(21 nodes) NIK/NF-kappaB signaling network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL18R1	TIR domain-containing protein. (153 aa)
	H2ZV40_LATCH	Protein kinase domain-containing protein. (266 aa)
	H2ZVB4_LATCH	Uncharacterized protein. (436 aa)
	H2ZVZ2_LATCH	G_PROTEIN_RECEP_F1_2 domain-containing protein. (340 aa)
	H2ZXA8_LATCH	G_PROTEIN_RECEP_F1_2 domain-containing protein. (339 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (559 aa)
	MALT1	MALT1 paracaspase. (825 aa)
	CARD10	Caspase recruitment domain family member 10. (1063 aa)
	LOC102350947	G_PROTEIN_RECEP_F1_2 domain-containing protein. (327 aa)
	DICER1	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1923 aa)
	REL	REL proto-oncogene, NF-kB subunit. (593 aa)
	TRAF4	TNF receptor-associated factor. (434 aa)
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14. (940 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7. (580 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (673 aa)
	H3B0U4_LATCH	MALT paracaspase 2. (695 aa)
	H3B111_LATCH	V-rel avian reticuloendotheliosis viral oncogene homolog A. (203 aa)
	MAS1	G_PROTEIN_RECEP_F1_2 domain-containing protein. (309 aa)
	LOC102353021	Uncharacterized protein. (644 aa)
	TIRAP	TIR domain containing adaptor protein. (267 aa)
	IL18	Uncharacterized protein. (200 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARD10	H3B0U4_LATCH	ENSLACP00000004260	ENSLACP00000015515	Caspase recruitment domain family member 10.	MALT paracaspase 2.	0.583
CARD10	LOC102353021	ENSLACP00000004260	ENSLACP00000018014	Caspase recruitment domain family member 10.	Uncharacterized protein.	0.484
CARD10	MALT1	ENSLACP00000004260	ENSLACP00000004155	Caspase recruitment domain family member 10.	MALT1 paracaspase.	0.583
H2ZV40_LATCH	TRAF6	ENSLACP00000001261	ENSLACP00000003556	Protein kinase domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.656
H3B0U4_LATCH	CARD10	ENSLACP00000015515	ENSLACP00000004260	MALT paracaspase 2.	Caspase recruitment domain family member 10.	0.583
H3B0U4_LATCH	LOC102353021	ENSLACP00000015515	ENSLACP00000018014	MALT paracaspase 2.	Uncharacterized protein.	0.906
H3B0U4_LATCH	MALT1	ENSLACP00000015515	ENSLACP00000004155	MALT paracaspase 2.	MALT1 paracaspase.	0.902
H3B0U4_LATCH	MAP3K7	ENSLACP00000015515	ENSLACP00000011169	MALT paracaspase 2.	Mitogen-activated protein kinase kinase kinase 7.	0.606
H3B0U4_LATCH	TRAF6	ENSLACP00000015515	ENSLACP00000003556	MALT paracaspase 2.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.885
H3B111_LATCH	IRAK1	ENSLACP00000015582	ENSLACP00000014884	V-rel avian reticuloendotheliosis viral oncogene homolog A.	Interleukin 1 receptor associated kinase 1.	0.549
H3B111_LATCH	MAP3K14	ENSLACP00000015582	ENSLACP00000011006	V-rel avian reticuloendotheliosis viral oncogene homolog A.	Mitogen-activated protein kinase kinase kinase 14.	0.601
H3B111_LATCH	TRAF6	ENSLACP00000015582	ENSLACP00000003556	V-rel avian reticuloendotheliosis viral oncogene homolog A.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.556
IL18	IL18R1	ENSLACP00000021930	ENSLACP00000009449	Uncharacterized protein.	TIR domain-containing protein.	0.985
IL18	IRAK1	ENSLACP00000021930	ENSLACP00000014884	Uncharacterized protein.	Interleukin 1 receptor associated kinase 1.	0.470
IL18R1	IL18	ENSLACP00000009449	ENSLACP00000021930	TIR domain-containing protein.	Uncharacterized protein.	0.985
IRAK1	H3B111_LATCH	ENSLACP00000014884	ENSLACP00000015582	Interleukin 1 receptor associated kinase 1.	V-rel avian reticuloendotheliosis viral oncogene homolog A.	0.549
IRAK1	IL18	ENSLACP00000014884	ENSLACP00000021930	Interleukin 1 receptor associated kinase 1.	Uncharacterized protein.	0.470
IRAK1	MAP3K7	ENSLACP00000014884	ENSLACP00000011169	Interleukin 1 receptor associated kinase 1.	Mitogen-activated protein kinase kinase kinase 7.	0.801
IRAK1	REL	ENSLACP00000014884	ENSLACP00000009688	Interleukin 1 receptor associated kinase 1.	REL proto-oncogene, NF-kB subunit.	0.453
IRAK1	TIRAP	ENSLACP00000014884	ENSLACP00000020333	Interleukin 1 receptor associated kinase 1.	TIR domain containing adaptor protein.	0.815