(9 nodes) Leptin-mediated signaling pathway network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	SIRT1	Sirtuin 1. (729 aa)
	LEPR	Leptin receptor. (1149 aa)
	EBI3	Epstein-Barr virus induced 3. (290 aa)
	MKKS	McKusick-Kaufman syndrome. (575 aa)
	BBS4	Bardet-Biedl syndrome 4. (537 aa)
	UGCG	UDP-glucose ceramide glucosyltransferase. (394 aa)
	BBS2	Bardet-Biedl syndrome 2 protein homolog. (724 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BBS2	BBS4	ENSLACP00000017026	ENSLACP00000002102	Bardet-Biedl syndrome 2 protein homolog.	Bardet-Biedl syndrome 4.	0.998
BBS2	MKKS	ENSLACP00000017026	ENSLACP00000006659	Bardet-Biedl syndrome 2 protein homolog.	McKusick-Kaufman syndrome.	0.427
BBS4	BBS2	ENSLACP00000002102	ENSLACP00000017026	Bardet-Biedl syndrome 4.	Bardet-Biedl syndrome 2 protein homolog.	0.998
EBI3	STAT3	ENSLACP00000007914	ENSLACP00000013656	Epstein-Barr virus induced 3.	Signal transducer and activator of transcription.	0.409
LEP	LEPR	ENSLACP00000011398	ENSLACP00000008593	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Leptin receptor.	0.936
LEP	STAT3	ENSLACP00000011398	ENSLACP00000013656	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Signal transducer and activator of transcription.	0.726
LEPR	LEP	ENSLACP00000008593	ENSLACP00000011398	Leptin receptor.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.936
LEPR	STAT3	ENSLACP00000008593	ENSLACP00000013656	Leptin receptor.	Signal transducer and activator of transcription.	0.722
MKKS	BBS2	ENSLACP00000006659	ENSLACP00000017026	McKusick-Kaufman syndrome.	Bardet-Biedl syndrome 2 protein homolog.	0.427
SIRT1	STAT3	ENSLACP00000009079	ENSLACP00000013656	Sirtuin 1.	Signal transducer and activator of transcription.	0.535
STAT3	EBI3	ENSLACP00000013656	ENSLACP00000007914	Signal transducer and activator of transcription.	Epstein-Barr virus induced 3.	0.409
STAT3	LEP	ENSLACP00000013656	ENSLACP00000011398	Signal transducer and activator of transcription.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.726
STAT3	LEPR	ENSLACP00000013656	ENSLACP00000008593	Signal transducer and activator of transcription.	Leptin receptor.	0.722
STAT3	SIRT1	ENSLACP00000013656	ENSLACP00000009079	Signal transducer and activator of transcription.	Sirtuin 1.	0.535