STRINGSTRING
HELZ2 HELZ2 EXOSC2 EXOSC2 ENTPD3 ENTPD3 PDE12 PDE12 ENDOG ENDOG H3B657_LATCH H3B657_LATCH UPB1 UPB1 LOC102363855 LOC102363855 EXOSC9 EXOSC9 H3B5R9_LATCH H3B5R9_LATCH LSM2 LSM2 ENPP4 ENPP4 DDX5 DDX5 LOC102348996 LOC102348996 NANOS2 NANOS2 ADA ADA LOC102360622 LOC102360622 ZPR1 ZPR1 LOC102364611 LOC102364611 PDE4B PDE4B DHX34 DHX34 PDE8B PDE8B PYM1 PYM1 DNASE1L2 DNASE1L2 RBM8A RBM8A TENT2 TENT2 EDC3 EDC3 METTL3 METTL3 SSB SSB LRPPRC LRPPRC NCBP1 NCBP1 DCP1A DCP1A H3B0V9_LATCH H3B0V9_LATCH DNA2 DNA2 ENTPD4 ENTPD4 FBH1 FBH1 CASC3 CASC3 NUDT19 NUDT19 ZFP36L2 ZFP36L2 TYMP TYMP DIS3L2 DIS3L2 MUS81 MUS81 NT5C1A NT5C1A H3AXI1_LATCH H3AXI1_LATCH EXOG EXOG FITM2 FITM2 POP1 POP1 REXO4 REXO4 CNOT11 CNOT11 MLYCD MLYCD ENTPD8 ENTPD8 RIDA RIDA EXOSC7 EXOSC7 CNOT10 CNOT10 ITPA ITPA H3AUF0_LATCH H3AUF0_LATCH SAMD4B SAMD4B H3ATP6_LATCH H3ATP6_LATCH GDA GDA DXO DXO DPYD DPYD DNPH1 DNPH1 PNPT1 PNPT1 ENTPD7 ENTPD7 LSM1 LSM1 CNOT1 CNOT1 RNASEH2B RNASEH2B TUT4 TUT4 SMG5 SMG5 NT5M NT5M ENTPD6 ENTPD6 PDE9A PDE9A RNASEH2C RNASEH2C MTPAP MTPAP LOC102354087 LOC102354087 TENT4B TENT4B TTC37 TTC37 CNOT3 CNOT3 MGAT1 MGAT1 TTC38 TTC38 NUDT13 NUDT13 NUDT3 NUDT3 H3AMJ7_LATCH H3AMJ7_LATCH EXOSC8 EXOSC8 CNOT7 CNOT7 AICDA AICDA H3ALI3_LATCH H3ALI3_LATCH EXOSC4 EXOSC4 H3ALC0_LATCH H3ALC0_LATCH SWT1 SWT1 B4GALNT3 B4GALNT3 MTREX MTREX NUDT15 NUDT15 XRN1 XRN1 NT5E NT5E ZCCHC7 ZCCHC7 LOC102361891 LOC102361891 TRIR TRIR SMPDL3A SMPDL3A UPF3B UPF3B APEX1 APEX1 DERA DERA SMG1 SMG1 UPF1 UPF1 SETMAR SETMAR NUDT4 NUDT4 LOC102358410 LOC102358410 XRN2 XRN2 DICER1 DICER1 CNP CNP H3AI59_LATCH H3AI59_LATCH LOC102367082 LOC102367082 SUPV3L1 SUPV3L1 EIF4A3 EIF4A3 H2ZRY7_LATCH H2ZRY7_LATCH DNASE2B DNASE2B CNOT8 CNOT8 RC3H2 RC3H2 PDE7A PDE7A DCP2 DCP2 H2ZTU8_LATCH H2ZTU8_LATCH TREX2 TREX2 SMG6 SMG6 SMG7 SMG7 ENPP3 ENPP3 FEN1 FEN1 TUT7 TUT7 DCPS DCPS ENPP1 ENPP1 ACAT1 ACAT1 NUDT9 NUDT9 LIN28A LIN28A UPP1 UPP1 H3A117_LATCH H3A117_LATCH SMG6-2 SMG6-2 ENTPD1 ENTPD1 NBAS NBAS H3A3Y9_LATCH H3A3Y9_LATCH EIF3E EIF3E LIN28B LIN28B LOC102354234 LOC102354234 PARN PARN H3A551_LATCH H3A551_LATCH ETF1 ETF1 LOC102362277 LOC102362277 LOC102349034 LOC102349034 PATL1 PATL1 CNOT6L CNOT6L ATM ATM PATL2 PATL2 PDE5A PDE5A LOC102357966 LOC102357966 EXOSC3 EXOSC3 NT5C NT5C PDE2A PDE2A POLR2G POLR2G SMG8 SMG8 H3ACR0_LATCH H3ACR0_LATCH DCTPP1 DCTPP1 UPF3A UPF3A SARM1 SARM1 LSM6 LSM6 CNOT2 CNOT2 RNASEH1 RNASEH1 CDA CDA PDE8A PDE8A THRAP3 THRAP3 DIS3 DIS3 LRRC27 LRRC27 ZFP36L1 ZFP36L1 MRTO4 MRTO4 DFFB DFFB SAMD4A SAMD4A H3BI75_LATCH H3BI75_LATCH ADAL ADAL PAN2 PAN2 H3BH75_LATCH H3BH75_LATCH LOC102357216 LOC102357216 WDR82 WDR82 ENTPD5 ENTPD5 SAMHD1 SAMHD1 EXOSC5 EXOSC5 AMPD3 AMPD3 METTL16 METTL16 PDE4D PDE4D CNOT9 CNOT9 NCBP2 NCBP2 ZC3H12A ZC3H12A DCP1B DCP1B NUDT17 NUDT17 POLR2D POLR2D PAN3 PAN3 NUDT18 NUDT18 AGO1 AGO1 ACOT7 ACOT7 AGO4 AGO4 EXOSC10 EXOSC10 NUDT1 NUDT1 EDC4 EDC4 LOC102364797 LOC102364797 ZHX2 ZHX2 CDADC1 CDADC1 RNASEH2A RNASEH2A MLH1 MLH1 DIS3L DIS3L RC3H1 RC3H1 PNRC2 PNRC2 ENTPD2 ENTPD2 APOBEC2 APOBEC2 LOC106701779 LOC106701779 DNASE1L1 DNASE1L1 UPF2 UPF2 H3B850_LATCH H3B850_LATCH H3B7Z9_LATCH H3B7Z9_LATCH NOCT NOCT LSM4 LSM4 SMG9 SMG9 H3B7I7_LATCH H3B7I7_LATCH LSM7 LSM7 H3B772_LATCH H3B772_LATCH NUDT12 NUDT12 B4GALNT4 B4GALNT4 H3B724_LATCH H3B724_LATCH
