(86 nodes) Dendritic spine network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (876 aa)
	LOC102359008	Uncharacterized protein. (1519 aa)
	LOC102354725	Glutamate receptor, ionotropic, AMPA 3a. (823 aa)
	PTPRO	Protein tyrosine phosphatase receptor type O. (1222 aa)
	LOC102367488	Uncharacterized protein. (178 aa)
	NGFR	Nerve growth factor receptor. (197 aa)
	SHISA7	Shisa family member 7. (469 aa)
	APP	Amyloid beta precursor protein. (652 aa)
	DRD5	Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (460 aa)
	P2RX6	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (419 aa)
	EEF2K	Eukaryotic elongation factor 2 kinase. (512 aa)
	LZTS1	Leucine zipper tumor suppressor 1. (493 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1088 aa)
	NTRK2	Tyrosine-protein kinase receptor. (819 aa)
	SHISA9	Uncharacterized protein. (172 aa)
	H3A1D7_LATCH	Uncharacterized protein. (157 aa)
	PPP1R9A	Protein phosphatase 1 regulatory subunit 9A. (1320 aa)
	SHANK1	SH3 and multiple ankyrin repeat domains 1. (1849 aa)
	ITPKA	Kinase; Belongs to the inositol phosphokinase (IPK) family. (308 aa)
	H3A3D9_LATCH	Uncharacterized protein. (748 aa)
	SYT11	Synaptotagmin 11. (429 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains 3. (1187 aa)
	P2RX3	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
	SHANK2	SH3 and multiple ankyrin repeat domains 2. (1161 aa)
	FMR1	Fragile X mental retardation 1. (627 aa)
	GPM6A	Glycoprotein M6A. (298 aa)
	TANC2	Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2. (1916 aa)
	LOC102345690	Zgc:175088. (247 aa)
	PALM	Paralemmin. (392 aa)
	PALMD	Palmdelphin. (561 aa)
	CTTNBP2	Cortactin binding protein 2. (1594 aa)
	H3ABC7_LATCH	Rho GTPase activating protein 33. (979 aa)
	FXR2	FMR1 autosomal homolog 2. (599 aa)
	NRGN	Neurogranin. (75 aa)
	PDLIM4	PDZ and LIM domain 4. (233 aa)
	LOC102363797	Uncharacterized protein. (603 aa)
	ABR	ABR activator of RhoGEF and GTPase. (583 aa)
	ATP6AP2	ATPase H+ transporting accessory protein 2. (367 aa)
	GRIA4	Glutamate ionotropic receptor AMPA type subunit 4. (903 aa)
	PRRT2	Uncharacterized protein. (97 aa)
	H3AL67_LATCH	Uncharacterized protein. (121 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (614 aa)
	CRIPT	CXXC repeat containing interactor of PDZ3 domain. (101 aa)
	GRM3	Glutamate metabotropic receptor 3. (880 aa)
	KCND1	Potassium voltage-gated channel, Shal-related subfamily, member 1; Belongs to the potassium channel family. (636 aa)
	ALS2	Alsin Rho guanine nucleotide exchange factor ALS2. (1678 aa)
	SYNDIG1	Synapse differentiation inducing 1. (208 aa)
	ABHD17C	Abhydrolase domain containing 17C. (295 aa)
	LOC102365688	Protein phosphatase 1 regulatory subunit 9A-like B. (908 aa)
	PTK2	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (673 aa)
	ARHGAP42	Rho GTPase activating protein 42. (783 aa)
	FXR1	FMR1 autosomal homolog 1. (679 aa)
	DTNBP1	Dystrobrevin binding protein 1. (355 aa)
	ABHD17B	Abhydrolase domain containing 17B. (288 aa)
	HOMER1	Homer scaffold protein 1. (367 aa)
	KCND2-2	Uncharacterized protein; Belongs to the potassium channel family. (260 aa)
	MYL7	Myosin light chain 7. (182 aa)
	FARP1	FERM, ARH/RhoGEF and pleckstrin domain protein 1. (1031 aa)
	ZNF804A	Zinc finger protein 804A. (1127 aa)
	ABHD17A	Abhydrolase domain containing 17A. (312 aa)
	APBA3	Amyloid beta precursor protein binding family A member 3. (462 aa)
	OPHN1	Oligophrenin 1. (745 aa)
	BAIAP2	BAI1 associated protein 2. (434 aa)
	LOC102357437	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (459 aa)
	KCND2	Potassium voltage-gated channel subfamily D member 2; Belongs to the potassium channel family. (371 aa)
	ARFGEF2	ADP ribosylation factor guanine nucleotide exchange factor 2. (1803 aa)
	NEURL1	Neuralized E3 ubiquitin protein ligase 1. (568 aa)
	CYFIP1	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1259 aa)
