(69 nodes) Ear morphogenesis network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SLITRK6	SLIT and NTRK like family member 6. (841 aa)
	GAS1	Growth arrest specific 1. (259 aa)
	WDR19	WD repeat domain 19. (895 aa)
	PDZD7	PDZ domain containing 7. (505 aa)
	DLX5	Distal-less homeobox 5. (290 aa)
	H2ZYB6_LATCH	Uncharacterized protein. (324 aa)
	DLX6	Distal-less homeobox 6. (266 aa)
	MYO3A	Myosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (600 aa)
	GATA3	GATA binding protein 3. (447 aa)
	OTOP1	Otopetrin 1. (584 aa)
	NKX3-2	NK3 homeobox 2. (282 aa)
	H3A478_LATCH	PDZ domain-containing protein. (297 aa)
	MSX1	Msh homeobox 1. (256 aa)
	NIPBL	Nipped-B protein. (2707 aa)
	GSC	Goosecoid homeobox. (243 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (424 aa)
	OSR2	Odd-skipped related transciption factor 2. (314 aa)
	GBX2	Gastrulation brain homeobox 2. (344 aa)
	MYO3B	Myosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (805 aa)
	NAGLU	N-acetyl-alpha-glucosaminidase. (614 aa)
	OSR1	Odd-skipped related transcription factor 1. (259 aa)
	LOC102360373	Fork-head domain-containing protein. (374 aa)
	TBX3	T-box transcription factor 3. (713 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (1197 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LRIG1	Leucine rich repeats and immunoglobulin like domains 1. (1097 aa)
	H3AHJ4_LATCH	Ion_trans domain-containing protein; Belongs to the potassium channel family. (298 aa)
	MYO6	Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1230 aa)
	H3AIG1_LATCH	Uncharacterized protein. (317 aa)
	PTPRQ	Protein tyrosine phosphatase receptor type Q. (1795 aa)
	CLDN7	Claudin 7b. (145 aa)
	KCNQ1	Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (351 aa)
	H3ALU1_LATCH	Uncharacterized protein. (1358 aa)
	LOC102357614	Fork-head domain-containing protein. (345 aa)
	NBL1	NBL1, DAN family BMP antagonist. (184 aa)
	USH1G	USH1 protein network component sans. (471 aa)
	GRXCR2	Glutaredoxin and cysteine rich domain containing 2. (260 aa)
	HESX1	HESX homeobox 1. (185 aa)
	PLS1	Plastin 1. (621 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (604 aa)
	TIFAB	TIFA inhibitor. (149 aa)
	BLOC1S5	Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). (154 aa)
	SOBP	Sine oculis binding protein homolog. (634 aa)
	FOXG1	Forkhead box G1. (409 aa)
	TMIE	Transmembrane inner ear. (130 aa)
	LOC102362405	Homeobox domain-containing protein. (954 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1076 aa)
	TPRN	Taperin. (771 aa)
	HPN	Hepsin; Belongs to the peptidase S1 family. (415 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1067 aa)
	SIX2	SIX homeobox 2. (289 aa)
	CTHRC1	Collagen triple helix repeat containing 1. (151 aa)
	TBX2	T-box transcription factor 2. (689 aa)
	TTC39C	Tetratricopeptide repeat domain 39C. (448 aa)
	LOC102365660	Uncharacterized protein. (187 aa)
	LOC102366172	Uncharacterized protein. (183 aa)
	USH1C	USH1 protein network component harmonin. (830 aa)
	LRIG3	Leucine rich repeats and immunoglobulin like domains 3. (1035 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (689 aa)
	EDN1	Endothelin 1. (216 aa)
	H3BBK0_LATCH	Uncharacterized protein. (783 aa)
	OTX1	Orthodenticle homeobox 1. (339 aa)
	ALDH1A3	Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (507 aa)
	SIX4	SIX homeobox 4. (742 aa)
	SIX1	SIX homeobox 1. (283 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (373 aa)
	SLC44A4	Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (470 aa)
	WDPCP	WD repeat containing planar cell polarity effector. (727 aa)
	LRRC1	Uncharacterized protein. (155 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLX5	DLX6	ENSLACP00000001948	ENSLACP00000002479	Distal-less homeobox 5.	Distal-less homeobox 6.	0.838
DLX5	EDN1	ENSLACP00000001948	ENSLACP00000018825	Distal-less homeobox 5.	Endothelin 1.	0.592
DLX5	EDNRA	ENSLACP00000001948	ENSLACP00000006100	Distal-less homeobox 5.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.590
DLX5	FGF8	ENSLACP00000001948	ENSLACP00000007843	Distal-less homeobox 5.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.534
DLX5	FOXG1	ENSLACP00000001948	ENSLACP00000014746	Distal-less homeobox 5.	Forkhead box G1.	0.506
DLX5	SIX1	ENSLACP00000001948	ENSLACP00000021104	Distal-less homeobox 5.	SIX homeobox 1.	0.446
DLX5	WNT1	ENSLACP00000001948	ENSLACP00000021628	Distal-less homeobox 5.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.450
DLX6	DLX5	ENSLACP00000002479	ENSLACP00000001948	Distal-less homeobox 6.	Distal-less homeobox 5.	0.838
DLX6	EDN1	ENSLACP00000002479	ENSLACP00000018825	Distal-less homeobox 6.	Endothelin 1.	0.467
DLX6	EDNRA	ENSLACP00000002479	ENSLACP00000006100	Distal-less homeobox 6.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.490
DLX6	FGF8	ENSLACP00000002479	ENSLACP00000007843	Distal-less homeobox 6.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.423
EDN1	DLX5	ENSLACP00000018825	ENSLACP00000001948	Endothelin 1.	Distal-less homeobox 5.	0.592
EDN1	DLX6	ENSLACP00000018825	ENSLACP00000002479	Endothelin 1.	Distal-less homeobox 6.	0.467
EDN1	EDNRA	ENSLACP00000018825	ENSLACP00000006100	Endothelin 1.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.999
EDN1	FGF8	ENSLACP00000018825	ENSLACP00000007843	Endothelin 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.633
EDN1	NKX3-2	ENSLACP00000018825	ENSLACP00000004053	Endothelin 1.	NK3 homeobox 2.	0.426
EDNRA	DLX5	ENSLACP00000006100	ENSLACP00000001948	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Distal-less homeobox 5.	0.590
EDNRA	DLX6	ENSLACP00000006100	ENSLACP00000002479	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Distal-less homeobox 6.	0.490
EDNRA	EDN1	ENSLACP00000006100	ENSLACP00000018825	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.999
FGF8	DLX5	ENSLACP00000007843	ENSLACP00000001948	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Distal-less homeobox 5.	0.534