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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HELZ2Helicase with zinc finger 2. (2883 aa)
EXOSC2Exosome component 2. (293 aa)
ENTPD3Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (517 aa)
PDE12Phosphodiesterase 12. (587 aa)
ENDOGEndonuclease. (312 aa)
H3B657_LATCHSAM domain-containing protein. (189 aa)
UPB1Beta-ureidopropionase 1. (390 aa)
LOC102363855Uncharacterized protein. (351 aa)
EXOSC9Exosome component 9. (416 aa)
H3B5R9_LATCHNuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (156 aa)
LSM2U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)
ENPP4Ectonucleotide pyrophosphatase/phosphodiesterase 4. (456 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (512 aa)
LOC102348996Mago homolog, exon junction complex subunit. (148 aa)
NANOS2Nanos-type domain-containing protein; Belongs to the nanos family. (176 aa)
ADAA_deaminase domain-containing protein. (132 aa)
LOC102360622Phosphodiesterase. (504 aa)
ZPR1ZPR1 zinc finger. (470 aa)
LOC102364611Uncharacterized protein; Belongs to the RNase T2 family. (251 aa)
PDE4BPhosphodiesterase. (667 aa)
DHX34DExH-box helicase 34. (989 aa)
PDE8BPhosphodiesterase. (778 aa)
PYM1PYM homolog 1, exon junction complex associated factor. (215 aa)
DNASE1L2Deoxyribonuclease; Belongs to the DNase I family. (281 aa)
RBM8ARNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (177 aa)
TENT2Terminal nucleotidyltransferase 2. (496 aa)
EDC3Enhancer of mRNA decapping 3. (513 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
SSBSmall RNA binding exonuclease protection factor La. (409 aa)
LRPPRCLeucine-rich pentatricopeptide repeat containing. (1431 aa)
NCBP1Nuclear cap binding protein subunit 1. (804 aa)
DCP1ADecapping mRNA 1A. (597 aa)
H3B0V9_LATCHPhosphodiesterase. (538 aa)
DNA2DNA replication helicase/nuclease 2. (925 aa)
ENTPD4Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (481 aa)
FBH1F-box DNA helicase 1. (795 aa)
CASC3CASC3 exon junction complex subunit. (719 aa)
NUDT19Nudix hydrolase 19. (388 aa)
ZFP36L2Uncharacterized protein. (394 aa)
TYMPThymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (474 aa)
DIS3L2DIS3 like 3'-5' exoribonuclease 2. (698 aa)
MUS81Uncharacterized protein. (421 aa)
NT5C1A5'-nucleotidase, cytosolic IA. (371 aa)
H3AXI1_LATCHUncharacterized protein. (215 aa)
EXOGExo/endonuclease G. (370 aa)
FITM2Fat storage inducing transmembrane protein 2. (266 aa)
POP1POP1 homolog, ribonuclease P/MRP subunit. (966 aa)
REXO4REX4 homolog, 3'-5' exonuclease. (425 aa)
CNOT11CCR4-NOT transcription complex subunit 11. (445 aa)
MLYCDMalonyl-CoA decarboxylase. (480 aa)
ENTPD8Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (528 aa)
RIDAReactive intermediate imine deaminase A homolog. (137 aa)
EXOSC7Exosome component 7. (291 aa)
CNOT10CCR4-NOT transcription complex subunit 10. (751 aa)
ITPAInosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (192 aa)
H3AUF0_LATCHFibrinogen C-terminal domain-containing protein. (239 aa)
SAMD4BSterile alpha motif domain containing 4B. (653 aa)
H3ATP6_LATCHFibrinogen C-terminal domain-containing protein. (204 aa)
GDAGuanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (411 aa)
DXODecapping exoribonuclease. (413 aa)
DPYDPyr_redox_2 domain-containing protein. (333 aa)
DNPH12'-deoxynucleoside 5'-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. (134 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (724 aa)
ENTPD7Ectonucleoside triphosphate diphosphohydrolase 7; Belongs to the GDA1/CD39 NTPase family. (571 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (121 aa)
CNOT1CCR4-NOT transcription complex subunit 1. (2413 aa)
RNASEH2BRibonuclease H2 subunit B. (248 aa)
TUT4Terminal uridylyl transferase 4. (1706 aa)
SMG5SMG5 nonsense mediated mRNA decay factor. (1046 aa)
NT5M5',3'-nucleotidase, mitochondrial. (242 aa)
ENTPD6Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (425 aa)
PDE9APhosphodiesterase. (519 aa)
RNASEH2CUncharacterized protein. (142 aa)
MTPAPMitochondrial poly(A) polymerase. (474 aa)
LOC102354087SAM domain and HD domain 1. (617 aa)
TENT4BTerminal nucleotidyltransferase 4B. (682 aa)
TTC37Tetratricopeptide repeat domain 37. (1569 aa)
CNOT3CCR4-NOT transcription complex subunit 3. (727 aa)
MGAT1Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase. (445 aa)
TTC38Tetratricopeptide repeat domain 38. (470 aa)
NUDT13Nudix hydrolase 13. (341 aa)
NUDT3Nudix hydrolase 3. (214 aa)
H3AMJ7_LATCHNbas_N domain-containing protein. (373 aa)
EXOSC8Exosome component 8. (243 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (286 aa)
AICDAActivation-induced cytidine deaminase. (149 aa)
H3ALI3_LATCHUncharacterized protein. (187 aa)
EXOSC4Exosome component 4. (129 aa)
H3ALC0_LATCHUncharacterized protein. (630 aa)
SWT1SWT1 RNA endoribonuclease homolog. (696 aa)
B4GALNT3Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. (1066 aa)
MTREXMtr4 exosome RNA helicase. (1031 aa)
NUDT15Nudix hydrolase 15; Belongs to the Nudix hydrolase family. (165 aa)
XRN15'-3' exoribonuclease 1. (1737 aa)
NT5E5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (469 aa)
ZCCHC7Uncharacterized protein. (192 aa)
LOC102361891Zgc:194887. (292 aa)
TRIRTelomerase RNA component interacting RNase. (183 aa)
SMPDL3AAcid sphingomyelinase-like phosphodiesterase. (462 aa)
UPF3BUPF3B regulator of nonsense mediated mRNA decay. (470 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (314 aa)
DERADeoxyribose-phosphate aldolase. (320 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3451 aa)
UPF1UPF1 RNA helicase and ATPase. (697 aa)
SETMARSET domain and mariner transposase fusion gene. (198 aa)
NUDT4Nudix (nucleoside diphosphate linked moiety X)-type motif 4a. (181 aa)
LOC102358410IU_nuc_hydro domain-containing protein. (328 aa)
XRN25'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (921 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1923 aa)
