(41 nodes) Regulation of multicellular organism growth network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MFSD2A	Major facilitator superfamily domain containing 2A. (549 aa)
	GHSR	Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (367 aa)
	BBS2	Bardet-Biedl syndrome 2 protein homolog. (724 aa)
	PPIB	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (224 aa)
	FXN	Frataxin. (194 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	CREB1	cAMP responsive element binding protein 1. (347 aa)
	H3B924_LATCH	TGF_BETA_2 domain-containing protein. (356 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (689 aa)
	DRD2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (450 aa)
	LGMN	Legumain. (436 aa)
	LOC102356247	Uncharacterized protein. (636 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (854 aa)
	PEX5	Peroxisomal biogenesis factor 5. (666 aa)
	APP	Amyloid beta precursor protein. (652 aa)
	BBS4	Bardet-Biedl syndrome 4. (537 aa)
	SLC6A3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (624 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
	ADRB3	Adrenoceptor beta 3a. (407 aa)
	LOC102348150	Signal transducer and activator of transcription. (786 aa)
	TNKS2	Poly [ADP-ribose] polymerase. (1174 aa)
	ADRB2	Adrenoceptor beta 2. (432 aa)
	PTCH1	Patched 1. (1287 aa)
	MBD5	Methyl-CpG binding domain protein 5. (1740 aa)
	GPAT4	Glycerol-3-phosphate acyltransferase 4. (455 aa)
	IGF2	Insulin like growth factor 2. (207 aa)
	NIPBL	Nipped-B protein. (2707 aa)
	SOCS2	Suppressor of cytokine signaling 2. (176 aa)
	EZR	Ezrin. (591 aa)
	MKKS	McKusick-Kaufman syndrome. (575 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (453 aa)
	FTO	FTO alpha-ketoglutarate dependent dioxygenase. (423 aa)
	H3AHR9_LATCH	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (336 aa)
	ADRB1	Adrenoceptor beta 1. (394 aa)
	GAMT	Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. (236 aa)
	PLS1	Plastin 1. (621 aa)
	HTRA2	HtrA serine peptidase 2. (525 aa)
	LOC102351332	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1067 aa)
	STAT3	Signal transducer and activator of transcription. (763 aa)
	SGPL1	Sphingosine-1-phosphate lyase 1. (566 aa)
	RAI1	Retinoic acid induced 1. (1783 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRB1	ADRB3	ENSLACP00000011780	ENSLACP00000002909	Adrenoceptor beta 1.	Adrenoceptor beta 3a.	0.668
ADRB2	ADRB3	ENSLACP00000003966	ENSLACP00000002909	Adrenoceptor beta 2.	Adrenoceptor beta 3a.	0.680
ADRB3	ADRB1	ENSLACP00000002909	ENSLACP00000011780	Adrenoceptor beta 3a.	Adrenoceptor beta 1.	0.668
ADRB3	ADRB2	ENSLACP00000002909	ENSLACP00000003966	Adrenoceptor beta 3a.	Adrenoceptor beta 2.	0.680
ADRB3	DRD2	ENSLACP00000002909	ENSLACP00000020922	Adrenoceptor beta 3a.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.424
APP	CREB1	ENSLACP00000001643	ENSLACP00000018100	Amyloid beta precursor protein.	cAMP responsive element binding protein 1.	0.418
APP	GHSR	ENSLACP00000001643	ENSLACP00000015758	Amyloid beta precursor protein.	Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family.	0.465
APP	H3AHR9_LATCH	ENSLACP00000001643	ENSLACP00000009190	Amyloid beta precursor protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.420
BBS2	BBS4	ENSLACP00000017026	ENSLACP00000002102	Bardet-Biedl syndrome 2 protein homolog.	Bardet-Biedl syndrome 4.	0.998
BBS2	MKKS	ENSLACP00000017026	ENSLACP00000006659	Bardet-Biedl syndrome 2 protein homolog.	McKusick-Kaufman syndrome.	0.427
BBS2	SMO	ENSLACP00000017026	ENSLACP00000002758	Bardet-Biedl syndrome 2 protein homolog.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.705
BBS4	BBS2	ENSLACP00000002102	ENSLACP00000017026	Bardet-Biedl syndrome 4.	Bardet-Biedl syndrome 2 protein homolog.	0.998
BBS4	SMO	ENSLACP00000002102	ENSLACP00000002758	Bardet-Biedl syndrome 4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.692
CREB1	APP	ENSLACP00000018100	ENSLACP00000001643	cAMP responsive element binding protein 1.	Amyloid beta precursor protein.	0.418
CREB1	FTO	ENSLACP00000018100	ENSLACP00000008840	cAMP responsive element binding protein 1.	FTO alpha-ketoglutarate dependent dioxygenase.	0.686
CREB1	STAT3	ENSLACP00000018100	ENSLACP00000013656	cAMP responsive element binding protein 1.	Signal transducer and activator of transcription.	0.575
DRD2	ADRB3	ENSLACP00000020922	ENSLACP00000002909	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Adrenoceptor beta 3a.	0.424
DRD2	SLC6A3	ENSLACP00000020922	ENSLACP00000002580	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.727
EZR	PLS1	ENSLACP00000006611	ENSLACP00000012583	Ezrin.	Plastin 1.	0.691
FTO	CREB1	ENSLACP00000008840	ENSLACP00000018100	FTO alpha-ketoglutarate dependent dioxygenase.	cAMP responsive element binding protein 1.	0.686