	CDC42	Cell division cycle 42. (156 aa)
	DAGLA	Uncharacterized protein. (147 aa)
	BCR	Uncharacterized protein. (1277 aa)
	H3BAT5_LATCH	Uncharacterized protein. (900 aa)
	DOCK10	Dedicator of cytokinesis 10; Belongs to the DOCK family. (2199 aa)
	DRD1	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (453 aa)
	LOC102347510	Dopamine receptor D6b; Belongs to the G-protein coupled receptor 1 family. (452 aa)
	USP8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1102 aa)
	KCND3	BTB domain-containing protein; Belongs to the potassium channel family. (320 aa)
	H3BGI5_LATCH	Uncharacterized protein; Belongs to the potassium channel family. (271 aa)
	GRIA1	Glutamate ionotropic receptor AMPA type subunit 1. (835 aa)
	APBA2	Amyloid beta precursor protein binding family A member 2. (757 aa)
	PPP1R9B	Protein phosphatase 1 regulatory subunit 9B. (857 aa)
	P2RX4	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (391 aa)
	APBA1	Amyloid beta precursor protein binding family A member 1. (812 aa)
	LZTS3	Leucine zipper tumor suppressor family member 3. (663 aa)
	USP50	Ubiquitin specific peptidase 50; Belongs to the peptidase C19 family. (358 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABR	CDC42	ENSLACP00000009056	ENSLACP00000018010	ABR activator of RhoGEF and GTPase.	Cell division cycle 42.	0.509
APBA1	APP	ENSLACP00000023158	ENSLACP00000001643	Amyloid beta precursor protein binding family A member 1.	Amyloid beta precursor protein.	0.955
APBA2	APP	ENSLACP00000021087	ENSLACP00000001643	Amyloid beta precursor protein binding family A member 2.	Amyloid beta precursor protein.	0.964
APBA3	APP	ENSLACP00000015831	ENSLACP00000001643	Amyloid beta precursor protein binding family A member 3.	Amyloid beta precursor protein.	0.750
APP	APBA1	ENSLACP00000001643	ENSLACP00000023158	Amyloid beta precursor protein.	Amyloid beta precursor protein binding family A member 1.	0.955
APP	APBA2	ENSLACP00000001643	ENSLACP00000021087	Amyloid beta precursor protein.	Amyloid beta precursor protein binding family A member 2.	0.964
APP	APBA3	ENSLACP00000001643	ENSLACP00000015831	Amyloid beta precursor protein.	Amyloid beta precursor protein binding family A member 3.	0.750
APP	FMR1	ENSLACP00000001643	ENSLACP00000006036	Amyloid beta precursor protein.	Fragile X mental retardation 1.	0.469
APP	GRIN2A	ENSLACP00000001643	ENSLACP00000002756	Amyloid beta precursor protein.	Glutamate ionotropic receptor NMDA type subunit 2A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.	0.457
APP	SYT11	ENSLACP00000001643	ENSLACP00000004647	Amyloid beta precursor protein.	Synaptotagmin 11.	0.518
ARHGAP42	CDC42	ENSLACP00000012770	ENSLACP00000018010	Rho GTPase activating protein 42.	Cell division cycle 42.	0.528
BAIAP2	CDC42	ENSLACP00000017063	ENSLACP00000018010	BAI1 associated protein 2.	Cell division cycle 42.	0.977
BAIAP2	CYFIP1	ENSLACP00000017063	ENSLACP00000017989	BAI1 associated protein 2.	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	0.818
BAIAP2	LOC102363797	ENSLACP00000017063	ENSLACP00000008575	BAI1 associated protein 2.	Uncharacterized protein.	0.401
BAIAP2	PTK2	ENSLACP00000017063	ENSLACP00000012721	BAI1 associated protein 2.	Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.528
BAIAP2	PTK2B	ENSLACP00000017063	ENSLACP00000000176	BAI1 associated protein 2.	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.528
BAIAP2	SHANK1	ENSLACP00000017063	ENSLACP00000003891	BAI1 associated protein 2.	SH3 and multiple ankyrin repeat domains 1.	0.401
BAIAP2	SHANK3	ENSLACP00000017063	ENSLACP00000004784	BAI1 associated protein 2.	SH3 and multiple ankyrin repeat domains 3.	0.563
BCR	CDC42	ENSLACP00000018368	ENSLACP00000018010	Uncharacterized protein.	Cell division cycle 42.	0.509
CDC42	ABR	ENSLACP00000018010	ENSLACP00000009056	Cell division cycle 42.	ABR activator of RhoGEF and GTPase.	0.509