(48 nodes) Response to hydrogen peroxide network (Latimeria chalumnae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (907 aa)
	LOC102350310	GBP domain-containing protein. (339 aa)
	PPP1R15B	Protein phosphatase 1 regulatory subunit 15B. (703 aa)
	IMPACT	Impact RWD domain protein. (319 aa)
	CRYAB	Crystallin alpha B; Belongs to the small heat shock protein (HSP20) family. (173 aa)
	SETX	Senataxin. (2165 aa)
	AXL	AXL receptor tyrosine kinase. (872 aa)
	LOC102349421	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (528 aa)
	EDN1	Endothelin 1. (216 aa)
	LOC102362765	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (537 aa)
	BAK1	BCL2 antagonist/killer 1. (239 aa)
	FXN	Frataxin. (194 aa)
	PRDX3	Peroxiredoxin 3. (254 aa)
	TNFAIP3	TNF alpha induced protein 3. (785 aa)
	FOSL1	FOS like 1, AP-1 transcription factor subunit. (268 aa)
	TRPM2	Transient receptor potential cation channel subfamily M member 2. (1473 aa)
	TRPA1	Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1138 aa)
	ECT2	Epithelial cell transforming 2. (919 aa)
	ANKZF1	Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1. (731 aa)
	PDCD10	Programmed cell death 10. (210 aa)
	STK24	Serine/threonine kinase 24. (432 aa)
	LOC102359041	Zgc:153993. (208 aa)
	STK25	Serine/threonine kinase 25. (336 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (667 aa)
	LOC102346566	Annexin. (343 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (590 aa)
	PARK7	Parkinsonism associated deglycase. (217 aa)
	IL6	Uncharacterized protein. (149 aa)
	NET1	Neuroepithelial cell transforming 1. (631 aa)
	ZNF277	Zinc finger protein 277. (443 aa)
	SIRT1	Sirtuin 1. (729 aa)
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (521 aa)
	AREG	Amphiregulin. (235 aa)
	H3AEK5_LATCH	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (268 aa)
	KDM6B	Lysine demethylase 6B. (1638 aa)
	RPS3	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (254 aa)
	SIGMAR1	Sigma non-opioid intracellular receptor 1. (223 aa)
	H3A2T1_LATCH	Uncharacterized protein. (573 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (552 aa)
	H2ZZI1_LATCH	RING-type domain-containing protein. (424 aa)
	OSER1	Oxidative stress responsive serine rich 1. (298 aa)
	STK26	Serine/threonine kinase 26. (415 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (657 aa)
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (625 aa)
	H2ZV40_LATCH	Protein kinase domain-containing protein. (266 aa)
	FABP1	Fatty acid binding protein 1. (98 aa)
	MAPK13	Mitogen-activated protein kinase. (162 aa)
	GLRX2	Glutaredoxin 2. (149 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIFM1	LOC102359041	ENSLACP00000001333	ENSLACP00000012675	Apoptosis inducing factor mitochondria associated 1.	Zgc:153993.	0.926
BAK1	LOC102359041	ENSLACP00000018296	ENSLACP00000012675	BCL2 antagonist/killer 1.	Zgc:153993.	0.900
CAT	GLRX2	ENSLACP00000008889	ENSLACP00000000117	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Glutaredoxin 2.	0.446
CAT	PARK7	ENSLACP00000008889	ENSLACP00000009483	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Parkinsonism associated deglycase.	0.774
CAT	PRDX3	ENSLACP00000008889	ENSLACP00000016627	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Peroxiredoxin 3.	0.727
EDN1	IL6	ENSLACP00000018825	ENSLACP00000009318	Endothelin 1.	Uncharacterized protein.	0.531
FABP1	LOC102362765	ENSLACP00000000844	ENSLACP00000018641	Fatty acid binding protein 1.	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family.	0.427
FOSL1	MAPK13	ENSLACP00000015752	ENSLACP00000000782	FOS like 1, AP-1 transcription factor subunit.	Mitogen-activated protein kinase.	0.713
FXN	SETX	ENSLACP00000017270	ENSLACP00000020632	Frataxin.	Senataxin.	0.535
GLRX2	CAT	ENSLACP00000000117	ENSLACP00000008889	Glutaredoxin 2.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	0.446
H2ZV40_LATCH	RIPK1	ENSLACP00000001261	ENSLACP00000011259	Protein kinase domain-containing protein.	Receptor interacting serine/threonine kinase 1.	0.999
H2ZV40_LATCH	TNFAIP3	ENSLACP00000001261	ENSLACP00000016527	Protein kinase domain-containing protein.	TNF alpha induced protein 3.	0.544
IL6	EDN1	ENSLACP00000009318	ENSLACP00000018825	Uncharacterized protein.	Endothelin 1.	0.531
IL6	NFE2L2	ENSLACP00000009318	ENSLACP00000009979	Uncharacterized protein.	Nuclear factor, erythroid 2 like 2.	0.585
IL6	SIRT1	ENSLACP00000009318	ENSLACP00000009079	Uncharacterized protein.	Sirtuin 1.	0.560
IL6	TNFAIP3	ENSLACP00000009318	ENSLACP00000016527	Uncharacterized protein.	TNF alpha induced protein 3.	0.499
KDM6B	RPS3	ENSLACP00000007999	ENSLACP00000006908	Lysine demethylase 6B.	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family.	0.724
KDM6B	SIRT1	ENSLACP00000007999	ENSLACP00000009079	Lysine demethylase 6B.	Sirtuin 1.	0.441
LOC102359041	AIFM1	ENSLACP00000012675	ENSLACP00000001333	Zgc:153993.	Apoptosis inducing factor mitochondria associated 1.	0.926
LOC102359041	BAK1	ENSLACP00000012675	ENSLACP00000018296	Zgc:153993.	BCL2 antagonist/killer 1.	0.900