(35 nodes) Positive regulation of T cell proliferation network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
	CARD11	Caspase recruitment domain family member 11. (1137 aa)
	NCK1	Cytoplasmic protein. (377 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (559 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (830 aa)
	LOC102346338	ZP domain-containing protein. (328 aa)
	VTCN1	V-set domain containing T cell activation inhibitor 1. (279 aa)
	LOC102348796	Uncharacterized protein. (497 aa)
	M3XIR6_LATCH	Uncharacterized protein. (269 aa)
	IL18	Uncharacterized protein. (200 aa)
	CD40LG	CD40 ligand; Belongs to the tumor necrosis factor family. (284 aa)
	CD276	CD276 molecule. (324 aa)
	VTCN1-2	Uncharacterized protein. (232 aa)
	SASH3	SAM and SH3 domain containing 3. (433 aa)
	LOC102363504	Tyrosine-protein kinase. (1116 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	DHPS	Deoxyhypusine synthase. (365 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	IL6ST	Interleukin 6 signal transducer. (922 aa)
	LOC102346566	Annexin. (343 aa)
	LOC102349920	Uncharacterized protein. (199 aa)
	FADD	Fas associated via death domain. (193 aa)
	IL6	Uncharacterized protein. (149 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (854 aa)
	SLC7A1	Solute carrier family 7 member 1. (658 aa)
	ZAP70	Tyrosine-protein kinase. (609 aa)
	IL12RB2	Interleukin 12 receptor subunit beta 2. (836 aa)
	PDCD1LG2	Programmed cell death 1 ligand 2. (247 aa)
	JAK2	Tyrosine-protein kinase. (1152 aa)
	RPS3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (254 aa)
	TNFSF13B	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (122 aa)
	H3A8Y5_LATCH	Uncharacterized protein. (477 aa)
	IGF2	Insulin like growth factor 2. (207 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (567 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CARD11	FADD	ENSLACP00000004229	ENSLACP00000009943	Caspase recruitment domain family member 11.	Fas associated via death domain.	0.463
CARD11	LOC102348796	ENSLACP00000004229	ENSLACP00000023619	Caspase recruitment domain family member 11.	Uncharacterized protein.	0.521
CARD11	RIPK2	ENSLACP00000004229	ENSLACP00000004499	Caspase recruitment domain family member 11.	Receptor interacting serine/threonine kinase 2.	0.521
CARD11	SYK	ENSLACP00000004229	ENSLACP00000012982	Caspase recruitment domain family member 11.	Tyrosine-protein kinase.	0.692
CARD11	TRAF6	ENSLACP00000004229	ENSLACP00000003556	Caspase recruitment domain family member 11.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.833
CARD11	ZAP70	ENSLACP00000004229	ENSLACP00000008633	Caspase recruitment domain family member 11.	Tyrosine-protein kinase.	0.600
CD276	CD40LG	ENSLACP00000017684	ENSLACP00000017831	CD276 molecule.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.597
CD40LG	CD276	ENSLACP00000017831	ENSLACP00000017684	CD40 ligand; Belongs to the tumor necrosis factor family.	CD276 molecule.	0.597
CD40LG	IL18	ENSLACP00000017831	ENSLACP00000021930	CD40 ligand; Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.430
CD40LG	IL6	ENSLACP00000017831	ENSLACP00000009318	CD40 ligand; Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.552
CD40LG	TNFSF13B	ENSLACP00000017831	ENSLACP00000006159	CD40 ligand; Belongs to the tumor necrosis factor family.	TNF superfamily member 13b; Belongs to the tumor necrosis factor family.	0.832
CD40LG	TRAF6	ENSLACP00000017831	ENSLACP00000003556	CD40 ligand; Belongs to the tumor necrosis factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.431
FADD	CARD11	ENSLACP00000009943	ENSLACP00000004229	Fas associated via death domain.	Caspase recruitment domain family member 11.	0.463
FADD	LOC102348796	ENSLACP00000009943	ENSLACP00000023619	Fas associated via death domain.	Uncharacterized protein.	0.648
FADD	RIPK2	ENSLACP00000009943	ENSLACP00000004499	Fas associated via death domain.	Receptor interacting serine/threonine kinase 2.	0.702
FADD	SYK	ENSLACP00000009943	ENSLACP00000012982	Fas associated via death domain.	Tyrosine-protein kinase.	0.661
FADD	TRAF6	ENSLACP00000009943	ENSLACP00000003556	Fas associated via death domain.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.727
FADD	ZAP70	ENSLACP00000009943	ENSLACP00000008633	Fas associated via death domain.	Tyrosine-protein kinase.	0.652
H3A8Y5_LATCH	ZAP70	ENSLACP00000006106	ENSLACP00000008633	Uncharacterized protein.	Tyrosine-protein kinase.	0.416
IGF2	LEP	ENSLACP00000004956	ENSLACP00000011398	Insulin like growth factor 2.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family.	0.451