(13 nodes) Response to leucine network (Latimeria chalumnae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SESN3	Sestrin 3. (323 aa)
	LARS1	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1178 aa)
	LOC102356692	Si:zfos-80g12.1. (503 aa)
	UBR1	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1724 aa)
	LOC102351332	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1067 aa)
	H3AZY7_LATCH	Kelch-like family member 22. (628 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
	H3B8U3_LATCH	Serine/threonine-protein kinase TOR. (1418 aa)
	MTOR	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (1009 aa)
	UBR2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1767 aa)
	SESN2	Sestrin 2. (463 aa)
	SESN1	Sestrin 1. (463 aa)
	RPTOR	Regulatory associated protein of MTOR complex 1. (1334 aa)

Your Current Organism:

Latimeria chalumnae

NCBI taxonomy Id: 7897
Other names: L. chalumnae, coelacanth

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
H3B8U3_LATCH	MTOR	ENSLACP00000018314	ENSLACP00000018843	Serine/threonine-protein kinase TOR.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.944
H3B8U3_LATCH	RPTOR	ENSLACP00000018314	ENSLACP00000023161	Serine/threonine-protein kinase TOR.	Regulatory associated protein of MTOR complex 1.	0.979
LARS1	RPTOR	ENSLACP00000010578	ENSLACP00000023161	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	Regulatory associated protein of MTOR complex 1.	0.508
LOC102356692	RPTOR	ENSLACP00000010472	ENSLACP00000023161	Si:zfos-80g12.1.	Regulatory associated protein of MTOR complex 1.	0.469
LOC102356692	SESN2	ENSLACP00000010472	ENSLACP00000019626	Si:zfos-80g12.1.	Sestrin 2.	0.905
MTOR	H3B8U3_LATCH	ENSLACP00000018843	ENSLACP00000018314	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase TOR.	0.944
MTOR	PIK3CA	ENSLACP00000018843	ENSLACP00000017606	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.926
MTOR	RPTOR	ENSLACP00000018843	ENSLACP00000023161	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Regulatory associated protein of MTOR complex 1.	0.997
MTOR	SESN2	ENSLACP00000018843	ENSLACP00000019626	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	Sestrin 2.	0.507
PIK3CA	MTOR	ENSLACP00000017606	ENSLACP00000018843	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.926
RPTOR	H3B8U3_LATCH	ENSLACP00000023161	ENSLACP00000018314	Regulatory associated protein of MTOR complex 1.	Serine/threonine-protein kinase TOR.	0.979
RPTOR	LARS1	ENSLACP00000023161	ENSLACP00000010578	Regulatory associated protein of MTOR complex 1.	Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.	0.508
RPTOR	LOC102356692	ENSLACP00000023161	ENSLACP00000010472	Regulatory associated protein of MTOR complex 1.	Si:zfos-80g12.1.	0.469
RPTOR	MTOR	ENSLACP00000023161	ENSLACP00000018843	Regulatory associated protein of MTOR complex 1.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.997
RPTOR	SESN1	ENSLACP00000023161	ENSLACP00000019680	Regulatory associated protein of MTOR complex 1.	Sestrin 1.	0.493
RPTOR	SESN2	ENSLACP00000023161	ENSLACP00000019626	Regulatory associated protein of MTOR complex 1.	Sestrin 2.	0.493
RPTOR	SESN3	ENSLACP00000023161	ENSLACP00000012960	Regulatory associated protein of MTOR complex 1.	Sestrin 3.	0.476
SESN1	RPTOR	ENSLACP00000019680	ENSLACP00000023161	Sestrin 1.	Regulatory associated protein of MTOR complex 1.	0.493
SESN2	LOC102356692	ENSLACP00000019626	ENSLACP00000010472	Sestrin 2.	Si:zfos-80g12.1.	0.905
SESN2	MTOR	ENSLACP00000019626	ENSLACP00000018843	Sestrin 2.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.507