CNP2',3'-cyclic nucleotide 3' phosphodiesterase. (423 aa)
H3AI59_LATCHA_deaminase domain-containing protein. (369 aa)
LOC102367082XPGI domain-containing protein. (317 aa)
SUPV3L1Suv3 like RNA helicase. (680 aa)
EIF4A3Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (406 aa)
H2ZRY7_LATCHUncharacterized protein. (69 aa)
DNASE2BDeoxyribonuclease 2 beta. (271 aa)
CNOT8CCR4-NOT transcription complex subunit 8. (210 aa)
RC3H2RING-type domain-containing protein. (352 aa)
PDE7APhosphodiesterase. (421 aa)
DCP2Decapping mRNA 2. (402 aa)
H2ZTU8_LATCHUncharacterized protein. (60 aa)
TREX2Exonuclease domain-containing protein. (242 aa)
SMG6SMG6 nonsense mediated mRNA decay factor. (803 aa)
SMG7SMG7 nonsense mediated mRNA decay factor. (1197 aa)
ENPP3Ectonucleotide pyrophosphatase/phosphodiesterase 3. (721 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (317 aa)
TUT7Terminal uridylyl transferase 7. (1545 aa)
DCPSDecapping enzyme, scavenger. (174 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (850 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (422 aa)
NUDT9Nudix hydrolase 9. (298 aa)
LIN28ALin-28 homolog A. (205 aa)
UPP1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (313 aa)
H3A117_LATCHHelicase ATP-binding domain-containing protein. (1175 aa)
SMG6-2PINc domain-containing protein. (465 aa)
ENTPD1Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (503 aa)
NBASNeuroblastoma amplified sequence. (1381 aa)
H3A3Y9_LATCHUncharacterized protein. (319 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (446 aa)
LIN28BLin-28 homolog B. (279 aa)
LOC102354234Phosphodiesterase. (711 aa)
PARNPoly(A)-specific ribonuclease. (529 aa)
H3A551_LATCHPhosphodiesterase. (437 aa)
ETF1Eukaryotic translation termination factor 1. (437 aa)
LOC102362277Uncharacterized protein; Belongs to the 5'-nucleotidase family. (541 aa)
LOC102349034Deoxyribonuclease; Belongs to the DNase I family. (312 aa)
PATL1PAT1 homolog 1, processing body mRNA decay factor. (723 aa)
CNOT6LCCR4-NOT transcription complex subunit 6 like. (553 aa)
ATMATM serine/threonine kinase. (2375 aa)
PATL2PAT1 domain-containing protein. (758 aa)
PDE5APhosphodiesterase. (722 aa)
LOC102357966Si:dkey-4e7.3. (318 aa)
EXOSC3Exosome component 3. (244 aa)
NT5C5', 3'-nucleotidase, cytosolic. (199 aa)
PDE2APhosphodiesterase. (705 aa)
POLR2GRNA polymerase II subunit G. (172 aa)
SMG8SMG8 nonsense mediated mRNA decay factor. (913 aa)
H3ACR0_LATCHUncharacterized protein. (151 aa)
DCTPP1dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. (155 aa)
UPF3AUPF3A regulator of nonsense mediated mRNA decay. (332 aa)
SARM1Sterile alpha and TIR motif containing 1. (715 aa)
LSM6LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated. (80 aa)
CNOT2CCR4-NOT transcription complex subunit 2. (534 aa)
RNASEH1Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (310 aa)
CDACytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (145 aa)
PDE8APhosphodiesterase. (808 aa)
THRAP3Thyroid hormone receptor associated protein 3. (982 aa)
DIS3DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (959 aa)
