(43 nodes) Response to interferon-gamma network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZYX	Zyxin. (554 aa)
	H2ZS93_LATCH	GB1/RHD3-type G domain-containing protein. (357 aa)
	H2ZVR1_LATCH	Uncharacterized protein. (167 aa)
	IRF1	Interferon regulatory factor. (264 aa)
	VPS26B	VPS26, retromer complex component B. (194 aa)
	NMI	N-myc and STAT interactor. (372 aa)
	CD40	TNFR-Cys domain-containing protein. (167 aa)
	CIITA	Class II major histocompatibility complex transactivator. (793 aa)
	H3A7B9_LATCH	GB1/RHD3-type G domain-containing protein. (588 aa)
	H3A9Q8_LATCH	GB1/RHD3-type G domain-containing protein. (451 aa)
	LOC102351334	Scinderin like a. (721 aa)
	AQP4	Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (319 aa)
	HPX	Uncharacterized protein. (228 aa)
	NUB1	Negative regulator of ubiquitin like proteins 1. (601 aa)
	H3ALK3_LATCH	GB1/RHD3-type G domain-containing protein. (424 aa)
	MYO1C	Myosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1036 aa)
	MRC1	Mannose receptor C-type 1. (1458 aa)
	STX8	Syntaxin 8. (235 aa)
	CDC42EP2	CDC42 effector protein 2. (259 aa)
	LOC102359447	GTP cyclohydrolase 2. (241 aa)
	VAMP3	Vesicle associated membrane protein 3. (138 aa)
	RAB20	RAB20, member RAS oncogene family. (235 aa)
	CITED1	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (165 aa)
	EPRS1	Glutamyl-prolyl-tRNA synthetase. (1965 aa)
	ADAMTS13	ADAM metallopeptidase with thrombospondin type 1 motif 13. (1330 aa)
	LOC102357099	GB1/RHD3-type G domain-containing protein. (487 aa)
	H3AZM6_LATCH	GB1/RHD3-type G domain-containing protein. (616 aa)
	LOC102352317	GB1/RHD3-type G domain-containing protein. (615 aa)
	LOC102352041	GB1/RHD3-type G domain-containing protein. (624 aa)
	STXBP4	Syntaxin binding protein 4. (703 aa)
	H3B0S3_LATCH	GB1/RHD3-type G domain-containing protein. (646 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
	RAB7B	RAB7B, member RAS oncogene family. (201 aa)
	STXBP3	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (597 aa)
	CLDN1	Claudin 1. (210 aa)
	PDE12	Phosphodiesterase 12. (587 aa)
	CD74	CD74 molecule. (279 aa)
	LOC102354684	Immunoresponsive gene 1, like. (506 aa)
	CDC42EP4	CDC42 effector protein 4. (321 aa)
	GCH1	GTP cyclohydrolase 1. (252 aa)
	LOC102352351	C-C motif chemokine. (88 aa)
	UBD	Uncharacterized protein. (163 aa)
	KYNU	Kynureninase. (278 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD74	CIITA	ENSLACP00000018188	ENSLACP00000004653	CD74 molecule.	Class II major histocompatibility complex transactivator.	0.619
CD74	EPRS1	ENSLACP00000018188	ENSLACP00000013372	CD74 molecule.	Glutamyl-prolyl-tRNA synthetase.	0.865
CD74	UBD	ENSLACP00000018188	ENSLACP00000022532	CD74 molecule.	Uncharacterized protein.	0.775
CDC42EP2	CDC42EP4	ENSLACP00000011990	ENSLACP00000021009	CDC42 effector protein 2.	CDC42 effector protein 4.	0.421
CDC42EP4	CDC42EP2	ENSLACP00000021009	ENSLACP00000011990	CDC42 effector protein 4.	CDC42 effector protein 2.	0.421
CIITA	CD74	ENSLACP00000004653	ENSLACP00000018188	Class II major histocompatibility complex transactivator.	CD74 molecule.	0.619
CIITA	IRF1	ENSLACP00000004653	ENSLACP00000001728	Class II major histocompatibility complex transactivator.	Interferon regulatory factor.	0.457
EPRS1	CD74	ENSLACP00000013372	ENSLACP00000018188	Glutamyl-prolyl-tRNA synthetase.	CD74 molecule.	0.865
EPRS1	GCH1	ENSLACP00000013372	ENSLACP00000021689	Glutamyl-prolyl-tRNA synthetase.	GTP cyclohydrolase 1.	0.695
EPRS1	LOC102359447	ENSLACP00000013372	ENSLACP00000012093	Glutamyl-prolyl-tRNA synthetase.	GTP cyclohydrolase 2.	0.695
EPRS1	UBD	ENSLACP00000013372	ENSLACP00000022532	Glutamyl-prolyl-tRNA synthetase.	Uncharacterized protein.	0.599
GCH1	EPRS1	ENSLACP00000021689	ENSLACP00000013372	GTP cyclohydrolase 1.	Glutamyl-prolyl-tRNA synthetase.	0.695
GCH1	LOC102359447	ENSLACP00000021689	ENSLACP00000012093	GTP cyclohydrolase 1.	GTP cyclohydrolase 2.	0.901
IRF1	CIITA	ENSLACP00000001728	ENSLACP00000004653	Interferon regulatory factor.	Class II major histocompatibility complex transactivator.	0.457
LOC102354684	UBD	ENSLACP00000020110	ENSLACP00000022532	Immunoresponsive gene 1, like.	Uncharacterized protein.	0.412
LOC102359447	EPRS1	ENSLACP00000012093	ENSLACP00000013372	GTP cyclohydrolase 2.	Glutamyl-prolyl-tRNA synthetase.	0.695
LOC102359447	GCH1	ENSLACP00000012093	ENSLACP00000021689	GTP cyclohydrolase 2.	GTP cyclohydrolase 1.	0.901
NUB1	UBD	ENSLACP00000010464	ENSLACP00000022532	Negative regulator of ubiquitin like proteins 1.	Uncharacterized protein.	0.841
RAB20	RAB7B	ENSLACP00000012485	ENSLACP00000016038	RAB20, member RAS oncogene family.	RAB7B, member RAS oncogene family.	0.449
RAB7B	RAB20	ENSLACP00000016038	ENSLACP00000012485	RAB7B, member RAS oncogene family.	RAB20, member RAS oncogene family.	0.449