(27 nodes) Regulation of protein import into nucleus network (Latimeria chalumnae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BAG3	BCL2 associated athanogene 3. (561 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (820 aa)
	GLI3	GLI family zinc finger 3. (1456 aa)
	RAB23	RAB23, member RAS oncogene family. (237 aa)
	EPM2A	EPM2A glucan phosphatase, laforin. (228 aa)
	JUP	Junction plakoglobin. (694 aa)
	H3AA19_LATCH	Uncharacterized protein. (62 aa)
	CHP1	Calcineurin like EF-hand protein 1. (195 aa)
	SIRT6	Sirtuin 6. (375 aa)
	DMAP1	DNA methyltransferase 1 associated protein 1. (402 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. Belongs to the leptin family. (169 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (465 aa)
	UBR5	Ubiquitin protein ligase E3 component n-recognin 5. (2787 aa)
	ECT2	Epithelial cell transforming 2. (919 aa)
	ZPR1	ZPR1 zinc finger. (470 aa)
	EFCAB7	EF-hand calcium binding domain 7. (631 aa)
	NOLC1	Nucleolar and coiled-body phosphoprotein 1. (954 aa)
	IPO5	Importin 5. (1107 aa)
	TPR	Translocated promoter region, nuclear basket protein. (2360 aa)
	NUP58	Nucleoporin 58. (604 aa)
	NF1	Neurofibromin 1. (2814 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (600 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (401 aa)
	CHP2	Calcineurin like EF-hand protein 2. (194 aa)
	APOD	Apolipoprotein D; Belongs to the calycin superfamily. Lipocalin family. (189 aa)
	NUP54	Nucleoporin 54. (504 aa)
	H2ZSK8_LATCH	TYR_PHOSPHATASE_2 domain-containing protein. (101 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EFCAB7	GLI3	ENSLACP00000016940	ENSLACP00000004224	EF-hand calcium binding domain 7.	GLI family zinc finger 3.	0.432
EPM2A	H2ZSK8_LATCH	ENSLACP00000004885	ENSLACP00000000379	EPM2A glucan phosphatase, laforin.	TYR_PHOSPHATASE_2 domain-containing protein.	0.921
GLI3	EFCAB7	ENSLACP00000004224	ENSLACP00000016940	GLI family zinc finger 3.	EF-hand calcium binding domain 7.	0.432
GLI3	RAB23	ENSLACP00000004224	ENSLACP00000004523	GLI family zinc finger 3.	RAB23, member RAS oncogene family.	0.554
GLI3	SMO	ENSLACP00000004224	ENSLACP00000002758	GLI family zinc finger 3.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.894
H2ZSK8_LATCH	EPM2A	ENSLACP00000000379	ENSLACP00000004885	TYR_PHOSPHATASE_2 domain-containing protein.	EPM2A glucan phosphatase, laforin.	0.921
H3AA19_LATCH	IPO5	ENSLACP00000006490	ENSLACP00000017413	Uncharacterized protein.	Importin 5.	0.649
H3AA19_LATCH	NUP58	ENSLACP00000006490	ENSLACP00000018156	Uncharacterized protein.	Nucleoporin 58.	0.973
H3AA19_LATCH	TPR	ENSLACP00000006490	ENSLACP00000017531	Uncharacterized protein.	Translocated promoter region, nuclear basket protein.	0.804
IPO5	H3AA19_LATCH	ENSLACP00000017413	ENSLACP00000006490	Importin 5.	Uncharacterized protein.	0.649
IPO5	NUP54	ENSLACP00000017413	ENSLACP00000022798	Importin 5.	Nucleoporin 54.	0.649
IPO5	NUP58	ENSLACP00000017413	ENSLACP00000018156	Importin 5.	Nucleoporin 58.	0.516
JUP	PSEN1	ENSLACP00000006244	ENSLACP00000012775	Junction plakoglobin.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.550
NUP54	IPO5	ENSLACP00000022798	ENSLACP00000017413	Nucleoporin 54.	Importin 5.	0.649
NUP54	NUP58	ENSLACP00000022798	ENSLACP00000018156	Nucleoporin 54.	Nucleoporin 58.	0.973
NUP54	TPR	ENSLACP00000022798	ENSLACP00000017531	Nucleoporin 54.	Translocated promoter region, nuclear basket protein.	0.804
NUP58	H3AA19_LATCH	ENSLACP00000018156	ENSLACP00000006490	Nucleoporin 58.	Uncharacterized protein.	0.973
NUP58	IPO5	ENSLACP00000018156	ENSLACP00000017413	Nucleoporin 58.	Importin 5.	0.516
NUP58	NUP54	ENSLACP00000018156	ENSLACP00000022798	Nucleoporin 58.	Nucleoporin 54.	0.973
NUP58	TPR	ENSLACP00000018156	ENSLACP00000017531	Nucleoporin 58.	Translocated promoter region, nuclear basket protein.	0.775