(80 nodes) Regulation of T cell proliferation network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD81	Tetraspanin. (184 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (830 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (559 aa)
	NCK1	Cytoplasmic protein. (377 aa)
	CARD11	Caspase recruitment domain family member 11. (1137 aa)
	SLC7A1	Solute carrier family 7 member 1. (658 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (854 aa)
	IL6	Uncharacterized protein. (149 aa)
	TWSG1	Twisted gastrulation BMP signaling modulator 1. (220 aa)
	FADD	Fas associated via death domain. (193 aa)
	LOC102349920	Uncharacterized protein. (199 aa)
	CTLA4	IG domain-containing protein. (186 aa)
	LOC102346566	Annexin. (343 aa)
	IL6ST	Interleukin 6 signal transducer. (922 aa)
	TNFRSF9	TNF receptor superfamily member 9. (213 aa)
	NCK2	Cytoplasmic protein. (380 aa)
	H3ALU1_LATCH	Uncharacterized protein. (1358 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	SH3RF1	SH3 domain containing ring finger 1. (745 aa)
	LOC102358329	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (161 aa)
	H3ASA2_LATCH	Ig-like domain-containing protein. (290 aa)
	DHPS	Deoxyhypusine synthase. (365 aa)
	H3AT06_LATCH	Uncharacterized protein. (88 aa)
	NDFIP1	Nedd4 family interacting protein 1. (212 aa)
	SYK	Tyrosine-protein kinase. (616 aa)
	TMEM131L	Transmembrane 131 like. (1522 aa)
	H3AWB3_LATCH	Uncharacterized protein. (560 aa)
	PAWR	Uncharacterized protein. (118 aa)
	CD276	CD276 molecule. (324 aa)
	VTCN1-2	Uncharacterized protein. (232 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	GLMN	Glomulin, FKBP associated protein. (597 aa)
	SASH3	SAM and SH3 domain containing 3. (433 aa)
	H3B0Y6_LATCH	PRKC, apoptosis, WT1, regulator. (191 aa)
	LOC102363504	Tyrosine-protein kinase. (1116 aa)
	GPNMB	Glycoprotein nmb. (607 aa)
	LOC102348796	Uncharacterized protein. (497 aa)
	TNFRSF1B	TNF receptor superfamily member 1B. (465 aa)
	HHLA2	Ig-like domain-containing protein. (145 aa)
	M3XIR6_LATCH	Uncharacterized protein. (269 aa)
	M3XIM8_LATCH	Ig-like domain-containing protein. (241 aa)
	MAD1L1	Mitotic arrest deficient 1 like 1. (684 aa)
	IL18	Uncharacterized protein. (200 aa)
	M3XGJ3_LATCH	TNFR-Cys domain-containing protein. (163 aa)
	ITCH	E3 ubiquitin-protein ligase. (880 aa)
	LGALS3	Galectin. (274 aa)
	LOC102351798	Galectin. (167 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	LOC102353843	Uncharacterized protein. (335 aa)
	ARG2	Arginase. (363 aa)
	LGALS9	Galectin. (369 aa)
	H3BAW7_LATCH	Uncharacterized protein. (190 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1123 aa)
	PELI1	Pellino E3 ubiquitin protein ligase 1. (445 aa)
	TNFRSF21	TNF receptor superfamily member 21. (651 aa)
	CD40LG	CD40 ligand; Belongs to the tumor necrosis factor family. (284 aa)
	H3A3Z5_LATCH	Uncharacterized protein. (679 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1331 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (585 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (567 aa)
	IGF2	Insulin like growth factor 2. (207 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1241 aa)
	DLG5	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1821 aa)
	H3A8Y5_LATCH	Uncharacterized protein. (477 aa)
	TNFSF13B	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (122 aa)
	RPS3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (254 aa)
	JAK2	Tyrosine-protein kinase. (1152 aa)
