(22 nodes) Positive regulation of mitochondrial membrane permeability network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	LOC102355203	Na_H_Exchanger domain-containing protein. (161 aa)
	RHOT2	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (589 aa)
	LOC102362386	Uncharacterized protein. (214 aa)
	EYA2	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (579 aa)
	LOC102354722	Uncharacterized protein. (116 aa)
	BAX	Uncharacterized protein. (223 aa)
	GSK3A	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (463 aa)
	LOC102362582	Uncharacterized protein. (213 aa)
	VDAC2	Voltage dependent anion channel 2. (313 aa)
	BOK	BCL2 family apoptosis regulator BOK. (111 aa)
	LOC102359041	Zgc:153993. (208 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
	BNIP3	BCL2 interacting protein 3. (202 aa)
	SPG7	SPG7 matrix AAA peptidase subunit, paraplegin. (663 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (401 aa)
	STPG1	Uncharacterized protein. (327 aa)
	BAK1	BCL2 antagonist/killer 1. (239 aa)
	RHOT1	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (673 aa)
	BNIP3L	BCL2 interacting protein 3 like. (208 aa)
	HIP1R	Huntingtin interacting protein 1 related. (1039 aa)
	M3XHJ5_LATCH	Uncharacterized protein. (158 aa)
	CFAP70	Cilia and flagella associated protein 70. (1141 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAK1	BAX	ENSLACP00000018296	ENSLACP00000007049	BCL2 antagonist/killer 1.	Uncharacterized protein.	0.985
BAK1	LOC102359041	ENSLACP00000018296	ENSLACP00000012675	BCL2 antagonist/killer 1.	Zgc:153993.	0.900
BAK1	M3XHJ5_LATCH	ENSLACP00000018296	ENSLACP00000022201	BCL2 antagonist/killer 1.	Uncharacterized protein.	0.934
BAK1	TP53	ENSLACP00000018296	ENSLACP00000015915	BCL2 antagonist/killer 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.787
BAX	BAK1	ENSLACP00000007049	ENSLACP00000018296	Uncharacterized protein.	BCL2 antagonist/killer 1.	0.985
BAX	LOC102359041	ENSLACP00000007049	ENSLACP00000012675	Uncharacterized protein.	Zgc:153993.	0.975
BAX	M3XHJ5_LATCH	ENSLACP00000007049	ENSLACP00000022201	Uncharacterized protein.	Uncharacterized protein.	0.912
BAX	TP53	ENSLACP00000007049	ENSLACP00000015915	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.780
BNIP3	BNIP3L	ENSLACP00000014880	ENSLACP00000020113	BCL2 interacting protein 3.	BCL2 interacting protein 3 like.	0.705
BNIP3	BOK	ENSLACP00000014880	ENSLACP00000009914	BCL2 interacting protein 3.	BCL2 family apoptosis regulator BOK.	0.471
BNIP3	LOC102354722	ENSLACP00000014880	ENSLACP00000003501	BCL2 interacting protein 3.	Uncharacterized protein.	0.901
BNIP3	TP53	ENSLACP00000014880	ENSLACP00000015915	BCL2 interacting protein 3.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.412
BNIP3L	BNIP3	ENSLACP00000020113	ENSLACP00000014880	BCL2 interacting protein 3 like.	BCL2 interacting protein 3.	0.705
BNIP3L	LOC102354722	ENSLACP00000020113	ENSLACP00000003501	BCL2 interacting protein 3 like.	Uncharacterized protein.	0.709
BNIP3L	TP53	ENSLACP00000020113	ENSLACP00000015915	BCL2 interacting protein 3 like.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.466
BOK	BNIP3	ENSLACP00000009914	ENSLACP00000014880	BCL2 family apoptosis regulator BOK.	BCL2 interacting protein 3.	0.471
BOK	LOC102354722	ENSLACP00000009914	ENSLACP00000003501	BCL2 family apoptosis regulator BOK.	Uncharacterized protein.	0.471
BOK	M3XHJ5_LATCH	ENSLACP00000009914	ENSLACP00000022201	BCL2 family apoptosis regulator BOK.	Uncharacterized protein.	0.765
CFAP70	VDAC2	ENSLACP00000023284	ENSLACP00000009820	Cilia and flagella associated protein 70.	Voltage dependent anion channel 2.	0.531
GSK3A	TP53	ENSLACP00000007367	ENSLACP00000015915	Glycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.555