 domain-containing protein. (431 aa)
	LOC102348382	DUF4430 domain-containing protein. (427 aa)
	PPOX	Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (479 aa)
	UROS	Uroporphyrinogen III synthase. (261 aa)
	ATP5IF1	ATP synthase inhibitory factor subunit 1a. (110 aa)
	ABCB10	ATP binding cassette subfamily B member 10. (723 aa)
	HMOX2	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (319 aa)
	H3AEB8_LATCH	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (147 aa)
	HPX	Uncharacterized protein. (228 aa)
	AMN	Amnion associated transmembrane protein. (492 aa)
	MMAB	Corrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (210 aa)
	LOC102364057	Zgc:101765. (284 aa)
	EIF2AK1	Eukaryotic translation initiation factor 2 alpha kinase 1. (580 aa)
	MMAA	Metabolism of cobalamin associated A. (424 aa)
	UROD	Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. (370 aa)
	MMADHC	Metabolism of cobalamin associated D. (311 aa)
	PGRMC1	Progesterone receptor membrane component 1; Belongs to the cytochrome b5 family. (179 aa)
	PHYHIPL	Phytanoyl-CoA 2-hydroxylase interacting protein like. (331 aa)
	ALAS2	5-aminolevulinate synthase. (615 aa)
	RSAD1	Radical S-adenosyl methionine domain-containing protein; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (452 aa)
	MMACHC	Metabolism of cobalamin associated C. (242 aa)
	FXN	Frataxin. (194 aa)
	CPOX	Coproporphyrinogen oxidase. (449 aa)
	MTR	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1252 aa)
	PHYHIP	Phytanoyl-CoA 2-hydroxylase interacting protein. (334 aa)
	ALAD	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (330 aa)
	FECH	Ferrochelatase; Belongs to the ferrochelatase family. (410 aa)
	HMBS	Hydroxymethylbilane synthase. (368 aa)
	ALAS1	5-aminolevulinate synthase. (642 aa)
	ABCD4	ATP-binding cassette, sub-family D (ALD), member 4. (438 aa)
	COX10	Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family. (441 aa)
	ABCB6	ATP binding cassette subfamily B member 6 (Langereis blood group). (776 aa)
	BLVRB	Biliverdin reductase B. (211 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCB10	ABCB6	ENSLACP00000004829	ENSLACP00000020225	ATP binding cassette subfamily B member 10.	ATP binding cassette subfamily B member 6 (Langereis blood group).	0.518
ABCB10	ALAD	ENSLACP00000004829	ENSLACP00000019000	ATP binding cassette subfamily B member 10.	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	0.453
ABCB10	COX10	ENSLACP00000004829	ENSLACP00000020317	ATP binding cassette subfamily B member 10.	Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family.	0.774
ABCB10	FECH	ENSLACP00000004829	ENSLACP00000019117	ATP binding cassette subfamily B member 10.	Ferrochelatase; Belongs to the ferrochelatase family.	0.708
ABCB10	PPOX	ENSLACP00000004829	ENSLACP00000004365	ATP binding cassette subfamily B member 10.	Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.	0.403
ABCB6	ABCB10	ENSLACP00000020225	ENSLACP00000004829	ATP binding cassette subfamily B member 6 (Langereis blood group).	ATP binding cassette subfamily B member 10.	0.518
ABCB6	ABCD4	ENSLACP00000020225	ENSLACP00000021089	ATP binding cassette subfamily B member 6 (Langereis blood group).	ATP-binding cassette, sub-family D (ALD), member 4.	0.492
ABCB6	ALAD	ENSLACP00000020225	ENSLACP00000019000	ATP binding cassette subfamily B member 6 (Langereis blood group).	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	0.477
ABCB6	CPOX	ENSLACP00000020225	ENSLACP00000018040	ATP binding cassette subfamily B member 6 (Langereis blood group).	Coproporphyrinogen oxidase.	0.447
ABCB6	FECH	ENSLACP00000020225	ENSLACP00000019117	ATP binding cassette subfamily B member 6 (Langereis blood group).	Ferrochelatase; Belongs to the ferrochelatase family.	0.650
ABCB6	FXN	ENSLACP00000020225	ENSLACP00000017270	ATP binding cassette subfamily B member 6 (Langereis blood group).	Frataxin.	0.554
ABCB6	PPOX	ENSLACP00000020225	ENSLACP00000004365	ATP binding cassette subfamily B member 6 (Langereis blood group).	Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.	0.618
ABCB6	UROD	ENSLACP00000020225	ENSLACP00000012251	ATP binding cassette subfamily B member 6 (Langereis blood group).	Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family.	0.497
ABCB6	UROS	ENSLACP00000020225	ENSLACP00000004564	ATP binding cassette subfamily B member 6 (Langereis blood group).	Uroporphyrinogen III synthase.	0.602
ABCD4	ABCB6	ENSLACP00000021089	ENSLACP00000020225	ATP-binding cassette, sub-family D (ALD), member 4.	ATP binding cassette subfamily B member 6 (Langereis blood group).	0.492
ABCD4	MMACHC	ENSLACP00000021089	ENSLACP00000017044	ATP-binding cassette, sub-family D (ALD), member 4.	Metabolism of cobalamin associated C.	0.420
ABCD4	MTR	ENSLACP00000021089	ENSLACP00000018670	ATP-binding cassette, sub-family D (ALD), member 4.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.409
ALAD	ABCB10	ENSLACP00000019000	ENSLACP00000004829	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	ATP binding cassette subfamily B member 10.	0.453
ALAD	ABCB6	ENSLACP00000019000	ENSLACP00000020225	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	ATP binding cassette subfamily B member 6 (Langereis blood group).	0.477
ALAD	ALAS1	ENSLACP00000019000	ENSLACP00000021401	Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.	5-aminolevulinate synthase.	0.981