(56 nodes) Organ growth network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (463 aa)
	H3BFZ2_LATCH	BHLH domain-containing protein. (165 aa)
	H3BFW7_LATCH	BHLH domain-containing protein. (161 aa)
	WNT2B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	ANXA6	Annexin. (662 aa)
	LOC102352268	Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
	OSTN	Osteocrin. (136 aa)
	RARG	Retinoic acid receptor gamma. (389 aa)
	H3B938_LATCH	Teneurin N-terminal domain-containing protein. (181 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
	H3B6N2_LATCH	Teneurin N-terminal domain-containing protein. (214 aa)
	FXN	Frataxin. (194 aa)
	AR	Androgen receptor. (412 aa)
	NKX2-5	NK2 homeobox 5. (296 aa)
	STC1	Stanniocalcin 1. (250 aa)
	AKAP13	PH domain-containing protein. (644 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (907 aa)
	H3B181_LATCH	Teneurin transmembrane protein 4. (1031 aa)
	MMP13	Matrix metallopeptidase 13. (467 aa)
	SAV1	Salvador family WW domain containing protein 1. (393 aa)
	ARX	Aristaless related homeobox. (455 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (838 aa)
	SMAD1	Mothers against decapentaplegic homolog. (465 aa)
	IFT80	Intraflagellar transport 80. (780 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	IER3IP1	Immediate early response 3 interacting protein 1. (82 aa)
	HLX	H2.0 like homeobox. (384 aa)
	PDLIM5	PDZ and LIM domain 5. (629 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	LOC102364365	Natriuretic peptide A-like. (130 aa)
	THBS3	Thrombospondin 3. (930 aa)
	LOC106703556	Natriuretic peptide A-like. (129 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (906 aa)
	DLL3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (699 aa)
	LOC102348760	Uncharacterized protein. (782 aa)
	LEPR	Leptin receptor. (1149 aa)
	ECM1	Uncharacterized protein. (366 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (453 aa)
	RARB	NR LBD domain-containing protein. (299 aa)
	EVC	EvC ciliary complex subunit 1. (814 aa)
	RARA	Retinoic acid receptor alpha. (505 aa)
	ARID2	AT-rich interaction domain 2. (1771 aa)
	RAG2	Recombination activating 2. (522 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
	DIPK2A	Divergent protein kinase domain 2A. (434 aa)
	BNC2	Basonuclin 2. (880 aa)
	CER1	CTCK domain-containing protein. (257 aa)
	GATA6	GATA binding protein 6. (503 aa)
	ADRA1A	Adrenoceptor alpha 1A. (459 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (657 aa)
	LOC102356233	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (574 aa)
	BNC2-2	Uncharacterized protein. (124 aa)
	TMEM38B	Transmembrane protein 38B. (302 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA6	THBS3	ENSLACP00000019578	ENSLACP00000009179	Annexin.	Thrombospondin 3.	0.408
AR	LEP	ENSLACP00000017054	ENSLACP00000011398	Androgen receptor.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.563
BNC2	BNC2-2	ENSLACP00000003888	ENSLACP00000023198	Basonuclin 2.	Uncharacterized protein.	0.900
BNC2-2	BNC2	ENSLACP00000023198	ENSLACP00000003888	Uncharacterized protein.	Basonuclin 2.	0.900
CER1	WNT2	ENSLACP00000003380	ENSLACP00000017997	CTCK domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.652
CER1	WNT2B	ENSLACP00000003380	ENSLACP00000020566	CTCK domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.652
DLL1	DLL3	ENSLACP00000009351	ENSLACP00000008690	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
DLL3	DLL1	ENSLACP00000008690	ENSLACP00000009351	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.904
FGF7	FGF8	ENSLACP00000016167	ENSLACP00000007843	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.535
FGF8	FGF7	ENSLACP00000007843	ENSLACP00000016167	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.535
FGF8	NKX2-5	ENSLACP00000007843	ENSLACP00000016921	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	NK2 homeobox 5.	0.426
GATA6	NKX2-5	ENSLACP00000002849	ENSLACP00000016921	GATA binding protein 6.	NK2 homeobox 5.	0.814
H3B181_LATCH	H3B6N2_LATCH	ENSLACP00000015652	ENSLACP00000017553	Teneurin transmembrane protein 4.	Teneurin N-terminal domain-containing protein.	0.900
H3B181_LATCH	H3B938_LATCH	ENSLACP00000015652	ENSLACP00000018409	Teneurin transmembrane protein 4.	Teneurin N-terminal domain-containing protein.	0.900
H3B6N2_LATCH	H3B181_LATCH	ENSLACP00000017553	ENSLACP00000015652	Teneurin N-terminal domain-containing protein.	Teneurin transmembrane protein 4.	0.900
H3B6N2_LATCH	H3B938_LATCH	ENSLACP00000017553	ENSLACP00000018409	Teneurin N-terminal domain-containing protein.	Teneurin N-terminal domain-containing protein.	0.942
H3B938_LATCH	H3B181_LATCH	ENSLACP00000018409	ENSLACP00000015652	Teneurin N-terminal domain-containing protein.	Teneurin transmembrane protein 4.	0.900
H3B938_LATCH	H3B6N2_LATCH	ENSLACP00000018409	ENSLACP00000017553	Teneurin N-terminal domain-containing protein.	Teneurin N-terminal domain-containing protein.	0.942
LEP	AR	ENSLACP00000011398	ENSLACP00000017054	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Androgen receptor.	0.563
LEP	LEPR	ENSLACP00000011398	ENSLACP00000008593	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	Leptin receptor.	0.936