(14 nodes) Nerve growth factor signaling pathway network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	LOC102345670	Sortilin. (809 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (272 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1217 aa)
	NTRK1	Tyrosine-protein kinase receptor. (747 aa)
	SORT1	Sortilin. (734 aa)
	H3B4C9_LATCH	PDZ domain-containing protein. (105 aa)
	MAGI2	Uncharacterized protein. (397 aa)
	BDNF	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (254 aa)
	RAPGEF2	Rap guanine nucleotide exchange factor 2. (1514 aa)
	H3AI06_LATCH	KAP NTPase domain-containing protein. (691 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (255 aa)
	NKPD1	NTPase, KAP family P-loop domain containing 1. (547 aa)
	NTF4	Neurotrophin 4; Belongs to the NGF-beta family. (232 aa)
	KIDINS220	Kinase D interacting substrate 220. (1774 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDNF	LOC102345670	ENSLACP00000012950	ENSLACP00000022200	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	Sortilin.	0.735
BDNF	NTF3	ENSLACP00000012950	ENSLACP00000007800	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.952
BDNF	NTF4	ENSLACP00000012950	ENSLACP00000005834	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	Neurotrophin 4; Belongs to the NGF-beta family.	0.967
BDNF	NTRK1	ENSLACP00000012950	ENSLACP00000017880	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	Tyrosine-protein kinase receptor.	0.960
BDNF	SORT1	ENSLACP00000012950	ENSLACP00000017653	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	Sortilin.	0.735
H3AI06_LATCH	H3B4C9_LATCH	ENSLACP00000009277	ENSLACP00000016750	KAP NTPase domain-containing protein.	PDZ domain-containing protein.	0.465
H3AI06_LATCH	MAGI2	ENSLACP00000009277	ENSLACP00000014418	KAP NTPase domain-containing protein.	Uncharacterized protein.	0.552
H3AI06_LATCH	NTRK1	ENSLACP00000009277	ENSLACP00000017880	KAP NTPase domain-containing protein.	Tyrosine-protein kinase receptor.	0.421
H3B4C9_LATCH	H3AI06_LATCH	ENSLACP00000016750	ENSLACP00000009277	PDZ domain-containing protein.	KAP NTPase domain-containing protein.	0.465
H3B4C9_LATCH	KIDINS220	ENSLACP00000016750	ENSLACP00000005285	PDZ domain-containing protein.	Kinase D interacting substrate 220.	0.465
H3B4C9_LATCH	MAGI2	ENSLACP00000016750	ENSLACP00000014418	PDZ domain-containing protein.	Uncharacterized protein.	0.900
H3B4C9_LATCH	NKPD1	ENSLACP00000016750	ENSLACP00000006771	PDZ domain-containing protein.	NTPase, KAP family P-loop domain containing 1.	0.465
KIDINS220	H3B4C9_LATCH	ENSLACP00000005285	ENSLACP00000016750	Kinase D interacting substrate 220.	PDZ domain-containing protein.	0.465
KIDINS220	MAGI2	ENSLACP00000005285	ENSLACP00000014418	Kinase D interacting substrate 220.	Uncharacterized protein.	0.552
KIDINS220	NTRK1	ENSLACP00000005285	ENSLACP00000017880	Kinase D interacting substrate 220.	Tyrosine-protein kinase receptor.	0.421
LOC102345670	BDNF	ENSLACP00000022200	ENSLACP00000012950	Sortilin.	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	0.735
LOC102345670	NTF3	ENSLACP00000022200	ENSLACP00000007800	Sortilin.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.608
LOC102345670	NTF4	ENSLACP00000022200	ENSLACP00000005834	Sortilin.	Neurotrophin 4; Belongs to the NGF-beta family.	0.526
MAGI2	H3AI06_LATCH	ENSLACP00000014418	ENSLACP00000009277	Uncharacterized protein.	KAP NTPase domain-containing protein.	0.552
MAGI2	H3B4C9_LATCH	ENSLACP00000014418	ENSLACP00000016750	Uncharacterized protein.	PDZ domain-containing protein.	0.900