(128 nodes) Regulation of I-kappaB kinase/NF-kappaB signaling network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102355629	Uncharacterized protein. (512 aa)
	ABL2	Tyrosine-protein kinase. (1175 aa)
	TRIM62	B30.2/SPRY domain-containing protein. (312 aa)
	S100B	S100 calcium binding protein B; Belongs to the S-100 family. (114 aa)
	H3A8H2_LATCH	Uncharacterized protein. (541 aa)
	LOC102365549	NEMO domain-containing protein. (417 aa)
	RBCK1	IBR domain-containing protein. (175 aa)
	LOC102348796	Uncharacterized protein. (497 aa)
	TANK	Uncharacterized protein. (72 aa)
	OTUD7B	OTU deubiquitinase 7B. (872 aa)
	UBD	Uncharacterized protein. (163 aa)
	MUL1	Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
	PPM1A	Protein phosphatase, Mg2+/Mn2+ dependent 1A. (383 aa)
	NFKBIB	NFKB inhibitor beta. (397 aa)
	OTUD7A	OTU deubiquitinase 7A. (884 aa)
	TIRAP	TIR domain containing adaptor protein. (267 aa)
	UBE2V1	UBIQUITIN_CONJUGAT_2 domain-containing protein. (153 aa)
	CARD9	Caspase recruitment domain family member 9. (567 aa)
	NLRX1	NLR family member X1. (855 aa)
	PINK1	PTEN induced kinase 1. (467 aa)
	ALPK1	Alpha kinase 1. (1236 aa)
	CCDC22	Coiled-coil domain containing 22. (647 aa)
	H3A526_LATCH	Uncharacterized protein; Belongs to the peptidase C14A family. (486 aa)
	EDAR	Ectodysplasin A receptor. (454 aa)
	H3A4P0_LATCH	Ig-like domain-containing protein. (174 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (567 aa)
	LOC102358239	TRAF3 interacting protein 2-like. (392 aa)
	CARD11	Caspase recruitment domain family member 11. (1137 aa)
	CD40	TNFR-Cys domain-containing protein. (167 aa)
	H3A2R2_LATCH	Uncharacterized protein; Belongs to the peptidase C14A family. (480 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (559 aa)
	NR1H4	Nuclear receptor subfamily 1 group H member 4. (456 aa)
	H3BD11_LATCH	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (331 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (600 aa)
	RIOK3	Serine/threonine-protein kinase RIO3; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (513 aa)
	TNIP1	TNFAIP3 interacting protein 1. (532 aa)
	TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (691 aa)
	LOC102346019	C1q domain-containing protein. (226 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (286 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (672 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (454 aa)
	DHX36	DEAH-box helicase 36. (1001 aa)
	H2ZS89_LATCH	Uncharacterized protein. (189 aa)
	H2ZS97_LATCH	TNF_2 domain-containing protein. (143 aa)
	H2ZSA1_LATCH	CCHC NOA-type domain-containing protein. (158 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (259 aa)
	DDX21	DExD-box helicase 21. (582 aa)
	H2ZUJ2_LATCH	Uncharacterized protein. (466 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (474 aa)
	RNF31	Uncharacterized protein. (1087 aa)
	H2ZWA9_LATCH	Uncharacterized protein. (145 aa)
	LURAP1	Leucine rich adaptor protein 1. (282 aa)
	ZMYND11	Zinc finger MYND-type containing 11. (577 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (539 aa)
	TRIM32	Tripartite motif containing 32. (647 aa)
	CTH	Uncharacterized protein. (410 aa)
	LOC102350357	Uncharacterized protein. (577 aa)
	UNC5CL	Unc-5 family C-terminal like. (528 aa)
	CD74	CD74 molecule. (279 aa)
	PELI1	Pellino E3 ubiquitin protein ligase 1. (445 aa)
	TMEM101	Transmembrane protein 101. (247 aa)
	H3B7S8_LATCH	TNF receptor-associated factor. (449 aa)
	ABL1	Tyrosine-protein kinase. (1156 aa)
	TRADD	Death domain-containing protein. (313 aa)
	H3B6K7_LATCH	IKKbetaNEMObind domain-containing protein. (241 aa)
	FASLG	Fas ligand. (261 aa)
	LOC102359774	Uncharacterized protein. (218 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (556 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	ANKRD17	Ankyrin repeat domain 17. (2394 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (830 aa)
	AKAP13	PH domain-containing protein. (644 aa)
	CACTIN	Cactin, spliceosome C complex subunit. (768 aa)
	TNFAIP3	TNF alpha induced protein 3. (785 aa)
	H3B3L3_LATCH	NACHT domain-containing protein. (837 aa)
	TBK1	TANK binding kinase 1. (675 aa)
	TRAF1	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (565 aa)
	LPAR1	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (346 aa)
	TNIP3	TNFAIP3 interacting protein 3. (269 aa)
	H3AZ94_LATCH	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
	TERF2IP	TERF2 interacting protein. (455 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (673 aa)
	MAP3K3	Mitogen-activated protein kinase kinase kinase 3. (658 aa)
	PPM1B	PPM-type phosphatase domain-containing protein. (474 aa)
	SQSTM1	Sequestosome 1. (441 aa)
	TRAF3IP2	SEFIR domain-containing protein. (379 aa)
