(58 nodes) Cellular response to reactive oxygen species network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (625 aa)
	H2ZV40_LATCH	Protein kinase domain-containing protein. (266 aa)
	FABP1	Fatty acid binding protein 1. (98 aa)
	PRDX2	Peroxiredoxin 2. (109 aa)
	MAPK13	Mitogen-activated protein kinase. (162 aa)
	PPARGC1B	PPARG coactivator 1 beta. (986 aa)
	PDCD10	Programmed cell death 10. (210 aa)
	ANKZF1	Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1. (731 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (667 aa)
	LOC102350310	GBP domain-containing protein. (339 aa)
	IMPACT	Impact RWD domain protein. (319 aa)
	ROMO1	Reactive oxygen species modulator 1. (79 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (391 aa)
	SETX	Senataxin. (2165 aa)
	AXL	AXL receptor tyrosine kinase. (872 aa)
	PRDX5	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (190 aa)
	CCS	Copper chaperone for superoxide dismutase. (274 aa)
	NCF1	Neutrophil cytosolic factor 1. (416 aa)
	LOC102349421	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (528 aa)
	EDN1	Endothelin 1. (216 aa)
	LOC102362765	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (537 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (223 aa)
	FXN	Frataxin. (194 aa)
	PRDX3	Peroxiredoxin 3. (254 aa)
	TNFAIP3	TNF alpha induced protein 3. (785 aa)
	PRDX1	Peroxiredoxin 1. (127 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (365 aa)
	SOD1	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
	TRPM2	Transient receptor potential cation channel subfamily M member 2. (1473 aa)
	TRPA1	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1138 aa)
	MMP9	Matrix metallopeptidase 9. (682 aa)
	ECT2	Epithelial cell transforming 2. (919 aa)
	LOC102346566	Annexin. (343 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (590 aa)
	PARK7	Parkinsonism associated deglycase. (217 aa)
	IL6	Uncharacterized protein. (149 aa)
	NET1	Neuroepithelial cell transforming 1. (631 aa)
	ZNF277	Zinc finger protein 277. (443 aa)
	SIRT1	Sirtuin 1. (729 aa)
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (521 aa)
	PTPRK	Protein tyrosine phosphatase receptor type K. (565 aa)
	H3AEK5_LATCH	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
	KDM6B	Lysine demethylase 6B. (1638 aa)
	H3AD77_LATCH	JunE proto-oncogene, AP-1 transcription factor subunit. (316 aa)
	SOD3	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (234 aa)
	RPS3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (254 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (311 aa)
	PJVK	Pejvakin. (355 aa)
	SIGMAR1	Sigma non-opioid intracellular receptor 1. (223 aa)
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (927 aa)
	H3A2T1_LATCH	Uncharacterized protein. (573 aa)
	LOC102354290	Uncharacterized protein. (579 aa)
	H2ZZI1_LATCH	RING-type domain-containing protein. (424 aa)
	OSER1	Oxidative stress responsive serine rich 1. (298 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	H2ZWE3_LATCH	Uncharacterized protein. (222 aa)
	LOC102354262	Mitogen-activated protein kinase. (330 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (657 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIFM1	SOD2	ENSLACP00000001333	ENSLACP00000017629	Apoptosis inducing factor mitochondria associated 1.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.544
CAT	LOC102354290	ENSLACP00000008889	ENSLACP00000003364	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Uncharacterized protein.	0.744
CAT	PARK7	ENSLACP00000008889	ENSLACP00000009483	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Parkinsonism associated deglycase.	0.774
CAT	PRDX1	ENSLACP00000008889	ENSLACP00000016215	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Peroxiredoxin 1.	0.727
CAT	PRDX2	ENSLACP00000008889	ENSLACP00000000520	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Peroxiredoxin 2.	0.727
CAT	PRDX3	ENSLACP00000008889	ENSLACP00000016627	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Peroxiredoxin 3.	0.727
CAT	PRDX5	ENSLACP00000008889	ENSLACP00000020374	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily.	0.715
CAT	SOD1	ENSLACP00000008889	ENSLACP00000015602	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.956
CAT	SOD2	ENSLACP00000008889	ENSLACP00000017629	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.973
CAT	SOD3	ENSLACP00000008889	ENSLACP00000007003	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.956
CCS	FXN	ENSLACP00000020223	ENSLACP00000017270	Copper chaperone for superoxide dismutase.	Frataxin.	0.470
CCS	LOC102354290	ENSLACP00000020223	ENSLACP00000003364	Copper chaperone for superoxide dismutase.	Uncharacterized protein.	0.510
CCS	SOD1	ENSLACP00000020223	ENSLACP00000015602	Copper chaperone for superoxide dismutase.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.976
CCS	SOD2	ENSLACP00000020223	ENSLACP00000017629	Copper chaperone for superoxide dismutase.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.706
CCS	SOD3	ENSLACP00000020223	ENSLACP00000007003	Copper chaperone for superoxide dismutase.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.979
EDN1	IL6	ENSLACP00000018825	ENSLACP00000009318	Endothelin 1.	Uncharacterized protein.	0.531
FABP1	LOC102362765	ENSLACP00000000844	ENSLACP00000018641	Fatty acid binding protein 1.	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family.	0.427
FOS	H3AD77_LATCH	ENSLACP00000020665	ENSLACP00000007598	Fos proto-oncogene, AP-1 transcription factor subunit.	JunE proto-oncogene, AP-1 transcription factor subunit.	0.998
FOS	IL6	ENSLACP00000020665	ENSLACP00000009318	Fos proto-oncogene, AP-1 transcription factor subunit.	Uncharacterized protein.	0.572
FOS	JUN	ENSLACP00000020665	ENSLACP00000005596	Fos proto-oncogene, AP-1 transcription factor subunit.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.999