(16 nodes) Regulation of Rac protein signal transduction network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1077 aa)
	ARF6	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
	STMN3	Stathmin; Belongs to the stathmin family. (180 aa)
	H3ADH9_LATCH	Rho-GAP domain-containing protein. (261 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
	AUTS2	Activator of transcription and developmental regulator AUTS2. (1021 aa)
	ARHGAP24	Rho GTPase activating protein 24. (653 aa)
	KBTBD7	Kelch repeat and BTB (POZ) domain containing 7. (643 aa)
	LOC102362971	Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1081 aa)
	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase. (1048 aa)
	ARHGAP17	Rho GTPase activating protein 17. (873 aa)
	CADM4	Cell adhesion molecule 4. (380 aa)
	ARHGAP44	Rho GTPase activating protein 44. (824 aa)
	SSX2IP	SSX family member 2 interacting protein. (495 aa)
	NF1	Neurofibromin 1. (2814 aa)
	LOC102349333	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (176 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARF6	LOC102349333	ENSLACP00000005263	ENSLACP00000021262	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.900
KBTBD7	NF1	ENSLACP00000011813	ENSLACP00000019331	Kelch repeat and BTB (POZ) domain containing 7.	Neurofibromin 1.	0.439
LOC102349333	ARF6	ENSLACP00000021262	ENSLACP00000005263	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	0.900
LOC102362971	PIK3CB	ENSLACP00000012857	ENSLACP00000014968	Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.696
LOC102362971	PIK3CG	ENSLACP00000012857	ENSLACP00000007893	Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.	0.902
NF1	KBTBD7	ENSLACP00000019331	ENSLACP00000011813	Neurofibromin 1.	Kelch repeat and BTB (POZ) domain containing 7.	0.439
PIK3CB	LOC102362971	ENSLACP00000014968	ENSLACP00000012857	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family.	0.696
PIK3CB	PIK3CG	ENSLACP00000014968	ENSLACP00000007893	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.	0.675
PIK3CG	LOC102362971	ENSLACP00000007893	ENSLACP00000012857	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.	Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family.	0.902
PIK3CG	PIK3CB	ENSLACP00000007893	ENSLACP00000014968	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.675