	H3AUD4_LATCH	PPM-type phosphatase domain-containing protein. (321 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (766 aa)
	RHOH	Ras homolog family member H. (189 aa)
	SHARPIN	Uncharacterized protein. (681 aa)
	JMJD8	Jumonji domain containing 8. (268 aa)
	EDA	Ectodysplasin A; Belongs to the tumor necrosis factor family. (223 aa)
	INAVA	Innate immunity activator. (599 aa)
	WDR83	WD repeat domain 83. (316 aa)
	AJUBA	Uncharacterized protein. (526 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (710 aa)
	DDX1	DEAD-box helicase 1. (740 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (854 aa)
	H3APL3_LATCH	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (534 aa)
	H3APB7_LATCH	Mitochondrial E3 ubiquitin protein ligase 1a. (243 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (667 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7. (580 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (614 aa)
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14. (940 aa)
	TRAF4	TNF receptor-associated factor. (434 aa)
	UFL1	UFM1 specific ligase 1. (792 aa)
	LOC102356355	TNFR-Cys domain-containing protein. (163 aa)
	TRIM14	Tripartite motif containing 14. (523 aa)
	LOC102359183	Chromosome 18 open reading frame 32. (86 aa)
	NLRC3	NLR family CARD domain containing 3. (1005 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
	LOC102349920	Uncharacterized protein. (199 aa)
	ROR1	Receptor tyrosine kinase like orphan receptor 1. (769 aa)
	FADD	Fas associated via death domain. (193 aa)
	H3AIP7_LATCH	Uncharacterized protein. (925 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (169 aa)
	SIRT1	Sirtuin 1. (729 aa)
	USP10	Ubiquitin carboxyl-terminal hydrolase. (752 aa)
	LURAP1L	Leucine rich adaptor protein 1 like. (127 aa)
	LTBR	Lymphotoxin beta receptor. (377 aa)
	TRIM8	Tripartite motif containing 8. (556 aa)
	HSPB1	Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (219 aa)
	H3AEV1_LATCH	TNF_2 domain-containing protein. (230 aa)
	DHX15	DEAH-box helicase 15. (765 aa)
	TIFA	TRAF interacting protein with forkhead associated domain. (203 aa)
	ZFAND6	Zinc finger AN1-type containing 6. (211 aa)
	H3AC95_LATCH	Uncharacterized protein. (483 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ABL2	ENSLACP00000017765	ENSLACP00000006377	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
ABL1	CTNNB1	ENSLACP00000017765	ENSLACP00000017209	Tyrosine-protein kinase.	Catenin beta 1.	0.684
ABL1	RHOH	ENSLACP00000017765	ENSLACP00000012746	Tyrosine-protein kinase.	Ras homolog family member H.	0.412
ABL2	ABL1	ENSLACP00000006377	ENSLACP00000017765	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.902
ABL2	CTNNB1	ENSLACP00000006377	ENSLACP00000017209	Tyrosine-protein kinase.	Catenin beta 1.	0.684
ABL2	RHOH	ENSLACP00000006377	ENSLACP00000012746	Tyrosine-protein kinase.	Ras homolog family member H.	0.412
ADIPOQ	LOC102346019	ENSLACP00000000452	ENSLACP00000019134	Adiponectin, C1Q and collagen domain containing.	C1q domain-containing protein.	0.904
ADIPOQ	SIRT1	ENSLACP00000000452	ENSLACP00000009079	Adiponectin, C1Q and collagen domain containing.	Sirtuin 1.	0.648
ALPK1	IRAK1	ENSLACP00000005110	ENSLACP00000014884	Alpha kinase 1.	Interleukin 1 receptor associated kinase 1.	0.472
ALPK1	LOC102348796	ENSLACP00000005110	ENSLACP00000023619	Alpha kinase 1.	Uncharacterized protein.	0.505
ALPK1	RIPK2	ENSLACP00000005110	ENSLACP00000004499	Alpha kinase 1.	Receptor interacting serine/threonine kinase 2.	0.599
ALPK1	TIFA	ENSLACP00000005110	ENSLACP00000008014	Alpha kinase 1.	TRAF interacting protein with forkhead associated domain.	0.873
ALPK1	TRAF6	ENSLACP00000005110	ENSLACP00000003556	Alpha kinase 1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.740
ANKRD17	H3B6K7_LATCH	ENSLACP00000017180	ENSLACP00000017528	Ankyrin repeat domain 17.	IKKbetaNEMObind domain-containing protein.	0.448
CARD11	FADD	ENSLACP00000004229	ENSLACP00000009943	Caspase recruitment domain family member 11.	Fas associated via death domain.	0.463
CARD11	H3B6K7_LATCH	ENSLACP00000004229	ENSLACP00000017528	Caspase recruitment domain family member 11.	IKKbetaNEMObind domain-containing protein.	0.761
CARD11	LOC102348796	ENSLACP00000004229	ENSLACP00000023619	Caspase recruitment domain family member 11.	Uncharacterized protein.	0.521
CARD11	MAP3K7	ENSLACP00000004229	ENSLACP00000011169	Caspase recruitment domain family member 11.	Mitogen-activated protein kinase kinase kinase 7.	0.805
CARD11	RHOH	ENSLACP00000004229	ENSLACP00000012746	Caspase recruitment domain family member 11.	Ras homolog family member H.	0.512
CARD11	RIPK2	ENSLACP00000004229	ENSLACP00000004499	Caspase recruitment domain family member 11.	Receptor interacting serine/threonine kinase 2.	0.521