LRRC27Uncharacterized protein. (542 aa)
ZFP36L1ZFP36 ring finger protein like 1. (346 aa)
MRTO4Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (238 aa)
DFFBDNA fragmentation factor subunit beta. (349 aa)
SAMD4ASterile alpha motif domain containing 4A. (705 aa)
H3BI75_LATCHUncharacterized protein. (110 aa)
ADALAdenosine deaminase like. (358 aa)
PAN2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1224 aa)
H3BH75_LATCHUncharacterized protein. (421 aa)
LOC102357216Uncharacterized protein. (897 aa)
WDR82WD repeat domain 82. (603 aa)
ENTPD5Ectonucleoside triphosphate diphosphohydrolase 5 (inactive); Belongs to the GDA1/CD39 NTPase family. (431 aa)
SAMHD1Uncharacterized protein. (621 aa)
EXOSC5Exosome component 5. (198 aa)
AMPD3AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (773 aa)
METTL16U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (592 aa)
PDE4DPhosphodiesterase. (578 aa)
CNOT9CCR4-NOT transcription complex subunit 9. (299 aa)
NCBP2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (164 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (600 aa)
DCP1BDecapping mRNA 1B. (600 aa)
NUDT17Nudix hydrolase 17. (292 aa)
POLR2DRNA polymerase II subunit D. (142 aa)
PAN3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (841 aa)
NUDT18Nudix hydrolase 18; Belongs to the Nudix hydrolase family. (324 aa)
AGO1Argonaute RISC component 1; Belongs to the argonaute family. (852 aa)
ACOT7Acyl-CoA thioesterase 7. (318 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (861 aa)
EXOSC10Exosome component 10. (910 aa)
NUDT1Nudix hydrolase 1. (107 aa)
EDC4Enhancer of mRNA decapping 4. (1406 aa)
LOC102364797Uncharacterized protein. (299 aa)
ZHX2Zinc fingers and homeoboxes 2. (828 aa)
CDADC1Cytidine and dCMP deaminase domain containing 1. (485 aa)
RNASEH2ARibonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (249 aa)
MLH1MutL homolog 1. (821 aa)
DIS3LDIS3 like exosome 3'-5' exoribonuclease. (1060 aa)
RC3H1Ring finger and CCCH-type domains 1. (1123 aa)
PNRC2Proline rich nuclear receptor coactivator 2. (143 aa)
ENTPD2Ectonucleoside triphosphate diphosphohydrolase 2b; Belongs to the GDA1/CD39 NTPase family. (500 aa)
APOBEC2Apolipoprotein B mRNA editing enzyme catalytic subunit 2. (230 aa)
LOC106701779Uncharacterized protein. (373 aa)
DNASE1L1Deoxyribonuclease; Belongs to the DNase I family. (288 aa)
UPF2UPF2 regulator of nonsense mediated mRNA decay. (1273 aa)
H3B850_LATCHUncharacterized protein. (107 aa)
H3B7Z9_LATCHUncharacterized protein. (344 aa)
NOCTNocturnin. (446 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (140 aa)
SMG9SMG9 nonsense mediated mRNA decay factor. (519 aa)
H3B7I7_LATCHSb:cb81. (360 aa)
LSM7LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (103 aa)
H3B772_LATCHDeoxyribonuclease; Belongs to the DNase I family. (268 aa)
NUDT12Nudix hydrolase 12. (460 aa)
B4GALNT4Hexosyltransferase. (1011 aa)
H3B724_LATCHUncharacterized protein. (91 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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