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LOC102355203 LOC102355203 H2ZUL4_LATCH H2ZUL4_LATCH LOC102357052 LOC102357052 ABCC9 ABCC9 GJA5 GJA5 CACNG2 CACNG2 NTRK2 NTRK2 LOC102351831 LOC102351831 SCN10A SCN10A LOC102353246 LOC102353246 KCNE4 KCNE4 P2RX3 P2RX3 KCNE3 KCNE3 CXADR CXADR SCN1B SCN1B MAG MAG JUP JUP CACNG8 CACNG8 ZMPSTE24 ZMPSTE24 CACNA1G CACNA1G CACNG7 CACNG7 GPER1 GPER1 SCN2A SCN2A H3AG91_LATCH H3AG91_LATCH CACNA1I CACNA1I H3AHJ4_LATCH H3AHJ4_LATCH KCNQ1 KCNQ1 CACNG5 CACNG5 SCN4A SCN4A CACNG4 CACNG4 FPGT FPGT SCN3B SCN3B NUP155 NUP155 GJD2 GJD2 JAM3 JAM3 DMRT3 DMRT3 GJC1 GJC1 CACNB4 CACNB4 KCNE2 KCNE2 OTOA OTOA KCNE1 KCNE1 POPDC2 POPDC2 NFASC NFASC LOC102353803 LOC102353803 H3B867_LATCH H3B867_LATCH H3B8U3_LATCH H3B8U3_LATCH MTOR MTOR LOC102356063 LOC102356063 CLDN19 CLDN19 LOC102366134 LOC102366134 CAV3 CAV3 P2RX1 P2RX1 SCN4B SCN4B SCN2B SCN2B SCN8A SCN8A P2RX4 P2RX4 PKP2 PKP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102355203Na_H_Exchanger domain-containing protein. (161 aa)
H2ZUL4_LATCHUncharacterized protein. (1374 aa)
LOC102357052Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (619 aa)
ABCC9ATP binding cassette subfamily C member 9. (1555 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (371 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (225 aa)
NTRK2Tyrosine-protein kinase receptor. (819 aa)
LOC102351831Nucleoporin 155. (1004 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1202 aa)
LOC102353246Uncharacterized protein. (374 aa)
KCNE4Potassium voltage-gated channel subfamily E regulatory subunit 4. (167 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
KCNE3Uncharacterized protein. (92 aa)
CXADRCXADR Ig-like cell adhesion molecule. (297 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (221 aa)
MAGMyelin associated glycoprotein. (633 aa)
JUPJunction plakoglobin. (694 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (367 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (453 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2282 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (302 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
SCN2ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1702 aa)
H3AG91_LATCHUncharacterized protein. (537 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (1831 aa)
H3AHJ4_LATCHIon_trans domain-containing protein; Belongs to the potassium channel family. (298 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (351 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
SCN4ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1836 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (329 aa)
FPGTTNNI3 interacting kinase. (938 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (216 aa)
NUP155Nucleoporin_C domain-containing protein. (385 aa)
GJD2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (304 aa)
JAM3Junctional adhesion molecule 3. (208 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (484 aa)
GJC1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (390 aa)
CACNB4Calcium channel, voltage-dependent, beta 4a subunit. (477 aa)
KCNE2Potassium voltage-gated channel subfamily E regulatory subunit 2. (125 aa)
OTOAOtoancorin. (997 aa)
KCNE1Uncharacterized protein. (122 aa)
POPDC2Popeye domain containing 2. (366 aa)
NFASCNeurofascin. (1339 aa)
LOC102353803Zgc:162160. (421 aa)
H3B867_LATCHSi:ch211-247n2.1. (233 aa)
H3B8U3_LATCHSerine/threonine-protein kinase TOR. (1418 aa)
MTORMechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
LOC102356063Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (554 aa)
CLDN19Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
LOC102366134Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (300 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (153 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (403 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (210 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (215 aa)
SCN8ASodium voltage-gated channel alpha subunit 8. (1587 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (391 aa)
PKP2Uncharacterized protein. (815 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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