STRINGSTRING
SUFU SUFU TAB1 TAB1 DCTN5 DCTN5 JAG1 JAG1 FKBP10 FKBP10 H3A007_LATCH H3A007_LATCH PKD2 PKD2 SMAD6 SMAD6 EDNRA EDNRA SEC24B SEC24B FGF8 FGF8 NPRL3 NPRL3 HECTD1 HECTD1 LEP LEP H3APB2_LATCH H3APB2_LATCH CNTRL CNTRL DLL4 DLL4 PLXND1 PLXND1 SRF SRF H3BCG1_LATCH H3BCG1_LATCH ACVRL1 ACVRL1 ENG ENG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SUFUSUFU negative regulator of hedgehog signaling. (422 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (436 aa)
DCTN5Dynactin subunit 5. (156 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
FKBP10Peptidylprolyl isomerase. (450 aa)
H3A007_LATCHUncharacterized protein. (52 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (890 aa)
SMAD6Mothers against decapentaplegic homolog. (485 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (424 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1197 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (396 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2580 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
H3APB2_LATCHFork-head domain-containing protein. (408 aa)
CNTRLCentriolin. (2273 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (688 aa)
PLXND1Plexin D1. (1875 aa)
SRFSerum response factor. (520 aa)
H3BCG1_LATCHSET domain-containing protein. (714 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (497 aa)
ENGEndoglin. (674 aa)
Your Current Organism:
Latimeria chalumnae
NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth
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