(30 nodes) Regulation of tissue remodeling network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	MC4R	Melanocortin 4 receptor. (329 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (210 aa)
	SIGLEC15	Sialic acid binding Ig like lectin 15. (265 aa)
	PLEKHM1	Pleckstrin homology and RUN domain containing M1. (1054 aa)
	TNFRSF11B	TNF receptor superfamily member 11b. (409 aa)
	GREM1	Gremlin 1, DAN family BMP antagonist. (189 aa)
	TMEM64	Transmembrane protein 64. (350 aa)
	DEF8	Differentially expressed in FDCP 8 homolog. (450 aa)
	LEPR	Leptin receptor. (1149 aa)
	LOC102348760	Uncharacterized protein. (782 aa)
	LOC102355441	Cocaine- and amphetamine-regulated transcript 3. (119 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (169 aa)
	H3AM01_LATCH	Integrin beta; Belongs to the integrin beta chain family. (769 aa)
	SYT7	Synaptotagmin 7. (286 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	GPR137B	G protein-coupled receptor 137B. (349 aa)
	PPARGC1B	PPARG coactivator 1 beta. (986 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (838 aa)
	GPNMB	Glycoprotein nmb. (607 aa)
	INPP5D	Inositol polyphosphate-5-phosphatase D. (1144 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1350 aa)
	CSF1R	Colony stimulating factor 1 receptor. (968 aa)
	SUCO	SUN domain containing ossification factor. (1247 aa)
	NF1	Neurofibromin 1. (2814 aa)
	MDK	Midkine. (141 aa)
	UBASH3B	Ubiquitin associated and SH3 domain containing B. (607 aa)
	IL18	Uncharacterized protein. (200 aa)
	FLT4	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1394 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSF1R	TNFSF11	ENSLACP00000016266	ENSLACP00000009224	Colony stimulating factor 1 receptor.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.706
DEF8	INPP5D	ENSLACP00000007647	ENSLACP00000014830	Differentially expressed in FDCP 8 homolog.	Inositol polyphosphate-5-phosphatase D.	0.517
DEF8	MC4R	ENSLACP00000007647	ENSLACP00000000487	Differentially expressed in FDCP 8 homolog.	Melanocortin 4 receptor.	0.508
FLT4	H3AM01_LATCH	ENSLACP00000022811	ENSLACP00000010672	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Integrin beta; Belongs to the integrin beta chain family.	0.448
H3AM01_LATCH	FLT4	ENSLACP00000010672	ENSLACP00000022811	Integrin beta; Belongs to the integrin beta chain family.	Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.448
H3AM01_LATCH	ROCK1	ENSLACP00000010672	ENSLACP00000016034	Integrin beta; Belongs to the integrin beta chain family.	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.618
H3AM01_LATCH	SYK	ENSLACP00000010672	ENSLACP00000012982	Integrin beta; Belongs to the integrin beta chain family.	Tyrosine-protein kinase.	0.703
INPP5D	DEF8	ENSLACP00000014830	ENSLACP00000007647	Inositol polyphosphate-5-phosphatase D.	Differentially expressed in FDCP 8 homolog.	0.517
LEP	LEPR	ENSLACP00000011398	ENSLACP00000008593	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Leptin receptor.	0.936
LEP	LOC102355441	ENSLACP00000011398	ENSLACP00000009134	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Cocaine- and amphetamine-regulated transcript 3.	0.480
LEP	MC4R	ENSLACP00000011398	ENSLACP00000000487	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Melanocortin 4 receptor.	0.745
LEP	TP53	ENSLACP00000011398	ENSLACP00000015915	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.420
LEPR	LEP	ENSLACP00000008593	ENSLACP00000011398	Leptin receptor.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.936
LEPR	LOC102355441	ENSLACP00000008593	ENSLACP00000009134	Leptin receptor.	Cocaine- and amphetamine-regulated transcript 3.	0.481
LEPR	MC4R	ENSLACP00000008593	ENSLACP00000000487	Leptin receptor.	Melanocortin 4 receptor.	0.714
LOC102355441	LEP	ENSLACP00000009134	ENSLACP00000011398	Cocaine- and amphetamine-regulated transcript 3.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.480
LOC102355441	LEPR	ENSLACP00000009134	ENSLACP00000008593	Cocaine- and amphetamine-regulated transcript 3.	Leptin receptor.	0.481
MC4R	DEF8	ENSLACP00000000487	ENSLACP00000007647	Melanocortin 4 receptor.	Differentially expressed in FDCP 8 homolog.	0.508
MC4R	LEP	ENSLACP00000000487	ENSLACP00000011398	Melanocortin 4 receptor.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.745
MC4R	LEPR	ENSLACP00000000487	ENSLACP00000008593	Melanocortin 4 receptor.	Leptin receptor.	0.714