	PDCD1LG2	Programmed cell death 1 ligand 2. (247 aa)
	TSPAN32	Uncharacterized protein. (146 aa)
	IL12RB2	Interleukin 12 receptor subunit beta 2. (836 aa)
	MARCHF7	Membrane associated ring-CH-type finger 7. (733 aa)
	LRRC1	Uncharacterized protein. (155 aa)
	ZAP70	Tyrosine-protein kinase. (609 aa)
	VTCN1	V-set domain containing T cell activation inhibitor 1. (279 aa)
	H2ZV40_LATCH	Protein kinase domain-containing protein. (266 aa)
	IRF1	Interferon regulatory factor. (264 aa)
	H2ZX10_LATCH	Uncharacterized protein. (436 aa)
	LOC102346338	ZP domain-containing protein. (328 aa)
	CEBPB	CCAAT/enhancer-binding protein. (291 aa)
	PTPN6	Protein tyrosine phosphatase non-receptor type 6. (338 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARG2	DHPS	ENSLACP00000020265	ENSLACP00000012669	Arginase.	Deoxyhypusine synthase.	0.646
ARG2	IL6	ENSLACP00000020265	ENSLACP00000009318	Arginase.	Uncharacterized protein.	0.446
CARD11	FADD	ENSLACP00000004229	ENSLACP00000009943	Caspase recruitment domain family member 11.	Fas associated via death domain.	0.463
CARD11	LOC102348796	ENSLACP00000004229	ENSLACP00000023619	Caspase recruitment domain family member 11.	Uncharacterized protein.	0.521
CARD11	RIPK2	ENSLACP00000004229	ENSLACP00000004499	Caspase recruitment domain family member 11.	Receptor interacting serine/threonine kinase 2.	0.521
CARD11	SYK	ENSLACP00000004229	ENSLACP00000012982	Caspase recruitment domain family member 11.	Tyrosine-protein kinase.	0.692
CARD11	TRAF6	ENSLACP00000004229	ENSLACP00000003556	Caspase recruitment domain family member 11.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.833
CARD11	ZAP70	ENSLACP00000004229	ENSLACP00000008633	Caspase recruitment domain family member 11.	Tyrosine-protein kinase.	0.600
CD276	CD40LG	ENSLACP00000017684	ENSLACP00000017831	CD276 molecule.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.597
CD276	CTLA4	ENSLACP00000017684	ENSLACP00000010132	CD276 molecule.	IG domain-containing protein.	0.689
CD276	TNFRSF9	ENSLACP00000017684	ENSLACP00000010264	CD276 molecule.	TNF receptor superfamily member 9.	0.579
CD40LG	CD276	ENSLACP00000017831	ENSLACP00000017684	CD40 ligand; Belongs to the tumor necrosis factor family.	CD276 molecule.	0.597
CD40LG	CTLA4	ENSLACP00000017831	ENSLACP00000010132	CD40 ligand; Belongs to the tumor necrosis factor family.	IG domain-containing protein.	0.642
CD40LG	IL18	ENSLACP00000017831	ENSLACP00000021930	CD40 ligand; Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.430
CD40LG	IL6	ENSLACP00000017831	ENSLACP00000009318	CD40 ligand; Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.552
CD40LG	LOC102358329	ENSLACP00000017831	ENSLACP00000012214	CD40 ligand; Belongs to the tumor necrosis factor family.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.720
CD40LG	M3XGJ3_LATCH	ENSLACP00000017831	ENSLACP00000021849	CD40 ligand; Belongs to the tumor necrosis factor family.	TNFR-Cys domain-containing protein.	0.966
CD40LG	M3XIM8_LATCH	ENSLACP00000017831	ENSLACP00000022584	CD40 ligand; Belongs to the tumor necrosis factor family.	Ig-like domain-containing protein.	0.449
CD40LG	TNFRSF1B	ENSLACP00000017831	ENSLACP00000023381	CD40 ligand; Belongs to the tumor necrosis factor family.	TNF receptor superfamily member 1B.	0.635
CD40LG	TNFRSF9	ENSLACP00000017831	ENSLACP00000010264	CD40 ligand; Belongs to the tumor necrosis factor family.	TNF receptor superfamily member 9.	0.562